IndraLab

Statements

TGFBR2 activates SMAD2. 10 / 10
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"Linc00462 promotes and miR-665 inhibits the malignant phenotype of PC by regulating the TGFBR1 and TGFBR2 induced SMAD2 and SMAD3 signaling pathway."
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"20 During TGF-beta pathway mediated hypertrophic scar formation, there is an up-regulation of SMAD-2 and SMAD-3, as well as increased expression of TGF-beta1, TbetaRI and TbetaRII, which lead to positive feedback loop."
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"Of the five R-Smads in mammals, the TGFBR2–ALK5 complex activates SMAD2 and SMAD3, whereas the TGFBR2–ALK1 complex activates SMAD1, SMAD5 and SMAD8 xref ."
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"Tbeta RII activates Tbeta RI, which, in turn, propagates the TGF-beta signal by phosphorylating the Smads, in particular Smad2 and Smad3 (Massague & Chen, 2000)."
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"The binding of TGF-β to its receptors TGFR1 and TGFR2 activates Smad2 and Smad3 through direct phosphorylation."
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"When released from LAP (latency-associated peptide) and LTBP (latent TGF-β-binding protein), active TGF-β1 binds with its type II receptor that activates type I receptor and downstream effectors, Smad2 and Smad3, to regulate genes associated with renal fibrosis xref ."
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"This loss of TbetaRII prevents downstream activation of Smad2 and target genes as p15, an important regulator of cell cycle progression."
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"Silencing TbetaRII not only reduced ATF2 activation but also that of Smad2, indicating the critical importance of TbetaRII in mediating TGFbeta signaling."
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"The EOB phenotype was observed in mice lacking the type I BMP receptor genes, Acvr1 and Bmpr1a, the R-Smad genes, Smad 1 and Smad5, and the Co-Smad gene, Smad 4, but not in mice lacking the type II TGFbeta receptor gene Tgfbr2 and the activin and TGFbeta activated R-Smad genes, Smad2 and Smad3."
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"The reduced P-Smad2 and Smad3 and Foxp3 were reversed by TbetaRII agonist."
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