IndraLab

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STAMBP deubiquitinates EGFR. 9 / 9
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"AMSH can deubiquitinate EGFR that has been immunoprecipitated from EGF-stimulated cells [31,37] ."
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"AMSH can deubiquitinate EGFR and prompt recycling to the plasma membrane [XREF_BIBR], whilst USP8 is required for the degradation of EGFR in the lysosome [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"In support of this notion, we are able to show that EGFR, immunoprecipitated from EGF stimulated Her14 cells, can be deubiquitinated by AMSH in vitro."
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"STAMBP may deubiquitinate EGFR by localizing in early endosomes and increase EGFR membrane localization in LUAD cells."
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"13 This implies that AMSH is able to completely deubiquitinate EGFR, since monoubiquitinated EGFR can still be targeted to lysosome."
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"AMSH modulates the deubiquitination of the EGF receptor, thereby inhibiting its inclusion in the luminal vesicles of endosomes and instead promoting its recycling to the plasma membrane [249,250] ."
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"<span class="match term0">STAMBP</span> may deubiquitinate <span class="match term1">EGFR</span> by localizing in early endosomes and increase EGFR membrane localization in LUAD cells."
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"AMSH was shown to deubiquitylate in vitro EGFR immunoprecipitated from EGF stimulated cells [XREF_BIBR], and siRNA knockdown of AMSH resulted in accelerated EGFR degradation in HeLa cells, which suggests that AMSH dependent deubiquitylation of EGFR counteracts Cbl dependent ubiquitylation of the receptor [XREF_BIBR]."
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"Besides, STAMBP can deubiquitinate epidermal growth factor receptor (EGFR) and trigger mitogen-activated protein kinase signaling by increasing EGFR stability to promote lung adenocarcinoma metastasis [36]."
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