The INDRA Database: Results

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading
TSC1 inhibits RPS6KB1. 7 / 7
| 2 5
reach
"In cancer, there is an increase in the activity of PI3K-AKT axis, and TSC1 and TSC2 is inhibited by AKT, allowing mTORC1 activation and subsequently activation of P70S6K1 and EIF4e."
27156070
reach
"Moreover, in mammalian cells in culture, co-overexpression of TSC1 and TSC2 prevents amino acid dependent activation of S6K1 [XREF_BIBR]."
15507151
sparser
"It will be of great interest to determine the molecular nature of S6K1 inhibition by the tuberin-hamartin complex in the absence of mitogenic stimuli."
12150915
reach
"Hamartin with alanine mutations in the three cyclin dependent kinase 1 phosphorylation sites increased the inhibition of p70S6 kinase by the hamartin and tuberin complex."
14551205
sparser
"Hamartin with alanine mutations in the three cyclin-dependent kinase 1 phosphorylation sites increased the inhibition of p70S6 kinase by the hamartin-tuberin complex."
14551205
reach
"Over-expression of TSC1 and TSC2 also markedly inhibited S6K1, positioning TSC1 and TSC2 upstream of S6K1."
29547541
reach
"Incubation of RMCs with 1,25 (OH) 2 D 3 for 48 h increased VDR expression (p < 0.05), restored the expression of TSC1 and TSC2 and 4E-BP1, and blocked the aberrant upregulation of Rheb, mTOR and p70S6K."
29416624
Catalytically active TSC1 bound to TSC2 inhibits RPS6KB1. 1 / 1
1 |
bel
"Furthermore, in insulin- or serum-stimulated cells, activation of p70S6K is inhibited by expression of the Tsc1-Tsc2 complex [54,55]. This finding demonstrates that the introduction of a genetic inhibitor of mTOR, downstream of Akt1, inhibits the activation of p70S6K, adding genetic evidence for an Akt1-mTOR-p70S6K pathway."
12928036