A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

TGFBR2 activates SMAD2. 7 / 7
| 1 6
reach
"This loss of TbetaRII prevents downstream activation of Smad2 and target genes as p15, an important regulator of cell cycle progression."
reach
"Linc00462 promotes and miR-665 inhibits the malignant phenotype of PC by regulating the TGFBR1 and TGFBR2 induced SMAD2 and SMAD3 signaling pathway."
reach
"The EOB phenotype was observed in mice lacking the type I BMP receptor genes, Acvr1 and Bmpr1a, the R-Smad genes, Smad 1 and Smad5, and the Co-Smad gene, Smad 4, but not in mice lacking the type II TGFbeta receptor gene Tgfbr2 and the activin and TGFbeta activated R-Smad genes, Smad2 and Smad3."
reach
"20 During TGF-beta pathway mediated hypertrophic scar formation, there is an up-regulation of SMAD-2 and SMAD-3, as well as increased expression of TGF-beta1, TbetaRI and TbetaRII, which lead to positive feedback loop."
sparser
"Of the five R-Smads in mammals, the TGFBR2–ALK5 complex activates SMAD2 and SMAD3, whereas the TGFBR2–ALK1 complex activates SMAD1, SMAD5 and SMAD8 xref ."
reach
"Silencing TbetaRII not only reduced ATF2 activation but also that of Smad2, indicating the critical importance of TbetaRII in mediating TGFbeta signaling."
reach
"The reduced P-Smad2 and Smad3 and Foxp3 were reversed by TbetaRII agonist."
Kinase-active TGFBR2 activates SMAD2. 5 / 5
3 2 |
bel
"Modified assertion"
bel
"TGF? binds to TGF? receptor II on T cells, which leads to the recruitment of TGF? receptor I to the complex and activation of cytoplasmic transcription factors SMAD2 and SMAD3."
bel
"TGF? binds to TGF? receptor II on T cells, which leads to the recruitment of TGF? receptor I to the complex and activation of cytoplasmic transcription factors SMAD2 and SMAD3. "
bel
"TGFbeta markedly and specifically decreases both mRNA and protein levels of a HIF-1alpha-associated prolyl hydroxylase (PHD), PHD2, through the Smad signaling pathway."
bel
"Modified assertion"
TGFBR2 bound to ALK5 receptor activates SMAD2. 1 / 1
| 1
reach
"TGF-beta signalling is mediated by the TbetaRII and ALK5 receptor complex activating the Smad2 and Smad3 pathway."
TGFBR2 bound to TGFBR1 activates SMAD2. 1 / 1
| 1
reach
"Of the five R-Smads in mammals, the TGFBR2 and ALK5 complex activates SMAD2 and SMAD3, whereas the TGFBR2 and ALK1 complex activates SMAD1, SMAD5 and SMAD8 XREF_BIBR."