IndraLab

Statements

STAMBP deubiquitinates EGFR. 8 / 9
1 | 8
reach
"AMSH can deubiquitinate EGFR that has been immunoprecipitated from EGF-stimulated cells [31,37] ."
16996268
reach
"AMSH can deubiquitinate EGFR and prompt recycling to the plasma membrane [XREF_BIBR], whilst USP8 is required for the degradation of EGFR in the lysosome [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25026282
reach
"In support of this notion, we are able to show that EGFR, immunoprecipitated from EGF stimulated Her14 cells, can be deubiquitinated by AMSH in vitro."
15314065
reach
"STAMBP may deubiquitinate EGFR by localizing in early endosomes and increase EGFR membrane localization in LUAD cells."
34102455
reach
"13 This implies that AMSH is able to completely deubiquitinate EGFR, since monoubiquitinated EGFR can still be targeted to lysosome."
21888914
reach
"AMSH modulates the deubiquitination of the EGF receptor, thereby inhibiting its inclusion in the luminal vesicles of endosomes and instead promoting its recycling to the plasma membrane [249,250] ."
26855059
reach
"AMSH was shown to deubiquitylate in vitro EGFR immunoprecipitated from EGF stimulated cells [XREF_BIBR], and siRNA knockdown of AMSH resulted in accelerated EGFR degradation in HeLa cells, which suggests that AMSH dependent deubiquitylation of EGFR counteracts Cbl dependent ubiquitylation of the receptor [XREF_BIBR]."
25396681
reach
"Besides, STAMBP can deubiquitinate epidermal growth factor receptor (EGFR) and trigger mitogen-activated protein kinase signaling by increasing EGFR stability to promote lung adenocarcinoma metastasis [36]."
40180620