IndraLab

Statements

USP51 affects ZEB1
1 | 2
USP51 leads to the deubiquitination of ZEB1. 3 / 3
1 | 2
ubibrowser
"By screening a human deubiquitinase library, we identified USP51 as a deubiquitinase that binds, deubiquitinates, and stabilizes ZEB1."
29119051
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"Lastly, knockdown of USP51 promoted ZEB1 ubiquitination, leading to ZEB1 degradation."
32468048
reach
"USP51 promotes deubiquitination and stabilization of ZEB1."
29119051
USP51 affects TWIST1
| 3
USP51 deubiquitinates TWIST1. 3 / 3
| 3
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"Our results show that USP51 maintains the stemness of NSCLC cells by deubiquitinating TWIST1."
37422632
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"We found that USP51 deubiquitinates TWIST1, which is significantly upregulated in the tissues of patients with NSCLC and is closely associated with poor prognosis."
37422632
reach
"USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1."
37422632
USP51 affects Histone_H2B
| 3
USP51 deubiquitinates Histone_H2B. 3 / 3
| 3
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"Remarkably, this inhibitor also showed greater activity on USP22 than on two other DUBs, USP27x and USP51, that also deubiquitinate histone H2B and form complexes with two of the SAGA DUB module adaptor subunits."
34936860
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"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that the ATXN7L3 zinc finger plays a role analogous to that of the Sgf11 zinc finger in docking human SAGA DUB [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27923209
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"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that all three use the ATXN7L3 zinc finger to dock the H2A and H2B acidic patch in a manner similar to that shown in the structure of the yeast DUB module bound to ubiquitinated nucleosomes."
27923209
USP51 affects H2AK13,15ub
| 3
USP51 deubiquitinates H2AK13,15ub. 3 / 3
| 3
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"Here we show that USP51, a previously uncharacterized DUB, deubiquitylates H2AK13,15 ub and regulates DNA damage response."
27083998
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"In vitro, USP51 binds to H2A-H2B directly and deubiquitylates H2AK13,15 ub."
27083998
reach
"USP51 deubiquitylates H2AK13,15 ub and regulates DNA damage response."
27083998
USP51 affects H2Aub1
| 2
USP51 deubiquitinates H2Aub1. 2 / 2
| 2
reach
"As was previously shown for the USP22 DUBm, both USP27X and USP51 DUBm also deubiquitinated nucleosomal or free H2Aub1 (XREF_FIG and XREF_SUPPLEMENTARY)."
27132940
reach
"As was previously shown for the USP22 DUBm (Zhang et al., 2008a; Zhao et al., 2008), both USP27X and USP51 DUBm also deubiquitinated nucleosomal or free H2Aub1."
27132940
USP51 affects TP53BP1
| 1
USP51 leads to the deubiquitination of TP53BP1. 1 / 1
| 1
reach
"Overexpression of USP51 suppresses H2A ubiquitination as well as 53BP1 and BRCA1, but not RNF168 IRIF formation."
33797206
USP51 affects H2BK120Ub
| 1
USP51 deubiquitinates H2BK120Ub. 1 / 1
| 1
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"Further experiments established that USP51 in vitro could deubiquitinate a nucleosome carrying H2BK120Ub, but not H2BK34Ub."
30192049
USP51 affects H2BC10
1 |
USP51 deubiquitinates H2BC10. 1 / 1
1 |
ubibrowser
"In contrast, depletion of non-enzymatic components, ATXN7L3 or ENY2, results in increased H2Bub1. These observations led us to discover two H2Bub1 DUBs, USP27X and USP51, which function independently of SAGA and compete with USP22 for ATXN7L3 and ENY2 for activity."
27132940
USP51 affects H2AX
| 1
USP51 deubiquitinates H2AX. 1 / 1
| 1
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"USP3, USP51 and USP16 de-ubiquitinate H2A/H2AX with varying degrees of specificity [47–49]."
31769469
USP51 affects H2AC20
1 |
USP51 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response."
27083998
USP51 affects BRCA1
| 1
USP51 leads to the deubiquitination of BRCA1. 1 / 1
| 1
reach
"Overexpression of USP51 suppresses H2A ubiquitination as well as 53BP1 and BRCA1, but not RNF168 IRIF formation."
33797206