"This loss of TbetaRII prevents downstream activation of Smad2 and target genes as p15, an important regulator of cell cycle progression."
"Linc00462 promotes and miR-665 inhibits the malignant phenotype of PC by regulating the TGFBR1 and TGFBR2 induced SMAD2 and SMAD3 signaling pathway."
"The EOB phenotype was observed in mice lacking the type I BMP receptor genes, Acvr1 and Bmpr1a, the R-Smad genes, Smad 1 and Smad5, and the Co-Smad gene, Smad 4, but not in mice lacking the type II TGFbeta receptor gene Tgfbr2 and the activin and TGFbeta activated R-Smad genes, Smad2 and Smad3."
"20 During TGF-beta pathway mediated hypertrophic scar formation, there is an up-regulation of SMAD-2 and SMAD-3, as well as increased expression of TGF-beta1, TbetaRI and TbetaRII, which lead to positive feedback loop."
"Of the five R-Smads in mammals, the TGFBR2–ALK5 complex activates SMAD2 and SMAD3, whereas the TGFBR2–ALK1 complex activates SMAD1, SMAD5 and SMAD8 xref ."
"Silencing TbetaRII not only reduced ATF2 activation but also that of Smad2, indicating the critical importance of TbetaRII in mediating TGFbeta signaling."
"The reduced P-Smad2 and Smad3 and Foxp3 were reversed by TbetaRII agonist."