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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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RPS6KB1 phosphorylates RPS6KB1. 10 / 21
| 1 1 8 11
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"Nonetheless, contractions were still able to induce significant increases in p70 s6k phosphorylation even when IGF-I signaling is ablated in muscle."
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"Immunoblot analysis of HCT116 extracts showed that Torin more completely blocked p70 s6k and 4EBP1 phosphorylation than rapamycin."
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"S6K1 Phosphorylates H2BS36 and S6K1 Mediated H2B Phosphorylation Induces Trimethylation of H3K27."
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"The inhibitor of RPS6KB1, LY2584702, significantly reduced the phosphorylation of RPS6KB1 and rpS6 in NSCLC cell lines."
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"We observed significant dose- and time dependent increases in the phosphorylation of MTOR and its downstream substrates RPS6KB1 and p70S6K and EIF4EBP1 (XREF_FIG) in primary astrocytes."
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"Interestingly, we observed that the combination treatment in S6K1 E389 DeltaCT-HA failed to dephosphorylate Bad, which indicated consistently that S6K1 contributed to the phosphorylation of Bad and S6K1 and Bad played an important role in the combination of mitomycin C and rapamycin induced apoptosis."
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"Expression of DN-epsilonPKC abolished ET-1-stimulated mTOR and S6K1 phosphorylation, but not insulin stimulated S6K1 phosphorylation."
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"Carbachol also induced phosphorylation of (Thr410) PKC zeta, (Ser473) Akt, and (Thr389) p70S6 kinase, and ethanol (50 mM) inhibited phosphorylation of PKC zeta and p70S6 kinase, but not of Akt."
sparser
"Active mTOR kinase inhibits autophagy and enhances protein synthesis (i) by upregulating p70S6 kinase which phosphorylates the ribosomal protein p70S6 and (ii) by downregulating the eukaryotic initiat[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
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"The data provide evidence for regulation of S6K1, where hydrophobic motif phosphorylation is not required for PDK1 to phosphorylate S6K1 at the activation loop, but instead activation loop phosphorylation of S6K1 is required for mTOR to phosphorylate the hydrophobic motif of S6K1."
RPS6KB1 phosphorylates RPS6KB1 on T412. 9 / 9
| 5 4
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"Consistent with our previous findings in HEK293 cells, incrementSin1 expression in DLD1 cells suppressed Akt Ser473 phosphorylation but had no effect on phosphorylation of the mTORC1 target p70S6K Thr389."
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"In agreement with the known food dependent induction, phosphorylation of the mTORC1 target S6K1 on T389 increased after feeding (maximum of phosphorylation was observed at ZT14-ZT22) and then gradually reduced to the minimum level (at ZT6) during the rest period."
sparser
"This is an important point because it established that the PA-induced increase in p70 s6k T389 phosphorylation required the presence of mTOR and, therefore, did not result from the presence of a non-specific kinase that was pulled down during the immunoprecipitation procedure."
sparser
"Hence, observing a robust increase in p70 s6k T389 phosphorylation, in conjunction with no change in 4E-BP1 T36/45 phosphorylation, was highly unexpected."
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"Results revealed that both RPS6KB1 and its phosphorylated protein p-RPS6KB1 at T389 were highly up-regulated in NSCLC tissues, compared with controls; but only the hyperphosphorylation independently predicted the adverse prognosis of NSCLC patients."
sparser
"The results demonstrated that PA can induce an increase in p70 s6k T389 phosphorylation, and this only occurred in the immunoprecipitates obtained from the FLAG-mTOR cells."
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"Accordingly, stimulated muscle contraction increased mTORC1 signaling in skeletal muscle of control mice; phosphorylation of S6K1 Thr 389 (8-fold), S6K1 Thr 421/Ser424 (7-fold), ribosomal protein S6 (rpS6) Ser 240/244 (8-fold), rpS6 Ser 235/236 10-fold) (data not shown), and 4E-BP1 Ser 65 11-fold) were all significantly increased 2h after muscle contraction (XREF_FIG)."
sparser
"The immunoprecipitates were then subjected to an in-vitro mTOR kinase activity assay in which p70 s6k T389 phosphorylation was used as a readout of mTOR activity xref ."
sparser
"For example, the RR-mTOR mice enabled us to demonstrate that a mechanically-induced increase in p70 s6k T389 phosphorylation is fully dependent on mTOR."
Kinase-active RPS6KB1 leads to the phosphorylation of RPS6KB1 on T412. 2 / 2
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bel
"Consistent with this, epidermal growth factor-induced Thr(389) phosphorylation in wild type S6K1 persisted for up to 120 min, whereas kinase-inactive mutants of S6K1 displayed only a reduced and transient increase in Thr(389) phosphorylation."
bel
"Consistent with this, epidermal growth factor-induced Thr(389) phosphorylation in wild type S6K1 persisted for up to 120 min, whereas kinase-inactive mutants of S6K1 displayed only a reduced and transient increase in Thr(389) phosphorylation."
RPS6KB1 leads to the phosphorylation of RPS6KB1 on T252. 1 / 1
| 1
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"PI 3-kinase provides a signal necessary for the mitogen activation of the p70 S6 kinase, which directs the site specific phosphorylation of Thr 252 in the p70 catalytic domain, through a distinctive signal transduction pathway."
RPS6KB1 phosphorylates RPS6KB1 on T444. 1 / 1
| 1
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"Accordingly, stimulated muscle contraction increased mTORC1 signaling in skeletal muscle of control mice; phosphorylation of S6K1 Thr 389 (8-fold), S6K1 Thr 421/Ser424 (7-fold), ribosomal protein S6 (rpS6) Ser 240/244 (8-fold), rpS6 Ser 235/236 10-fold) (data not shown), and 4E-BP1 Ser 65 11-fold) were all significantly increased 2h after muscle contraction (XREF_FIG)."
RPS6KB1 phosphorylates RPS6KB1 on S447. 1 / 1
| 1
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"Accordingly, stimulated muscle contraction increased mTORC1 signaling in skeletal muscle of control mice; phosphorylation of S6K1 Thr 389 (8-fold), S6K1 Thr 421/Ser424 (7-fold), ribosomal protein S6 (rpS6) Ser 240/244 (8-fold), rpS6 Ser 235/236 10-fold) (data not shown), and 4E-BP1 Ser 65 11-fold) were all significantly increased 2h after muscle contraction (XREF_FIG)."
RPS6KB1 leads to the phosphorylation of RPS6KB1 on S394. 1 / 1
| 1
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"Activation of mTOR substrates, including 4EBP1 and S6K1, which has two different phosphorylated sites p-S6K1 (Thr389) and p-S6K1 (Ser371), were detected to investigate the activation of mTOR signaling pathway."
Modified mutated RPS6KB1 leads to the phosphorylation of RPS6KB1. 1 / 1
| 1
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"Likewise, inhibition of S6K1 activity and rpS6 phosphorylation by overexpression of dominant negative S6K1 mutants failed to suppress the translational activation of TOP mRNAs in amino acid refed cells."