IndraLab

Statements

RPS6KB1 phosphorylates RPS6KB1. 19 / 19
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"Immunoblot analysis of HCT116 extracts showed that Torin more completely blocked p70 s6k and 4EBP1 phosphorylation than rapamycin."
24927123
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"We had issues analyzing the phopsho-p70S6K as the p70S6K substrates are rapidly phosphorylated in the samples, while p70S6K unpredictable epitopes recognized by antibodies in some cases could not be phosphorylated by p70S6K [64]."
34445130
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"S6K1 Phosphorylates H2BS36 and S6K1 Mediated H2B Phosphorylation Induces Trimethylation of H3K27."
27151441
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"The inhibitor of RPS6KB1, LY2584702, significantly reduced the phosphorylation of RPS6KB1 and rpS6 in NSCLC cell lines."
28792981
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"Carbachol also induced phosphorylation of (Thr410) PKC zeta, (Ser473) Akt, and (Thr389) p70S6 kinase, and ethanol (50 mM) inhibited phosphorylation of PKC zeta and p70S6 kinase, but not of Akt."
12781924
sparser
"Active mTOR kinase inhibits autophagy and enhances protein synthesis (i) by upregulating p70S6 kinase which phosphorylates the ribosomal protein p70S6 and (ii) by downregulating the eukaryotic initiat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15104104
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"The data provide evidence for regulation of S6K1, where hydrophobic motif phosphorylation is not required for PDK1 to phosphorylate S6K1 at the activation loop, but instead activation loop phosphorylation of S6K1 is required for mTOR to phosphorylate the hydrophobic motif of S6K1."
21561857
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"Akt activates mammalian target rapamycin (mTOR), which induces the phosphorylation of p70 ribosomal S6 kinase (p70S6K)."
30853887
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"Inhibition of PI3K or mTOR and p70S6K by wortmannin and rapamycin, respectively, increased apoptosis and inhibited phosphorylation of Akt and p70S6K induced by oxidative stress XREF_BIBR."
23118851
sparser
"The mTORC1 complex also activates many additional proteins including p70S6K, which then phosphorylates p70S6."
28187001
sparser
"P70 s6k and 4E-BP1 phosphorylation are dependent on the availability of amino acids, in addition to a growth factor, in the medium."
11057898
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"Inhibition of PI3K or mTOR and p70S6K by wortmannin and rapamycin, respectively, increased apoptosis and inhibited phosphorylation of Akt and p70S6K induced by single-dose oxidative stress."
20230819
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"We observed significant dose- and time dependent increases in the phosphorylation of MTOR and its downstream substrates RPS6KB1 and p70S6K and EIF4EBP1 (XREF_FIG) in primary astrocytes."
27929536
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"Expression of DN-epsilonPKC abolished ET-1-stimulated mTOR and S6K1 phosphorylation, but not insulin stimulated S6K1 phosphorylation."
19168855
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"Interestingly, we observed that the combination treatment in S6K1 E389 DeltaCT-HA failed to dephosphorylate Bad, which indicated consistently that S6K1 contributed to the phosphorylation of Bad and S6K1 and Bad played an important role in the combination of mitomycin C and rapamycin induced apoptosis."
24901052
rlimsp
"c-Abl inhibits autophosphorylation of RAFT1 and RAFT1-mediated phosphorylation p70(S6k)."
10753870
trips
"Mammalian target of rapamycin (mTOR) is known to phosphorylate and thereby activate p70 S6K1."
21710263
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"Evidence has revealed overexpression of p70S6K and phosphorylated p70S6K (p-p70S6K) in various tumor tissues, with these proteins identified as independent prognostic markers in non-small cell lung cancer (NSCLC)."
26771549
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"Incubation of GST-p70S6K1 with Flag-mTOR increased S6K1 phosphorylation compared to control cells."
28270148