IndraLab

Statements

STAMBP affects EGFR
12 1 | 5
STAMBP deubiquitinates EGFR. 6 / 6
1 | 5
reach
"13 This implies that AMSH is able to completely deubiquitinate EGFR, since monoubiquitinated EGFR can still be targeted to lysosome."
21888914
reach
"STAMBP may deubiquitinate EGFR by localizing in early endosomes and increase EGFR membrane localization in LUAD cells."
34102455
reach
"AMSH can deubiquitinate EGFR and prompt recycling to the plasma membrane [XREF_BIBR], whilst USP8 is required for the degradation of EGFR in the lysosome [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25026282
reach
"In support of this notion, we are able to show that EGFR, immunoprecipitated from EGF stimulated Her14 cells, can be deubiquitinated by AMSH in vitro."
15314065
reach
"AMSH was shown to deubiquitylate in vitro EGFR immunoprecipitated from EGF stimulated cells [XREF_BIBR], and siRNA knockdown of AMSH resulted in accelerated EGFR degradation in HeLa cells, which suggests that AMSH dependent deubiquitylation of EGFR counteracts Cbl dependent ubiquitylation of the receptor [XREF_BIBR]."
25396681
ubibrowser
"AMSH (associated molecule with the SH3 domain of STAM) expression is elevated in many cancers and is capable of hydrolyzing K63-linked Ub chains from epidermal growth factor receptor (EGFR) recycling it to the plasma membrane"
25121098
STAMBP deubiquitinates EGFR phosphorylated on Y1172, Y1110, K867, K754, K929, Y1092, Y1016, K716, Y1197, K970, and Y1069 on K737. 2 / 2
2 |
biopax:pid
No evidence text available
17052190
biopax:pid
No evidence text available
15314065
STAMBP deubiquitinates EGFR phosphorylated on Y1172, Y1110, K867, K737, K754, K929, Y1092, Y1016, Y1197, K970, and Y1069 on K716. 2 / 2
2 |
biopax:pid
No evidence text available
17052190
biopax:pid
No evidence text available
15314065
STAMBP deubiquitinates EGFR phosphorylated on Y1172, Y1110, K867, K737, K929, Y1092, Y1016, K716, Y1197, K970, and Y1069 on K754. 2 / 2
2 |
biopax:pid
No evidence text available
15314065
biopax:pid
No evidence text available
17052190
STAMBP deubiquitinates EGFR phosphorylated on Y1172, Y1110, K867, K737, K754, Y1092, Y1016, K716, Y1197, K970, and Y1069 on K929. 2 / 2
2 |
biopax:pid
No evidence text available
15314065
biopax:pid
No evidence text available
17052190
STAMBP deubiquitinates EGFR phosphorylated on Y1172, Y1110, K867, K737, K754, K929, Y1092, Y1016, K716, Y1197, and Y1069 on K970. 2 / 2
2 |
biopax:pid
No evidence text available
17052190
biopax:pid
No evidence text available
15314065
STAMBP deubiquitinates EGFR phosphorylated on Y1172, Y1110, K737, K754, K929, Y1092, Y1016, K716, Y1197, K970, and Y1069 on K867. 2 / 2
2 |
biopax:pid
No evidence text available
15314065
biopax:pid
No evidence text available
17052190
STAMBP affects NLRP7
| 7
STAMBP deubiquitinates NLRP7. 7 / 7
| 7
reach
"This finding supports that STAMBP is sufficient to directly deubiquitinate NALP7."
28492230
reach
"STAMBP is sufficient to deubiquitinate NALP7 and is necessary to stabilize NALP7 protein in cells exposed to LPS or Pam3CSK4."
28492230
reach
"We next tested inhibition of STAMBP DUB activity specific to Ub-NALP7; here inclusion of BC-1471 blocked STAMBP mediated deubiquitination of Ub-NALP7 in vitro in a concentration dependent manner (XREF_FIG), where BC-1471 performed comparably to the broad-spectrum metalloprotease DUB inhibitor 1,10-phenanthroline."
28492230
reach
"Bednash et al.75 showed that the DUB STAMPBP (or AMSH) deubiquitinates NLRP7 rescuing this receptor from progressing to lysosome degradation and making it available for the formation of an active inflammasome.NLRC4 inflammasome activation can also be controlled by ubiquitination, although very little is known about how this occurs."
31679183
reach
"BC-1471 (43) was discovered as a specific STAMBP inhibitor (IC 50 = 0.33 muM) that selectively blocked deubiquitination of Ub-NALP7 by recombinant STAMBP [XREF_BIBR] but did not significantly inhibit the activity of a panel of 38 different DUBs at the concentration tested."
32196552
reach
"Since STAMBP is known to function as a DUB, we developed a cell-free DUB assay to test STAMBP deubiquitination of NALP7."
