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Catalytically active TSC1 bound to TSC2 inhibits RPS6KB1. 1 / 1

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"Furthermore, in insulin- or serum-stimulated cells, activation of p70S6K is inhibited by expression of the Tsc1-Tsc2 complex [54,55]. This finding demonstrates that the introduction of a genetic inhibitor of mTOR, downstream of Akt1, inhibits the activation of p70S6K, adding genetic evidence for an Akt1-mTOR-p70S6K pathway."

12928036

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IndraLab

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Catalytically active TSC1 bound to TSC2 inhibits RPS6KB1. 1 / 1

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