IndraLab

Statements


YOD1 affects ITCH
1 | 3
YOD1 deubiquitinates ITCH. 4 / 4
1 | 3

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"A recent study reported that YOD1 could deubiquitinate ITCH, and enhanced the stability of ITCH, which subsequently reduced the levels of LATS and increased the YAP/TAZ level."

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"Mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS, and enhances the stability of ITCH, which leads to reduced levels of LATS and a subsequent increase in the YAP and TAZ level."

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"Mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS, and enhances the stability of ITCH, which leads to reduced levels of LATS and a subsequent increase in the YAP and TAZ level."

"Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability"
YOD1 affects VCP
1 | 2
YOD1 deubiquitinates VCP. 3 / 3
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"P97 QQ associated polyubiquitinated proteins can be deubiquitinated in vitro by purified YOD1 (XREF_SUPPLEMENTARY)."

"The activity of the p97-associated deubiquitinylase YOD1 is also required for substrate disposal."

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"Ataxin-3 and YOD1 promote the deubiquitination of p97 associated ERAD substrates, and facilitate delivery to the proteasome [21-24]."
YOD1 affects TRAF6
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YOD1 leads to the deubiquitination of TRAF6. 1 / 1
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"Another DUB, YOD1 (also called Otud2), inhibits TRAF6 ubiquitination and signaling function via a non-catalytic mechanism that involves binding to the C-terminal TRAF domain of TRAF6 and, thereby, preventing TRAF6 interaction with an activating adaptor protein, p62 (also called Sequestosome-1) (67)."
YOD1-C160S leads to the deubiquitination of TRAF6. 1 / 1
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"Also, catalytically inactive YOD1 C160S impaired the boost of TRAF6 auto-ubiquitination by p62, even though the inhibition was not quite as severe as with YOD1 WT."
YOD1 affects SYVN1
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YOD1 deubiquitinates SYVN1. 2 / 2
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"In both of these scenarios, YOD1 would deubiquitinate Hrd1."

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"If the cross-links represent Hrd1 oligomers, it is tempting to speculate that ubiquitination of Hrd1 favors its oligomerization; deubiquitination of Hrd1 by YOD1 would therefore prevent Hrd1 oligomerization."
YOD1 affects DES
1 | 1
YOD1 deubiquitinates DES. 2 / 2
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"YOD1, a DUB from OTU family, deubiquitinates desmin."

"YOD1, a DUB from OTU family, deubiquitinates desmin."
YOD1 affects α-synuclein
| 1
YOD1 deubiquitinates α-synuclein. 1 / 1
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"Deubiquitinating enzyme YOD1 deubiquitinates and destabilizes α-synuclein."
YOD1 affects phospho-Smad2/3
| 1
YOD1 leads to the deubiquitination of phospho-Smad2/3. 1 / 1
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"YOD1 siRNA may enhance the ubiquitylation of TGF-β3 and phospho-Smad2/3 and then result in the downregulation of TGF-β signaling.The mechanism of inhibition of cell proliferation and migration caused by YOD1 siRNA may be associated with TGF-β3 signaling pathway, which is involved in NSCL/P."
YOD1 affects TGFB
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YOD1 leads to the deubiquitination of TGFB. 1 / 1
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"YOD1 siRNA may enhance the ubiquitylation of TGF-β3 and phospho-Smad2/3 and then result in the downregulation of TGF-β signaling.The mechanism of inhibition of cell proliferation and migration caused by YOD1 siRNA may be associated with TGF-β3 signaling pathway, which is involved in NSCL/P."
YOD1 affects NEDD4
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YOD1 deubiquitinates NEDD4. 1 / 1
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"YOD1 Deubiquitinates NEDD4 Involved in the Hippo Signaling Pathway."
YOD1 affects K6-, K11-, K29-, K33-,
| 1
YOD1 deubiquitinates K6-, K11-, K29-, K33-, on K63. 1 / 1
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"In the current study, we found that YOD1 directly interacts with α-synuclein and deubiquitinates K6-, K11-, K29-, K33-, and K63-linked polyubiquitin chains on α-synuclein."
YOD1 affects Gln-Gln
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YOD1 deubiquitinates Gln-Gln. 1 / 1
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"p97 QQ associated polyubiquitinated proteins can be deubiquitinated in vitro by purified YOD1 (XREF_SUPPLEMENTARY)."
YOD1 affects CTA1
| 1
YOD1 leads to the deubiquitination of CTA1. 1 / 1
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"Because YOD1 knockdown did not promote CTA1 ubiquitination, despite increasing total cellular polyubiquitinated proteins, we propose that YOD1 imposes its negative role by deubiquitinating components of the ERAD machinery that normally promote retro translocation when ubiquitinated (XREF_FIG)."