IndraLab

Statements

RPS6KB1 phosphorylates RPS6KB1. 10 / 19
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"Immunoblot analysis of HCT116 extracts showed that Torin more completely blocked p70 s6k and 4EBP1 phosphorylation than rapamycin."
24927123
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"We had issues analyzing the phopsho-p70S6K as the p70S6K substrates are rapidly phosphorylated in the samples, while p70S6K unpredictable epitopes recognized by antibodies in some cases could not be phosphorylated by p70S6K [64]."
34445130
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"S6K1 Phosphorylates H2BS36 and S6K1 Mediated H2B Phosphorylation Induces Trimethylation of H3K27."
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"The inhibitor of RPS6KB1, LY2584702, significantly reduced the phosphorylation of RPS6KB1 and rpS6 in NSCLC cell lines."
28792981
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"Carbachol also induced phosphorylation of (Thr410) PKC zeta, (Ser473) Akt, and (Thr389) p70S6 kinase, and ethanol (50 mM) inhibited phosphorylation of PKC zeta and p70S6 kinase, but not of Akt."
12781924
sparser
"Active mTOR kinase inhibits autophagy and enhances protein synthesis (i) by upregulating p70S6 kinase which phosphorylates the ribosomal protein p70S6 and (ii) by downregulating the eukaryotic initiat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15104104
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"The data provide evidence for regulation of S6K1, where hydrophobic motif phosphorylation is not required for PDK1 to phosphorylate S6K1 at the activation loop, but instead activation loop phosphorylation of S6K1 is required for mTOR to phosphorylate the hydrophobic motif of S6K1."
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"Akt activates mammalian target rapamycin (mTOR), which induces the phosphorylation of p70 ribosomal S6 kinase (p70S6K)."
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"Inhibition of PI3K or mTOR and p70S6K by wortmannin and rapamycin, respectively, increased apoptosis and inhibited phosphorylation of Akt and p70S6K induced by oxidative stress XREF_BIBR."
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sparser
"The mTORC1 complex also activates many additional proteins including p70S6K, which then phosphorylates p70S6."
28187001
RPS6KB1 phosphorylates RPS6KB1 on T412. 10 / 11
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"In agreement with the known food dependent induction, phosphorylation of the mTORC1 target S6K1 on T389 increased after feeding (maximum of phosphorylation was observed at ZT14-ZT22) and then gradually reduced to the minimum level (at ZT6) during the rest period."
25239872
phosphoelm
No evidence text available
15388791
phosphoelm
No evidence text available
12183455
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"Consistent with our previous findings in HEK293 cells, incrementSin1 expression in DLD1 cells suppressed Akt Ser473 phosphorylation but had no effect on phosphorylation of the mTORC1 target p70S6K Thr389."
29156676
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"This was achieved by studying the phosphorylation of Akt residues governed by PI3K initiated events (Thr308) or by mTORC2 (Ser473) and the phosphorylation of mTORC1 targets p70S6K (Thr389) and 4E-BP1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24650799
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"Further, interference of p70S6K by DN-p70S6K abolished p70S6K phosphorylation at Thr 389 and resulted in increased OGG1 protein expression, confirming the role of mTOR pathway in the regulation of OGG[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20656472
biopax:phosphositeplus
No evidence text available
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"Expectedly, in normal fibroblasts, in contrast to A549 cells, AICAR induced phosphorylation of ACC at serine 79 and decreased mTOR activity, as indicated by the level of phosphorylation of the mTOR ta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21945951
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"To evaluate the implication of glucose on E2F1-induced mTORC1 activation, cells were glucose starved or not before E2F1 induction (OHT) and mTORC1 activity was analyzed by the phosphorylation of its downstream targets p70S6 kinase (pS6K T389) and S6 (pS6 S235/236)."
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"Results revealed that both RPS6KB1 and its phosphorylated protein p-RPS6KB1 at T389 were highly up-regulated in NSCLC tissues, compared with controls; but only the hyperphosphorylation independently predicted the adverse prognosis of NSCLC patients."
28792981
Kinase-active RPS6KB1 leads to the phosphorylation of RPS6KB1 on T412. 2 / 2
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bel
"Consistent with this, epidermal growth factor-induced Thr(389) phosphorylation in wild type S6K1 persisted for up to 120 min, whereas kinase-inactive mutants of S6K1 displayed only a reduced and transient increase in Thr(389) phosphorylation."
12183455
bel
"Consistent with this, epidermal growth factor-induced Thr(389) phosphorylation in wild type S6K1 persisted for up to 120 min, whereas kinase-inactive mutants of S6K1 displayed only a reduced and transient increase in Thr(389) phosphorylation."
