IndraLab

Statements

STAMBP deubiquitinates NLRP7. 7 / 7
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reach
"This finding supports that STAMBP is sufficient to directly deubiquitinate NALP7."
28492230
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"STAMBP is sufficient to deubiquitinate NALP7 and is necessary to stabilize NALP7 protein in cells exposed to LPS or Pam3CSK4."
28492230
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"We next tested inhibition of STAMBP DUB activity specific to Ub-NALP7; here inclusion of BC-1471 blocked STAMBP mediated deubiquitination of Ub-NALP7 in vitro in a concentration dependent manner (XREF_FIG), where BC-1471 performed comparably to the broad-spectrum metalloprotease DUB inhibitor 1,10-phenanthroline."
28492230
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"Bednash et al.75 showed that the DUB STAMPBP (or AMSH) deubiquitinates NLRP7 rescuing this receptor from progressing to lysosome degradation and making it available for the formation of an active inflammasome.NLRC4 inflammasome activation can also be controlled by ubiquitination, although very little is known about how this occurs."
31679183
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"BC-1471 (43) was discovered as a specific STAMBP inhibitor (IC 50 = 0.33 muM) that selectively blocked deubiquitination of Ub-NALP7 by recombinant STAMBP [XREF_BIBR] but did not significantly inhibit the activity of a panel of 38 different DUBs at the concentration tested."
32196552
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"Since STAMBP is known to function as a DUB, we developed a cell-free DUB assay to test STAMBP deubiquitination of NALP7."
28492230
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"Bednash et al. 75 showed that the DUB STAMPBP (or AMSH) deubiquitinates NLRP7 rescuing this receptor from progressing to lysosome degradation and making it available for the formation of an active inflammasome."
31679183