IndraLab

Statements

OTUD6A affects Aurora-A

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OTUD6A activates Aurora-A.

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OTUD6A activates Aurora-A. 5 / 5

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"OTUD6A Promotes Protein Stability and Kinase Activity of Aurora-A."

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eidos

"Therefore , OTUD6A was selected as a DUB that binds to , deubiquitinates , and activates Aurora-A ."

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eidos

"Notably , OTUD6A promotes the protein half-life of Aurora-A and activates Aurora-A by increasing phosphorylation at threonine 288 of Aurora-A ."

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eidos

"Consequently , our data suggest that Aurora-A , a critical mitotic regulator , is deubiquitinated , stabilized , and activated by OTUD6A , which in turn activates PLK1 to drive cells into mitosis ."

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"Notably, OTUD6A promotes the protein half-life of Aurora-A and activates Aurora-A by increasing phosphorylation at threonine 288 of Aurora-A."

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OTUD6A deubiquitinates Aurora-A.

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OTUD6A deubiquitinates Aurora-A. 4 / 4

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"Only OTUD1 and OTUD6A induced the deubiquitination of Aurora-A (XREF_FIG a)."

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"OTUD6A Deubiquitinates Aurora-A."

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"We found that OTUD6A deubiquitinates Aurora-A to stabilize and activate by interacting through the kinase domain of Aurora-A."

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"OTUD6A interacts with Aurora-A through OTU and kinase domains, respectively, and deubiquitinates Aurora-A."

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OTUD6A binds Aurora-A.

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OTUD6A binds Aurora-A. 3 / 3

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"As shown in XREF_FIG b, OTUD6A indeed interacted with Aurora-A."

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"OTUD6A interacts with Aurora-A through OTU and kinase domains, respectively, and deubiquitinates Aurora-A."

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"To confirm the interaction between Aurora-A and OTUD6A, we conducted reverse co-immunoprecipitation by pulling down MYC tagged Aurora-A from the transfected HEK293T cell lysate and subsequently immunoblotted SFB tagged OTUD6A with FLAG antibody."

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OTUD6A affects protein half-life Aurora-A

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OTUD6A activates protein half-life Aurora-A. 2 / 2

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"When normalized following quantitation , the protein half-life of Aurora-A was improved from ~ 17 to ~ 33 h by OTUD6A ( Figure 4a , b ) ."

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eidos

"Notably , OTUD6A promotes the protein half-life of Aurora-A and activates Aurora-A by increasing phosphorylation at threonine 288 of Aurora-A ."

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OTUD6A affects PLK1

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OTUD6A activates PLK1. 2 / 2

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"Consequently, our data suggest that Aurora-A, a critical mitotic regulator, is deubiquitinated, stabilized, and activated by OTUD6A, which in turn activates PLK1 to drive cells into mitosis."

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eidos

"Consequently , our data suggest that Aurora-A , a critical mitotic regulator , is deubiquitinated , stabilized , and activated by OTUD6A , which in turn activates PLK1 to drive cells into mitosis ."

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OTUD6A affects DNM1L

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OTUD6A increases the amount of DNM1L.

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Modified OTUD6A increases the amount of DNM1L. 1 / 1

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"Conversely, overexpression of OTUD6A increases Drp1 levels and its protein half-life and enhances cancer cell growth."

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OTUD6A decreases the amount of DNM1L.

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OTUD6A decreases the amount of DNM1L. 1 / 1

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"Depletion of OTUD6A leads to lower Drp1 levels and suppressed mitochondrial fission and the affected cells are consequently less prone to tumorigenesis."

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OTUD6A affects CKS2

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OTUD6A increases the amount of CKS2.

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OTUD6A increases the amount of CKS2. 1 / 1

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"OTUD6A Promotes CKS2 Gene Expression."

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OTUD6A activates CKS2.

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OTUD6A activates CKS2. 1 / 1

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"We conducted an independent validation and found that CKS2 was significantly upregulated by OTUD6A overexpression (XREF_FIG b)."

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OTUD6A is modified

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OTUD6A is phosphorylated on S71. 1 / 1

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hprd

No evidence text available

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OTUD6A is phosphorylated on S74. 1 / 1

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hprd

No evidence text available

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Valproic acid affects OTUD6A

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Valproic acid methylates OTUD6A. 1 / 1

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ctd

No evidence text available

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Tris(1,3-dichloro-2-propyl)phosphate affects OTUD6A

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Tris(1,3-dichloro-2-propyl)phosphate decreases the amount of OTUD6A. 1 / 1

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ctd

No evidence text available

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Potassium dichromate affects OTUD6A

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Potassium dichromate decreases the amount of OTUD6A. 1 / 1

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ctd

No evidence text available

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Phorbol 13-acetate 12-myristate affects OTUD6A

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Phorbol 13-acetate 12-myristate decreases the amount of OTUD6A. 1 / 1

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ctd

No evidence text available

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Ionomycin affects OTUD6A

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Ionomycin decreases the amount of OTUD6A. 1 / 1

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ctd

No evidence text available

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Hsa-miR-92a-3p affects OTUD6A

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Hsa-miR-92a-3p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-92a-2-5p affects OTUD6A