12183455
RPS6KB1 phosphorylates RPS6KB1 on S447. 1 / 1
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"Accordingly, stimulated muscle contraction increased mTORC1 signaling in skeletal muscle of control mice; phosphorylation of S6K1 Thr 389 (8-fold), S6K1 Thr 421/Ser424 (7-fold), ribosomal protein S6 (rpS6) Ser 240/244 (8-fold), rpS6 Ser 235/236 10-fold) (data not shown), and 4E-BP1 Ser 65 11-fold) were all significantly increased 2h after muscle contraction (XREF_FIG)."
25423127
RPS6KB1 leads to the phosphorylation of RPS6KB1 on leucine. 1 / 1
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"Using immunofluorescence, we confirmed at the subcellular level that phosphorylation of both mTOR and its target S6K1 was dependent on intracellular leucine concentrations (see Supplemental data, Supp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22898570
Modified RPS6KB1 leads to the phosphorylation of RPS6KB1. 1 / 1
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"Thus, blocking PI3K by its inhibitor could vigorously inhibit infection of numerous viruses including LCMV19 and coxsackievirus.39 Over-expression of p70S6K or Akt stimulates mRNA expression of coxsackievirus B3 (CVB3).40 Rotavirus infection has been reported to activate phosphorylation of p70S6K in piglets."
28475412
RPS6KB1 leads to the phosphorylation of RPS6KB1 on tyrosine. 1 / 1
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"Interestingly, IGF-1R activation is capable of mediating the activation of mTOR/p70S6K both in vitro and in vivo and endogenous mTOR/p70S6K is tyrosine-phosphorylated in response to IGF-1 stimulation [42]."
30213025
Modified mutated RPS6KB1 leads to the phosphorylation of RPS6KB1. 1 / 1
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"Likewise, inhibition of S6K1 activity and rpS6 phosphorylation by overexpression of dominant negative S6K1 mutants failed to suppress the translational activation of TOP mRNAs in amino acid refed cells."
11713299
RPS6KB1-S6K leads to the phosphorylation of RPS6KB1-S6K. 1 / 1
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"The data presented here show that c48/80 : i) at low doses (up to 10 mug/ml) augments serum induced phosphorylation of PKB and p70 S6K in a manner sensitive to both PI 3-kinase and PKC inhibitors, ii)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16942862
RPS6KB1 leads to the phosphorylation of RPS6KB1 on S394. 1 / 1
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"Activation of mTOR substrates, including 4EBP1 and S6K1, which has two different phosphorylated sites p-S6K1 (Thr389) and p-S6K1 (Ser371), were detected to investigate the activation of mTOR signaling pathway."
30855348
RPS6KB1 phosphorylated on T412 leads to the phosphorylation of RPS6KB1 on T412. 1 / 1
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"P70S6K phosphorylation at Thr389 was significantly increased in response to EMS, whereas the LLE group showed significantly higher p70S6K phosphorylation at Thr389 than that in the CON group."
35783523
Phosphorylated RPS6KB1 leads to the phosphorylation of RPS6KB1. 1 / 1
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"In addition to the direct effect of stretching stimuli on p70S6K phosphorylation in myotubes, p70S6K could also be phosphorylated in stretched myotubes partially via an autocrine manner, because conditioned medium from stretched myotubes induced p70S6K phosphorylation in unstretched cells (Baar et al., 2000)."
34408658
RPS6KB1 phosphorylates RPS6KB1 on T444. 1 / 1
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"Accordingly, stimulated muscle contraction increased mTORC1 signaling in skeletal muscle of control mice; phosphorylation of S6K1 Thr 389 (8-fold), S6K1 Thr 421/Ser424 (7-fold), ribosomal protein S6 (rpS6) Ser 240/244 (8-fold), rpS6 Ser 235/236 10-fold) (data not shown), and 4E-BP1 Ser 65 11-fold) were all significantly increased 2h after muscle contraction (XREF_FIG)."
25423127
RPS6KB1 leads to the phosphorylation of RPS6KB1 on serine. 1 / 1
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"The results show that targeted pharmacologic interventions with DPP-4 inhibitor could be useful in ameliorating pathophysiologic abnormalities in cardiac diastolic dysfunction and preventing the activation of insulin metabolic signaling molecules through enhanced mTOR/S6K1 activation and Ser phosphorylation of IRS-1 and IRS-2."
30116740
Modified RPS6KB1 leads to the phosphorylation of RPS6KB1 on T412. 1 / 1
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"Our results demonstrate that Rheb regulation of mTOR signaling occurs, at least in part, through the direct binding of Rheb-GTP to mTOR, an interaction that promotes activation of the mTOR kinase acti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15854902
RPS6KB1 leads to the phosphorylation of RPS6KB1 on T252. 1 / 1
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"PI 3-kinase provides a signal necessary for the mitogen activation of the p70 S6 kinase, which directs the site specific phosphorylation of Thr 252 in the p70 catalytic domain, through a distinctive signal transduction pathway."
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