IndraLab

Statements

STK11 phosphorylates TP53. 10 / 13
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"In addition, LKB1 knockdown with LKB1 siRNA dramatically decreased AMPK, P38MAPK, and p53 phosphorylation in lovastatin-treated MCF-7 cells.These results confirmed that lovastatin may activate the LKB1-AMPK-p38MAPK-p53 signaling cascade and lead to reduced survival and increased death of MCF-7 and MDA-MB-231 cell lines [47] ."
33939118
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"The activated LKB1 and AMPK pathway in AMC-HN-3 cells caused G1 arrest by phosphorylating p53 and suppressing mTOR signaling."
23280187
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"The tumor suppressor LKB1, a serine/threonine kinase which associates with and phosphorylates p53 at Ser 15 and -392, promotes cell cycle arrest in G 1 through p21 [XREF_BIBR]."
20100570
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"The phosphorylation of p53 induced by LKB1 required the kinase activity of NUAK1 and phosphorylation of NUAK1 at Thr211 by LKB1 was essential for its kinase activity, which leads to the conclusion that LKB1 activates NUAK1 and regulates phosphorylation of p53 through the NUAK1 kinase, at least partially."
21317932
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"In response to specific stimuli, LKB1 phosphorylates the p53 transcription factor at specific sites, which increases the affinity of p53 for its target promoters, including that of the p21 gene, thereby increasing target gene expression."
26459766
rlimsp
"The phosphorylation of p53 induced by LKB1 required the kinase activity of NUAK1 and phosphorylation of NUAK1 at Thr211 by LKB1 was essential for its kinase activity, which leads to the conclusion that LKB1 activates NUAK1 and regulates phosphorylation of p53 through the NUAK1 kinase, at least partially."
21317932
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"However, LKB1 can also play an anti-apoptotic role in tumor cells with constitutively active Akt and can mediate phosphorylation of p53 by decreasing its nuclear import, suggesting that LKB1 may be potentially oncogenic."
20815019
sparser
"Both LKB 1 and AMPK may phosphorylate p53 under some conditions."
30040046
sparser
"In response to specific stimuli, LKB1 phosphorylates the p53 transcription factor at specific sites ( xref , xref ), which increases the affinity of p53 for its target promoters, including that of the p21 gene, thereby increasing target gene expression ( xref , xref )."
26459766
rlimsp
"Here we demonstrate that all six LKB1/STK11 variants analysed are completely inactive in vitro as they were unable to autophosphorylate at Thr336, the major LKB1/STK11 autophosphorylation site, and to phosphorylate the p53 tumour suppressor protein."
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STK11 phosphorylates TP53 on S15. 7 / 8
1 1 | 4 1
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"Furthermore, LKB1, the upstream activator of AMPK, directly or indirectly phosphorylates p53 at Ser15 and Ser392, and activates the transcription of p21 following UV treatment (Zeng and Berger, 2006)."
34869377
reach
"The tumor suppressor LKB1, a serine/threonine kinase which associates with and phosphorylates p53 at Ser 15 and -392, promotes cell cycle arrest in G 1 through p21 [XREF_BIBR]."
20100570
sparser
"Furthermore, LKB1, the upstream activator of AMPK, directly or indirectly phosphorylates p53 at Ser15 and Ser392, and activates the transcription of p21 following UV treatment (Zeng and Berger, 2006)."
34869377
biopax:phosphositeplus
No evidence text available
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"Zeng et al reported that LKB1 physically associates with p53 in the nucleus and phosphorylates p53 at the amino acid residues Ser15 and Ser392."
26459766
signor
"We show that lkb1 physically associates with p53 in the nucleus and directly or indirectly phosphorylates p53 ser15 (previously shown to be phosphorylated by amp-dependent kinase) and p53 ser392"
17108107
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"We show that LKB1 physically associates with p53 in the nucleus and directly or indirectly phosphorylates p53 Ser15 (previously shown to be phosphorylated by AMP dependent kinase) and p53 Ser392."
17108107
STK11 phosphorylates TP53 on S392. 7 / 7
1 1 | 4 1
sparser
"Furthermore, LKB1, the upstream activator of AMPK, directly or indirectly phosphorylates p53 at Ser15 and Ser392, and activates the transcription of p21 following UV treatment (Zeng and Berger, 2006)."
34869377
signor
"We show that lkb1 physically associates with p53 in the nucleus and directly or indirectly phosphorylates p53 ser15 (previously shown to be phosphorylated by amp-dependent kinase) and p53 ser392"
17108107
reach
"LKB1 binds to and phosphorylates p53 at Ser389 reducing the efficiency in its nuclear import."
20815019
reach
"Furthermore, LKB1, the upstream activator of AMPK, directly or indirectly phosphorylates p53 at Ser15 and Ser392, and activates the transcription of p21 following UV treatment (Zeng and Berger, 2006)."
34869377
reach
"Zeng et al reported that LKB1 physically associates with p53 in the nucleus and phosphorylates p53 at the amino acid residues Ser15 and Ser392."
26459766
biopax:phosphositeplus
No evidence text available
reach
"We show that LKB1 physically associates with p53 in the nucleus and directly or indirectly phosphorylates p53 Ser15 (previously shown to be phosphorylated by AMP dependent kinase) and p53 Ser392."
17108107
Kinase-active STK11 leads to the phosphorylation of TP53 on S15. 1 / 1
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bel
"We show that LKB1 physically associates with p53 in the nucleus and directly or indirectly phosphorylates p53 Ser15 (previously shown to be phosphorylated by AMP-dependent kinase) and p53 Ser392."
17108107
Phosphorylated STK11 leads to the phosphorylation of TP53. 1 / 1
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"Besides, the phosphorylation of STK11 promoted cell death, cell growth arrest, and metastasis by directly phosphorylating P53 (Tiainen et al., 2002; Cheng et al., 2009; Karuman et al., 2001)."
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