IndraLab

Statements

ZRANB1 affects EZH2
| 3
ZRANB1 deubiquitinates EZH2. 2 / 2
| 2
reach
"To further determine whether ZRANB1 directly deubiquitinates EZH2, we incubated purified ZRANB1 and ubiquitinated EZH2 purified from ZRANB1-knockout HEK293A cells in a cell-free system."
29669287
reach
"ZRANB1 purified from insect cells markedly decreased EZH2 polyubiquitination in vitro (XREF_FIG), suggesting that EZH2 is a substrate of ZRANB1."
29669287
Modified ZRANB1 leads to the deubiquitination of EZH2. 1 / 1
| 1
reach
"Indeed, overexpression of ZRANB1 in ZRANB1-knockout HEK293A cells substantially reduced EZH2 polyubiquitination (XREF_FIG, denaturing condition)."
29669287
ZRANB1 affects PIK3C3
| 2
ZRANB1 leads to the deubiquitination of PIK3C3 on K29. 2 / 2
| 2
reach
"TRABID antagonizes VPS34 K29 and K48 heterotypic ubiquitination even though it can not hydrolyze unanchored K48 diubiquitin chains 37."
33637724
reach
"TRABID reduces VPS34 K29 and K48 ubiquitination to stabilize VPS34."
33637724
ZRANB1 affects KDM4D
| 2
ZRANB1 leads to the deubiquitination of KDM4D. 2 / 2
| 2
reach
"When transfected into HEK293 cells, wild-type Trabid, but not C443A Trabid, inhibited Jmjd2d ubiquitination (XREF_FIG), and the transfected Jmjd2d was abundantly conjugated with both K11- and K29 linked polyubiquitin chains (XREF_FIG)."
26808229
reach
"DC-cKO BMDCs had markedly more abundant Jmjd2d ubiquitination than the wild-type BMDCs (XREF_FIG), suggesting that Trabid negatively regulated Jmjd2d ubiquitination."
26808229
ZRANB1 affects APC
| 2
ZRANB1 deubiquitinates APC. 2 / 2
| 2
reach
"Trabid binds to and deubiquitylates APC."
24594309
reach
"For example, Trabid and Cezanne, both deubiquitinating (DUB) enzymes, antagonize the ubiquitination of APC, resulting in activation of beta-catenin and TCF-mediated transcription."
21118991
ZRANB1 affects UVRAG
1 |
ZRANB1 deubiquitinates UVRAG. 1 / 1
1 |
ubibrowser
"However, the deubiquitinase ZRANB1 specifically cleaves SMURF1-induced K29 and K33-linked polyubiquitin chains from UVRAG, thereby increasing the binding of UVRAG to RUBCN and inhibiting autophagy flux."
30686098
ZRANB1 affects TUMOR-SUPPRESSOR-PROTEIN
| 1
ZRANB1 deubiquitinates TUMOR-SUPPRESSOR-PROTEIN. 1 / 1
| 1
trips
"We further show that Trabid can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription."
18281465
ZRANB1 affects MAP3K7
| 1
ZRANB1 leads to the deubiquitination of MAP3K7. 1 / 1
| 1
reach
"Trabid has also been shown to interact with and inhibits K63 ubiquitination of Drosophila TAK1, reducing the expression of downstream genes encoding antimicrobial peptides in flies 42."
26808229
ZRANB1 affects DDB2
| 1
ZRANB1 deubiquitinates DDB2. 1 / 1
| 1
reach
"Furthermore, TRABID deubiquitinates DDB2, and this deubiquitination effect of TRABID depends on its active site."
35944360
ZRANB1 affects APC tumor suppressor protein
| 1
ZRANB1 deubiquitinates APC tumor suppressor protein. 1 / 1
| 1
reach
"We further show that Trabid can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt mediated transcription."
18281465