"Nonetheless, contractions were still able to induce significant increases in p70 s6k phosphorylation even when IGF-I signaling is ablated in muscle."
"Immunoblot analysis of HCT116 extracts showed that Torin more completely blocked p70 s6k and 4EBP1 phosphorylation than rapamycin."
"S6K1 Phosphorylates H2BS36 and S6K1 Mediated H2B Phosphorylation Induces Trimethylation of H3K27."
"The inhibitor of RPS6KB1, LY2584702, significantly reduced the phosphorylation of RPS6KB1 and rpS6 in NSCLC cell lines."
"We observed significant dose- and time dependent increases in the phosphorylation of MTOR and its downstream substrates RPS6KB1 and p70S6K and EIF4EBP1 (XREF_FIG) in primary astrocytes."
"Interestingly, we observed that the combination treatment in S6K1 E389 DeltaCT-HA failed to dephosphorylate Bad, which indicated consistently that S6K1 contributed to the phosphorylation of Bad and S6K1 and Bad played an important role in the combination of mitomycin C and rapamycin induced apoptosis."
"Expression of DN-epsilonPKC abolished ET-1-stimulated mTOR and S6K1 phosphorylation, but not insulin stimulated S6K1 phosphorylation."
"Carbachol also induced phosphorylation of (Thr410) PKC zeta, (Ser473) Akt, and (Thr389) p70S6 kinase, and ethanol (50 mM) inhibited phosphorylation of PKC zeta and p70S6 kinase, but not of Akt."
"Active mTOR kinase inhibits autophagy and enhances protein synthesis (i) by upregulating p70S6 kinase which phosphorylates the ribosomal protein p70S6 and (ii) by downregulating the eukaryotic initiat[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
"The data provide evidence for regulation of S6K1, where hydrophobic motif phosphorylation is not required for PDK1 to phosphorylate S6K1 at the activation loop, but instead activation loop phosphorylation of S6K1 is required for mTOR to phosphorylate the hydrophobic motif of S6K1."
"The mTORC1 complex also activates many additional proteins including p70S6K, which then phosphorylates p70S6."
"c-Abl inhibits autophosphorylation of RAFT1 and RAFT1-mediated phosphorylation p70(S6k)."
"p70 s6k and 4E-BP1 phosphorylation are dependent on the availability of amino acids, in addition to a growth factor, in the medium."
"Indeed, recent findings indicate that contraction-induced p70 s6k phosphorylation is attenuated in rodent models that develop obesity and/or insulin resistance [ xref ]."
"Inhibition of PI3K or mTOR and p70S6K by wortmannin and rapamycin, respectively, increased apoptosis and inhibited phosphorylation of Akt and p70S6K induced by single-dose oxidative stress."
"Akt activates mammalian target rapamycin (mTOR), which induces the phosphorylation of p70 ribosomal S6 kinase (p70S6K)."
"Inhibition of PI3K or mTOR and p70S6K by wortmannin and rapamycin, respectively, increased apoptosis and inhibited phosphorylation of Akt and p70S6K induced by oxidative stress XREF_BIBR."
"The animals also respond poorly to glucose challenges and are proposed to be a model of type 2 diabetes [ xref ], thus it is possible that reduced levels of p70 s6k phosphorylation in response to the mechanical load is a result of the metabolic dysfunction."
"Mammalian target of rapamycin (mTOR) is known to phosphorylate and thereby activate p70 S6K1."
"Evidence has revealed overexpression of p70S6K and phosphorylated p70S6K (p-p70S6K) in various tumor tissues, with these proteins identified as independent prognostic markers in non-small cell lung cancer (NSCLC)."
"Incubation of GST-p70S6K1 with Flag-mTOR increased S6K1 phosphorylation compared to control cells."