IndraLab
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"We determined that EGF activates phosphorylation of Akt, mTOR, p70S6 kinase, ribosomal protein S6, eIF4E and 4E-BP1 in a PI-3-kinase dependent manner, and PI-3-kinase activation may prevent lactogenic differentiation in HC11 mammary epithelial cells by regulating the synthesis of proteins."
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"Biochemical analyses confirmed that CC214-1 successfully inhibited mTORC1 dependent 4E-BP1 and S6 phosphorylation in EGFRvIII-expressing GBM cells ( xref and xref , xref ), as well as blocked EGF-induced 4E-BP1 and S6 phosphorylation in GBM cells overexpressing wild type EGFR ( xref )."