IndraLab

Statements

Modified STAT3 increases the amount of HIF1A. 4 / 4
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"STAT3 is required for both basal and growth signal induced expression of HIF-1alpha and targeting STAT3 with small-molecule inhibitor blocks HIF-1alpha and VEGF expression in vitro and inhibits tumor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24388873
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"STAT-3 over-expression or IL-6 treatment significantly induced HIF-1alpha and VEGF expression; however, BITC substantially suppressed STAT-3 as well as STAT-3-induced HIF-1alpha and VEGF expression."
22016776
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"Our results show that over-expression of STAT-3 in BxPC-3 cells significantly increased the expression of HIF-1alpha and VEGF under hypoxia (XREF_FIG)."
22016776
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"(1) AG490 induced significant proliferation inhibition on Hep-2 cells and Hep-2HIF-1alpha-/- cells in vitro underthe hypoxia environments (P < 0.05); (2) Suppressing expression of Stat3 reduced the expression of HIF-1alpha protein (P < 0.05); (3) Combined inhibition of Stat3 and HIF-1alpha enhanced radio- and chemo-sensitivity in laryngeal squamous carcinoma cells under hypoxia."
26121837