IndraLab

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STK11 phosphorylates TP53. 18 / 19
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"The tumor suppressor LKB1, a serine/threonine kinase which associates with and phosphorylates p53 at Ser 15 and -392, promotes cell cycle arrest in G 1 through p21 [XREF_BIBR]."
20100570
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"The phosphorylation of p53 induced by LKB1 required the kinase activity of NUAK1 and phosphorylation of NUAK1 at Thr211 by LKB1 was essential for its kinase activity, which leads to the conclusion that LKB1 activates NUAK1 and regulates phosphorylation of p53 through the NUAK1 kinase, at least partially."
21317932
sparser
"Following treatment with varying concentrations of Iso, the liver kinase B1(LKB1) phosphorylates the p53 transcription factor at specific sites, enhancing its affinity for its target promoter, the p21 gene."
39334933
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"In addition, LKB1 knockdown with LKB1 siRNA dramatically decreased AMPK, P38MAPK, and p53 phosphorylation in lovastatin-treated MCF-7 cells."
33939118
rlimsp
"Here we demonstrate that all six LKB1/STK11 variants analysed are completely inactive in vitro as they were unable to autophosphorylate at Thr336, the major LKB1/STK11 autophosphorylation site, and to phosphorylate the p53 tumour suppressor protein."
12552571
rlimsp
"The phosphorylation of p53 induced by LKB1 required the kinase activity of NUAK1 and phosphorylation of NUAK1 at Thr211 by LKB1 was essential for its kinase activity, which leads to the conclusion that LKB1 activates NUAK1 and regulates phosphorylation of p53 through the NUAK1 kinase, at least partially."
21317932
sparser
"Also, AMPK with LKB1 acts as a kinase for p53 at the serine 15 phosphorylation site, which indicates that LKB1 phosphorylates p53 with AMPK or it can directly phosphorylate p53."
31002918
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"In response to specific stimuli, LKB1 phosphorylates the p53 transcription factor at specific sites, which increases the affinity of p53 for its target promoters, including that of the p21 gene, thereby increasing target gene expression."
26459766
sparser
"In response to specific stimuli, LKB1 phosphorylates the p53 transcription factor at specific sites ( xref , xref ), which increases the affinity of p53 for its target promoters, including that of the p21 gene, thereby increasing target gene expression ( xref , xref )."
26459766
sparser
"For example, LKB1 can directly phosphorylate and activate p53 through its downstream targets such as NUAK1, thereby promoting cell cycle G1/S phase arrest and acting as a tumor suppressor xref ."
40675970
sparser
"Studies have shown that LKB1 can directly bind to and phosphorylate p53 , enhancing the transcriptional activity of p21/WAF1 and so on xref ."
40675970
sparser
"Alternatively, LKB1 substrate kinase phosphorylation and activation of p53 could be needed for proper activation of Smad dependent transcription [96] ."
21192934
sparser
"Both LKB 1 and AMPK may phosphorylate p53 under some conditions."
30040046
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"However, LKB1 can also play an anti-apoptotic role in tumor cells with constitutively active Akt and can mediate phosphorylation of p53 by decreasing its nuclear import, suggesting that LKB1 may be potentially oncogenic."
20815019
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"Following treatment with varying concentrations of Iso, the liver kinase B1(LKB1) phosphorylates the p53 transcription factor at specific sites, enhancing its affinity for its target promoter, the p21 gene."
39334933
reach
"STK11 can directly interact with and phosphorylate P53, and to mediate P53-induced apoptosis [40]."
30092773
reach
"Also, AMPK with LKB1 acts as a kinase for p53 at the serine 15 phosphorylation site, which indicates that LKB1 phosphorylates p53 with AMPK or it can directly phosphorylate p53."
31002918
sparser
"They mapped the phosphorylation sites within p53 by making individual domains and substitution mutants and found that two major sites of phosphorylation in p53 by LKB1 were S15 and S392 in vitro and in vivo."
28920233