IndraLab

Statements

TGFBR2 activates SMAD2. 11 / 11
| 7 4
reach
"Linc00462 promotes and miR-665 inhibits the malignant phenotype of PC by regulating the TGFBR1 and TGFBR2 induced SMAD2 and SMAD3 signaling pathway."
29899418
reach
"The reduced P-Smad2 and Smad3 and Foxp3 were reversed by TbetaRII agonist."
28300338
reach
"Tbeta RII activates Tbeta RI, which, in turn, propagates the TGF-beta signal by phosphorylating the Smads, in particular Smad2 and Smad3 (Massague & Chen, 2000)."
17766170
sparser
"Activin A (hereafter Activin-A) is a multifunctional secreted protein of the transforming growth factor (TGF)-β family that can activate SMAD2 and SMAD3 transcription factors and SMAD-independent signal transduction pathways by assembling heterooligomeric complexes of activin receptor (ActR)-IB with ActR-IIA or -IIB xref ."
40064965
reach
"This loss of TbetaRII prevents downstream activation of Smad2 and target genes as p15, an important regulator of cell cycle progression."
25776923
sparser
"The binding of TGF-β to its receptors TGFR1 and TGFR2 activates Smad2 and Smad3 through direct phosphorylation."
31817513
reach
"20 During TGF-beta pathway mediated hypertrophic scar formation, there is an up-regulation of SMAD-2 and SMAD-3, as well as increased expression of TGF-beta1, TbetaRI and TbetaRII, which lead to positive feedback loop."
28303029
sparser
"When released from LAP (latency-associated peptide) and LTBP (latent TGF-β-binding protein), active TGF-β1 binds with its type II receptor that activates type I receptor and downstream effectors, Smad2 and Smad3, to regulate genes associated with renal fibrosis xref ."
31754396
sparser
"Of the five R-Smads in mammals, the TGFBR2–ALK5 complex activates SMAD2 and SMAD3, whereas the TGFBR2–ALK1 complex activates SMAD1, SMAD5 and SMAD8 xref ."
21799915
reach
"Silencing TbetaRII not only reduced ATF2 activation but also that of Smad2, indicating the critical importance of TbetaRII in mediating TGFbeta signaling."
24674138
reach
"The EOB phenotype was observed in mice lacking the type I BMP receptor genes, Acvr1 and Bmpr1a, the R-Smad genes, Smad 1 and Smad5, and the Co-Smad gene, Smad 4, but not in mice lacking the type II TGFbeta receptor gene Tgfbr2 and the activin and TGFbeta activated R-Smad genes, Smad2 and Smad3."
24498290