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Hsa-miR-92a-2-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-6855-5p affects OTUD6A

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Hsa-miR-6855-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-6832-5p affects OTUD6A

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Hsa-miR-6832-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-6742-5p affects OTUD6A

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Hsa-miR-6742-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-6134 affects OTUD6A

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Hsa-miR-6134 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-588 affects OTUD6A

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Hsa-miR-588 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-548s affects OTUD6A

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Hsa-miR-548s decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-5096 affects OTUD6A

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Hsa-miR-5096 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-4781-3p affects OTUD6A

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Hsa-miR-4781-3p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-4732-5p affects OTUD6A

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Hsa-miR-4732-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-4716-5p affects OTUD6A

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Hsa-miR-4716-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-4701-5p affects OTUD6A

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Hsa-miR-4701-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-4435 affects OTUD6A

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Hsa-miR-4435 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-3674 affects OTUD6A

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Hsa-miR-3674 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-3187-3p affects OTUD6A

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Hsa-miR-3187-3p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-3170 affects OTUD6A

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Hsa-miR-3170 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-3149 affects OTUD6A

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Hsa-miR-3149 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-197-3p affects OTUD6A

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Hsa-miR-197-3p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-193b-5p affects OTUD6A

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Hsa-miR-193b-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-129-5p affects OTUD6A

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Hsa-miR-129-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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UBC affects OTUD6A

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UBC binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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TRIM5 affects OTUD6A

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TRIM5 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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TRIM46 affects OTUD6A

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TRIM46 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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TRIM39 affects OTUD6A

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TRIM39 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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RNF2 affects OTUD6A

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RNF2 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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RBCK1 affects OTUD6A

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RBCK1 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects transcription oncogenic cell cycle-regulating

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OTUD6A activates transcription oncogenic cell cycle-regulating. 1 / 1

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"Moreover , OTUD6A induces the transcription of an oncogenic cell cycle-regulating gene , CKS2 ( Cyclin-dependent kinases regulatory subunit 2 ) [ 24 ] ."

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OTUD6A affects protein crucial inducers

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OTUD6A activates protein crucial inducers. 1 / 1

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"However , it has been demonstrated that OTUD6A enhances the protein levels of one of the crucial EMT inducers , Snail [ 22 ] , and promotes colorectal cancer by deubiquitinating and stabilizing DRP1 [ 23 ] ."

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OTUD6A affects protein Snail epithelial-mesenchymal transition inducer tumorigenecity

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OTUD6A activates protein Snail epithelial-mesenchymal transition inducer tumorigenecity. 1 / 1

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"OTUD6A enhances the protein levels of Snail , an EMT ( epithelial-mesenchymal transition ) inducer [ 22 ] , and promotes tumorigenecity by deubiquitinating and stabilizing Drp1 [ 23 ] ."

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OTUD6A affects kinase Aurora-A

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OTUD6A activates kinase Aurora-A. 1 / 1

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"We examined whether OTUD6A promotes the kinase activity of Aurora-A by analyzing phosphorylation at threonine 288 ."

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OTUD6A affects epithelial to mesenchymal transition

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OTUD6A activates epithelial to mesenchymal transition. 1 / 1

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"However, it has been demonstrated that OTUD6A enhances the protein levels of one of the crucial EMT inducers, Snail [XREF_BIBR], and promotes colorectal cancer by deubiquitinating and stabilizing DRP1 [XREF_BIBR]."

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OTUD6A affects enzymatic

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OTUD6A activates enzymatic. 1 / 1

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"Collectively , OTUD6A stabilizes Aurora-A and activates its enzymatic activity ."

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OTUD6A affects deubiquitination Aurora-A

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OTUD6A activates deubiquitination Aurora-A. 1 / 1

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"Only OTUD1 and OTUD6A induced the deubiquitination of Aurora-A ( Figure 2a ) ."

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OTUD6A affects cell population proliferation

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OTUD6A activates cell population proliferation. 1 / 1

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"Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission."

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OTUD6A affects cell growth

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Modified OTUD6A activates cell growth. 1 / 1

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"Conversely, overexpression of OTUD6A increases Drp1 levels and its protein half-life and enhances cancer cell growth."

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OTUD6A affects UBC

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UBC binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects TRIM5

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TRIM5 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects TRIM46

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TRIM46 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects TRIM39

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TRIM39 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects SNAI1

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OTUD6A increases the amount of SNAI1. 1 / 1

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"OTUD6A enhances the protein levels of Snail, an EMT (epithelial-mesenchymal transition) inducer [XREF_BIBR], and promotes tumorigenecity by deubiquitinating and stabilizing Drp1 [XREF_BIBR]."

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OTUD6A affects RNF2

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RNF2 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects RBCK1

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RBCK1 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects Protein Stability Kinase Aurora-A

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OTUD6A activates Protein Stability Kinase Aurora-A. 1 / 1

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"OTUD6A Promotes Protein Stability and Kinase Activity of Aurora-A To determine whether OTUD6A-mediated deubiquitination increases protein stability of Aurora-A , we transfected SFB-tagged OTUD6A into HEK293T cells and treated the cells with cycloheximide at 50 mug / mL for the indicated period ."

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