IndraLab

Statements

STAT3 increases the amount of HIF1A. 10 / 67
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"This occurs both within the tumor by autocrine and/or paracrine signaling and by tumor-extrinsic positive-feedback amplification of STAT3 transcription factor, which increases expression of pro angiogenic VEGF and HIF1alpha."
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"STAT3 can be activated via the JAK and STAT3 (pY705) pathway, which induces HIF-1alpha and VEGF expression."
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"In addition, inhibition of STAT3 alone is adequate to directly downregulate HIF-1alpha and cyclin D1 expression."
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No evidence text available
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"Similarly, inhibiting the PI3K/Akt and STAT3 pathways also decreased the expression HIF-1alpha and cell proliferation."
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"STAT3 has been shown to increase HIF-1alpha levels by extension of protein half-life but also induction of HIF-1alpha transcription in human and mouse melanoma cells [XREF_BIBR, XREF_BIBR]."
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"The constitutive activation of STAT3 induces HIF-1alpha expression, stimulates glycolysis, and decreases mitochondrial activity."
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"STAT3 modulates the stability and activity of HIF-1alpha, and activated STAT3 increases the HIF-1alpha protein level by increasing HIF-1alpha stability through blocking HIF-1alpha degradation and accelerating its de novo synthesis."
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No evidence text available
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"Recent studies show that STAT3 directly activates VEGF and HIF-1alpha transcription under hypoxic conditions, which results in the initiation of endothelial cell migration and angiogenesis [XREF_BIBR]."
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Phosphorylated STAT3 increases the amount of HIF1A. 5 / 5
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"Indeed, STAT3 phosphorylation increases expression of HIF1alpha by inhibiting HIF1alpha degradation in tumor cells [XREF_BIBR]."
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"The MEK and ERK MAPK pathway drives STAT3 (pS727) activation, and the c-KIT/PI3K/AKT/mTOR pathway induces STAT3 (pS727) phosphorylation, leading to expression of IDO and HIF-1alpha."
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"Meanwhile, the phosphorylation and activation of STAT3 could increase the transcription of HIF1A , encoding a hypoxia-inducible factor related to cytotoxic damage."
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"Serotonin (5-HT) phosphorylates Jak1, resulting in the phosphorylation of STAT3 which promotes ERK1/2 activation, Akt phosphorylation and HIF-1a expression (68) ."
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"Pre-treatment with soy isoflavones inhibits radiation induced Src and STAT3 phosphorylations and radiation induced HIF-1alpha expression in PC-3 cells."
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Modified STAT3 increases the amount of HIF1A. 4 / 4
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"STAT3 is required for both basal and growth signal induced expression of HIF-1alpha and targeting STAT3 with small-molecule inhibitor blocks HIF-1alpha and VEGF expression in vitro and inhibits tumor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"STAT-3 over-expression or IL-6 treatment significantly induced HIF-1alpha and VEGF expression; however, BITC substantially suppressed STAT-3 as well as STAT-3-induced HIF-1alpha and VEGF expression."
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"Our results show that over-expression of STAT-3 in BxPC-3 cells significantly increased the expression of HIF-1alpha and VEGF under hypoxia (XREF_FIG)."
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"(1) AG490 induced significant proliferation inhibition on Hep-2 cells and Hep-2HIF-1alpha-/- cells in vitro underthe hypoxia environments (P < 0.05); (2) Suppressing expression of Stat3 reduced the expression of HIF-1alpha protein (P < 0.05); (3) Combined inhibition of Stat3 and HIF-1alpha enhanced radio- and chemo-sensitivity in laryngeal squamous carcinoma cells under hypoxia."
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STAT3 phosphorylated on Y705 increases the amount of HIF1A. 1 / 1
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"Nuclear PKM2 has been demonstrated to phosphorylate STAT3 at Tyr705 using a phosphate group from PEP, subsequently activating transcription of MEK5 [XREF_BIBR, XREF_BIBR] and HIF-1alpha [XREF_BIBR]."
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