IndraLab

Statements


USP51 affects ZEB1
1 | 2
USP51 leads to the deubiquitination of ZEB1. 3 / 3
1 | 2

"By screening a human deubiquitinase library, we identified USP51 as a deubiquitinase that binds, deubiquitinates, and stabilizes ZEB1."

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"Lastly, knockdown of USP51 promoted ZEB1 ubiquitination, leading to ZEB1 degradation."

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"USP51 promotes deubiquitination and stabilization of ZEB1."
USP51 affects H2AK13,15ub
| 3
USP51 deubiquitinates H2AK13,15ub. 3 / 3
| 3

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"Here we show that USP51, a previously uncharacterized DUB, deubiquitylates H2AK13,15 ub and regulates DNA damage response."

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"In vitro, USP51 binds to H2A-H2B directly and deubiquitylates H2AK13,15 ub."

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"USP51 deubiquitylates H2AK13,15 ub and regulates DNA damage response."
USP51 affects Histone_H2B
| 2
USP51 deubiquitinates Histone_H2B. 2 / 2
| 2

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"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that all three use the ATXN7L3 zinc finger to dock the H2A and H2B acidic patch in a manner similar to that shown in the structure of the yeast DUB module bound to ubiquitinated nucleosomes."

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"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that the ATXN7L3 zinc finger plays a role analogous to that of the Sgf11 zinc finger in docking human SAGA DUB [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
USP51 affects H2Aub1
| 2
USP51 deubiquitinates H2Aub1. 2 / 2
| 2

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"As was previously shown for the USP22 DUBm, both USP27X and USP51 DUBm also deubiquitinated nucleosomal or free H2Aub1 (XREF_FIG and XREF_SUPPLEMENTARY)."

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"As was previously shown for the USP22 DUBm (Zhang et al., 2008a; Zhao et al., 2008), both USP27X and USP51 DUBm also deubiquitinated nucleosomal or free H2Aub1."
USP51 affects H2BK120Ub
| 1
USP51 deubiquitinates H2BK120Ub. 1 / 1
| 1

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"Further experiments established that USP51 in vitro could deubiquitinate a nucleosome carrying H2BK120Ub, but not H2BK34Ub."
USP51 affects H2BC10
1 |
USP51 deubiquitinates H2BC10. 1 / 1
1 |

"In contrast, depletion of non-enzymatic components, ATXN7L3 or ENY2, results in increased H2Bub1. These observations led us to discover two H2Bub1 DUBs, USP27X and USP51, which function independently of SAGA and compete with USP22 for ATXN7L3 and ENY2 for activity."
USP51 affects H2AC20
1 |
USP51 deubiquitinates H2AC20. 1 / 1
1 |

"USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response."