IndraLab

Statements

TGFBR2 activates SMAD2. 10 / 10
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"Linc00462 promotes and miR-665 inhibits the malignant phenotype of PC by regulating the TGFBR1 and TGFBR2 induced SMAD2 and SMAD3 signaling pathway."
29899418
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"20 During TGF-beta pathway mediated hypertrophic scar formation, there is an up-regulation of SMAD-2 and SMAD-3, as well as increased expression of TGF-beta1, TbetaRI and TbetaRII, which lead to positive feedback loop."
28303029
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"Of the five R-Smads in mammals, the TGFBR2–ALK5 complex activates SMAD2 and SMAD3, whereas the TGFBR2–ALK1 complex activates SMAD1, SMAD5 and SMAD8 xref ."
21799915
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"Tbeta RII activates Tbeta RI, which, in turn, propagates the TGF-beta signal by phosphorylating the Smads, in particular Smad2 and Smad3 (Massague & Chen, 2000)."
17766170
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"The binding of TGF-β to its receptors TGFR1 and TGFR2 activates Smad2 and Smad3 through direct phosphorylation."
31817513
sparser
"When released from LAP (latency-associated peptide) and LTBP (latent TGF-β-binding protein), active TGF-β1 binds with its type II receptor that activates type I receptor and downstream effectors, Smad2 and Smad3, to regulate genes associated with renal fibrosis xref ."
31754396
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"This loss of TbetaRII prevents downstream activation of Smad2 and target genes as p15, an important regulator of cell cycle progression."
25776923
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"Silencing TbetaRII not only reduced ATF2 activation but also that of Smad2, indicating the critical importance of TbetaRII in mediating TGFbeta signaling."
24674138
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"The EOB phenotype was observed in mice lacking the type I BMP receptor genes, Acvr1 and Bmpr1a, the R-Smad genes, Smad 1 and Smad5, and the Co-Smad gene, Smad 4, but not in mice lacking the type II TGFbeta receptor gene Tgfbr2 and the activin and TGFbeta activated R-Smad genes, Smad2 and Smad3."
24498290
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"The reduced P-Smad2 and Smad3 and Foxp3 were reversed by TbetaRII agonist."
28300338
Kinase-active TGFBR2 activates SMAD2. 5 / 5
3 2 |
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"TGFbeta markedly and specifically decreases both mRNA and protein levels of a HIF-1alpha-associated prolyl hydroxylase (PHD), PHD2, through the Smad signaling pathway."
16815840
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"TGF? binds to TGF? receptor II on T cells, which leads to the recruitment of TGF? receptor I to the complex and activation of cytoplasmic transcription factors SMAD2 and SMAD3. "
20656683
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"Modified assertion"
12421823
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"Modified assertion"
12421823
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"TGF? binds to TGF? receptor II on T cells, which leads to the recruitment of TGF? receptor I to the complex and activation of cytoplasmic transcription factors SMAD2 and SMAD3."
20656683
TGFBR2 bound to TGFBR1 activates SMAD2. 2 / 2
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"The TbetaRII and ALK-5 complex activates Smad2 and Smad3, whereas the TbetaRII and ALK-1 complex activates Smad1, Smad5 and Smad8 [51]."
23707512
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"Of the five R-Smads in mammals, the TGFBR2 and ALK5 complex activates SMAD2 and SMAD3, whereas the TGFBR2 and ALK1 complex activates SMAD1, SMAD5 and SMAD8 XREF_BIBR."
21799915
TGFBR2 bound to ALK5 receptor activates SMAD2. 1 / 1
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"TGF-beta signalling is mediated by the TbetaRII and ALK5 receptor complex activating the Smad2 and Smad3 pathway."
16594992