28492230
reach
"Bednash et al. 75 showed that the DUB STAMPBP (or AMSH) deubiquitinates NLRP7 rescuing this receptor from progressing to lysosome degradation and making it available for the formation of an active inflammasome."
31679183
STAMBP affects NLRP3
| 4
STAMBP deubiquitinates NLRP3. 4 / 4
| 4
reach
"3.3 STAMBP deubiquitinates NLRP3 but does not regulate its degradation.."
33253913
reach
"We hypothesized that STAMBP deubiquitinates NLRP3, which modulates NLRP3 activity."
33253913
reach
"STAMBP deubiquitinates NLRP3."
33253913
reach
"Therefore, the deubiquitination of NLRP3 by STAMBP acts as a negative regulator for NLRP3 inflammasome activation [109] 5.1.3."
| PMC
STAMBP affects F2RL1
1 | 1
STAMBP leads to the deubiquitination of F2RL1. 2 / 2
1 | 1
reach
"USP8 and AMSH mediate deubiquitination of PAR2 and its sorting from endosomes to lysosomes [XREF_BIBR]."
28448471
ubibrowser
"Expression of the catalytically inactive mutants, AMSH(D348A) and UBPY(C786S), caused an increase in PAR(2) ubiquitination and trapped the receptor in early endosomes, thereby preventing lysosomal trafficking and degradation."
19684015
STAMBP affects v-SNARE
| 1
STAMBP deubiquitinates v-SNARE. 1 / 1
| 1
reach
"XREF_BIBR; XREF_BIBR; XREF_BIBR; XREF_BIBR During mitosis, AMSH deubiquitinates v-SNARE and VAMP8 in an ESCRT dependent manner, while also being present in the early phases of cytokinesis, both implicating a potential role of AMSH as a regulator of proliferation and survival."
21888914
STAMBP affects VAMP8
| 1
STAMBP deubiquitinates VAMP8. 1 / 1
| 1
reach
"XREF_BIBR; XREF_BIBR; XREF_BIBR; XREF_BIBR During mitosis, AMSH deubiquitinates v-SNARE and VAMP8 in an ESCRT dependent manner, while also being present in the early phases of cytokinesis, both implicating a potential role of AMSH as a regulator of proliferation and survival."
21888914
STAMBP affects K63Ub chains
| 1
STAMBP deubiquitinates K63Ub chains. 1 / 1
| 1
reach
"AMSH, which belongs to the JAMM-domain metalloprotease family of DUBs, specifically deubiquitylates K63Ub chains."
22493318
STAMBP affects GJA1
1 |
STAMBP deubiquitinates GJA1. 1 / 1
1 |
ubibrowser
"AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions"
25070368
STAMBP affects GCGR
| 1
STAMBP deubiquitinates GCGR. 1 / 1
| 1
reach
"Therefore, deubiquitination of the GCGR by STAMBP after acute exposure to glucagon may not critically influence GCGR trafficking to the lysosomes."
32967969
STAMBP affects ERVK-18
| 1
STAMBP deubiquitinates ERVK-18. 1 / 1
| 1
reach
"Strikingly, co-expression of EGFR-ErbB2 TM together with AMSH D348A did not result in enhanced receptor ubiquitination, indicating that AMSH does not substantially deubiquitinate the EGFR-ErbB2 TM chi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22800866
STAMBP affects EPS15
| 1
STAMBP leads to the deubiquitination of EPS15. 1 / 1
| 1
reach
"This means that RNF11 could promote the internalisation and degradation of the EGFR via two distinct mechanisms, either by degradation of AMSH and/or mediating the mono-ubiquitination of EPS-15."
16226459
STAMBP affects EGFR-ERBB4 CYT-2 isoform
| 1
STAMBP deubiquitinates EGFR-ERBB4 CYT-2 isoform. 1 / 1
| 1
reach
"As expected, the non-K63-ubiquitinated EGFR-ERBB4 CYT-2 isoform was also not deubiquitinated by AMSH (results not shown)."
23153581
STAMBP affects EGFR-ERBB4 CYT-1
| 1
STAMBP deubiquitinates EGFR-ERBB4 CYT-1. 1 / 1
| 1
reach
"In contrast, no effect of cotransfection of AMSH D348A was observed on the level of ubiquitination of EGFR-ERBB4 CYT-1, indicating that AMSH does not substantially deubiquitinate the K63-polyubiquitin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23153581
STAMBP affects ART4
| 1
STAMBP leads to the deubiquitination of ART4. 1 / 1
| 1
reach
"In addition, Art4-AMSH exhibited an intermediate reduction in ubp2Delta ubp15Delta cells (XREF_FIG, lanes 7 and 8, and C), suggesting partial inhibition of Art4 hyperubiquitination by AMSH."
28298493