IndraLab

Statements

TGFB1 increases the amount of FOXP3. 10 / 70
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"Finally, although the enhancement of FOXP3 expression by transforming growth factor-beta1 (TGF-beta1) in activated human CD4 + CD25 - T h cells generates so called induced T reg (iT reg) cells, this phenotype is rapidly lost [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
20137067
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"As shown in XREF_SUPPLEMENTARY, addition of TGFbeta-1 or wild-type Treg cells induced the expression of Foxp3 in both wild-type and furin deficient CD4 + naive T cells."
18701887
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"TGF-beta1 has been shown to induce FOXP3 expression in naive T cells and their conversion into regulatory T cells XREF_BIBR."
26437631
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"As the induction of Foxp3 by Tci-L4-ES is thought to be due to the presence of parasite homologues of transforming growth factor-beta (TGF-beta1), a cytokine which preferentially induces Foxp3 expression in naive rather than non naive CD4 + T cells [XREF_BIBR, XREF_BIBR], we also determined whether Tc-L4-ES was able to induce Foxp3 expression in purified naive ovine CD4 + T cells."
23964850
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"Tumor derived TGF-beta1 has been showed to induce the expression of Foxp3, which is a firm link between TGF-beta1 levels and Tregs [XREF_BIBR, XREF_BIBR]."
27036297
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"Real-time PCR showed that Foxp3 expression was not up-regulated by M-CSF alone, M-CSF plus IL-4, or M-CSF plus TGFbeta1 treatments in peritoneal macrophages."
23046996
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"TGF-beta1 also induces FOXP3 expression, while IL-6 inhibits its expression [XREF_BIBR]."
29254235
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"In the absence of IL-6, TGF-beta1 induces the expression of Foxp3 in naive CD4 + T cells in vitro XREF_BIBR, XREF_BIBR - XREF_BIBR and in vivo XREF_BIBR, XREF_BIBR."
22087328
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"Consistently, TGF-beta1 can induce the co-expression of FoxP3 and RORgammat, the lineage defining transcription factors of Treg and Th17 cells, respectively XREF_BIBR."
23976880
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"Firstly, reactive oxygen species (ROS) produced by TCR activated CD4 + CD25 - T cells has a role in producing active TGFbeta1, and endogenous TGFbeta1 production in turn induces Foxp3 expression in human CD4 + CD25 - T cells."
30842769
Modified TGFB1 increases the amount of FOXP3. 5 / 5
| 5
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"This unique coexpression of high levels of TGF-beta1, RALDH1, and RALDH2 in lung tissue MOs directly correlated with the intrinsic ability of these cells to induce Foxp3 expression (XREF_FIG)."
23547101
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"They also suggest that high levels of TGF-beta1 do not accelerate the early kinetics of FOXP3 expression, and the enhanced T reg cell differentiation seen in T reg hi conditions may reflect either stabilization of the FOXP3 + state and/or higher TGF-beta1 levels available at later timepoints to continue driving T reg cell differentiation."
25998054
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"Further analysis indicated that high-dose FDPGLM significantly increased the serum levels of TGF-beta1, which in turn promoted wound healing, upregulated the expression of the Foxp3 gene, and enhanced CD4 + CD25 + Foxp3 + Tregs differentiation, thereby facilitating immune regulation, inhibition of cellular immunity, and release of inflammatory cytokines."
29191190
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"Although TGF-beta1 is necessary for differentiation of pathogenic Th17 cells, recent studies indicate that heightened levels of TGF-beta1 induces increased levels of Foxp3, which reduces Th17 cell differentiation."
21311970
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"By using an autocrine mechanism T-cell specific transgenic TGFbeta1 overexpression leads to an increased frequency of CD4+ CD25+ cells and an overexpression of the Treg specific transcription factor Foxp3 in the thymus XREF_BIBR."
24339930
TGFB1 bound to TGF-beta1 receptors increases the amount of FOXP3. 1 / 1
| 1
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"These autocrine and/or paracrine TGF-beta1 could bind TGF-beta1 receptors on Vdelta1 T cells and induce sustained Foxp3 expression."
23532670