IndraLab

Statements

MINDY1 affects YAP1
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MINDY1 deubiquitinates YAP1. 3 / 3
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"Then, we examined MINDY1 deubiquitination activity on YAP in two common ubiquitination manners (K48-linked ubiquitination and K63-linked ubiquitination)."
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"MINDY1 deubiquitylates YAP."
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"Conversely, ectopic expression of MINDY1-WT, but not MINDY1 , markedly decreased YAP ubiquitylation in cells (Fig. 4B)."
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MINDY1 affects ESR1
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MINDY1 deubiquitinates ESR1. 3 / 3
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"Specifically, MINDY1 associated with the N-terminal of ERalpha via its catalytic domain, thus inhibiting K48-specific poly-ubiquitination process on ERalpha protein."
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"MINDY1 deubiquitylates ERalpha."
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"MINDY1 interacted with ERalpha, thereby mediating the deubiquitination of ERalpha and increased its stability in a deubiquitylation activity-dependent manner."
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MINDY1 affects ESR
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MINDY1 leads to the deubiquitination of ESR. 3 / 3
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"As show in Fig. 6A, MINDY1 depletion significantly increased ERα ubiquitylation in MCF-7 cells."
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"We observed that MINDY1 reduced ERα ubiquitylation in MCF-7 cells in a dose-dependent manner (Fig. 6C)."
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"Furthermore, MINDY1 reduced the ubiquitylation of ERα induced by the E3 ligase TRIM8 (Fig. 6D) [26]."
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MINDY1 leads to the deubiquitination of endoplasmic reticulum. 1 / 1
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"Specifically, MINDY1 associated with the N-terminal of ERα via its catalytic domain, thus inhibiting K48-specific poly-ubiquitination process on ERα protein."
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