IndraLab

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STK11 phosphorylates TP53. 14 / 17
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"However, LKB1 can also play an anti-apoptotic role in tumor cells with constitutively active Akt and can mediate phosphorylation of p53 by decreasing its nuclear import, suggesting that LKB1 may be potentially oncogenic."
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"The phosphorylation of p53 induced by LKB1 required the kinase activity of NUAK1 and phosphorylation of NUAK1 at Thr211 by LKB1 was essential for its kinase activity, which leads to the conclusion that LKB1 activates NUAK1 and regulates phosphorylation of p53 through the NUAK1 kinase, at least partially."
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"Alternatively, LKB1 substrate kinase phosphorylation and activation of p53 could be needed for proper activation of Smad dependent transcription [96] ."
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"Following treatment with varying concentrations of Iso, the liver kinase B1(LKB1) phosphorylates the p53 transcription factor at specific sites, enhancing its affinity for its target promoter, the p21 gene."
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"Following treatment with varying concentrations of Iso, the liver kinase B1(LKB1) phosphorylates the p53 transcription factor at specific sites, enhancing its affinity for its target promoter, the p21 gene."
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"They mapped the phosphorylation sites within p53 by making individual domains and substitution mutants and found that two major sites of phosphorylation in p53 by LKB1 were S15 and S392 in vitro and in vivo."
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"STK11 can directly interact with and phosphorylate P53, and to mediate P53-induced apoptosis [40]."
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"Both LKB 1 and AMPK may phosphorylate p53 under some conditions."
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"In addition, LKB1 knockdown with LKB1 siRNA dramatically decreased AMPK, P38MAPK, and p53 phosphorylation in lovastatin-treated MCF-7 cells."
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"Also, AMPK with LKB1 acts as a kinase for p53 at the serine 15 phosphorylation site, which indicates that LKB1 phosphorylates p53 with AMPK or it can directly phosphorylate p53."
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"Also, AMPK with LKB1 acts as a kinase for p53 at the serine 15 phosphorylation site, which indicates that LKB1 phosphorylates p53 with AMPK or it can directly phosphorylate p53."
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"In response to specific stimuli, LKB1 phosphorylates the p53 transcription factor at specific sites, which increases the affinity of p53 for its target promoters, including that of the p21 gene, thereby increasing target gene expression."
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"In response to specific stimuli, LKB1 phosphorylates the p53 transcription factor at specific sites ( xref , xref ), which increases the affinity of p53 for its target promoters, including that of the p21 gene, thereby increasing target gene expression ( xref , xref )."
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"The tumor suppressor LKB1, a serine/threonine kinase which associates with and phosphorylates p53 at Ser 15 and -392, promotes cell cycle arrest in G 1 through p21 [XREF_BIBR]."
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