IndraLab

Statements


OTUD6A affects Aurora-A
| 3 9
OTUD6A activates Aurora-A.
| 3 2
OTUD6A activates Aurora-A. 5 / 5
| 3 2

reach
"OTUD6A Promotes Protein Stability and Kinase Activity of Aurora-A."

eidos
"Therefore , OTUD6A was selected as a DUB that binds to , deubiquitinates , and activates Aurora-A ."

eidos
"Notably , OTUD6A promotes the protein half-life of Aurora-A and activates Aurora-A by increasing phosphorylation at threonine 288 of Aurora-A ."

eidos
"Consequently , our data suggest that Aurora-A , a critical mitotic regulator , is deubiquitinated , stabilized , and activated by OTUD6A , which in turn activates PLK1 to drive cells into mitosis ."

reach
"Notably, OTUD6A promotes the protein half-life of Aurora-A and activates Aurora-A by increasing phosphorylation at threonine 288 of Aurora-A."
OTUD6A deubiquitinates Aurora-A.
| 4
OTUD6A deubiquitinates Aurora-A. 4 / 4
| 4

reach
"Only OTUD1 and OTUD6A induced the deubiquitination of Aurora-A (XREF_FIG a)."

reach
"OTUD6A Deubiquitinates Aurora-A."

reach
"We found that OTUD6A deubiquitinates Aurora-A to stabilize and activate by interacting through the kinase domain of Aurora-A."

reach
"OTUD6A interacts with Aurora-A through OTU and kinase domains, respectively, and deubiquitinates Aurora-A."
OTUD6A binds Aurora-A.
| 3
OTUD6A binds Aurora-A. 3 / 3
| 3

reach
"As shown in XREF_FIG b, OTUD6A indeed interacted with Aurora-A."

reach
"OTUD6A interacts with Aurora-A through OTU and kinase domains, respectively, and deubiquitinates Aurora-A."

reach
"To confirm the interaction between Aurora-A and OTUD6A, we conducted reverse co-immunoprecipitation by pulling down MYC tagged Aurora-A from the transfected HEK293T cell lysate and subsequently immunoblotted SFB tagged OTUD6A with FLAG antibody."
OTUD6A affects protein half-life Aurora-A
| 2
OTUD6A activates protein half-life Aurora-A. 2 / 2
| 2

eidos
"When normalized following quantitation , the protein half-life of Aurora-A was improved from ~ 17 to ~ 33 h by OTUD6A ( Figure 4a , b ) ."

eidos
"Notably , OTUD6A promotes the protein half-life of Aurora-A and activates Aurora-A by increasing phosphorylation at threonine 288 of Aurora-A ."
OTUD6A affects PLK1
| 1 1
OTUD6A activates PLK1. 2 / 2
| 1 1

reach
"Consequently, our data suggest that Aurora-A, a critical mitotic regulator, is deubiquitinated, stabilized, and activated by OTUD6A, which in turn activates PLK1 to drive cells into mitosis."

eidos
"Consequently , our data suggest that Aurora-A , a critical mitotic regulator , is deubiquitinated , stabilized , and activated by OTUD6A , which in turn activates PLK1 to drive cells into mitosis ."
OTUD6A affects DNM1L
| 2
OTUD6A increases the amount of DNM1L.
| 1
Modified OTUD6A increases the amount of DNM1L. 1 / 1
| 1

reach
"Conversely, overexpression of OTUD6A increases Drp1 levels and its protein half-life and enhances cancer cell growth."
OTUD6A decreases the amount of DNM1L.
| 1
OTUD6A decreases the amount of DNM1L. 1 / 1
| 1

reach
"Depletion of OTUD6A leads to lower Drp1 levels and suppressed mitochondrial fission and the affected cells are consequently less prone to tumorigenesis."
OTUD6A affects CKS2
| 2
OTUD6A increases the amount of CKS2.
| 1
OTUD6A increases the amount of CKS2. 1 / 1
| 1

reach
"OTUD6A Promotes CKS2 Gene Expression."
OTUD6A activates CKS2.
| 1
OTUD6A activates CKS2. 1 / 1
| 1

reach
"We conducted an independent validation and found that CKS2 was significantly upregulated by OTUD6A overexpression (XREF_FIG b)."
OTUD6A is modified
2 |
OTUD6A is phosphorylated on S71. 1 / 1
1 |

No evidence text available
OTUD6A is phosphorylated on S74. 1 / 1
1 |

No evidence text available
1 |
1 |

No evidence text available

No evidence text available
Potassium dichromate decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |

No evidence text available
Ionomycin affects OTUD6A
1 |
Ionomycin decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-92a-3p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-92a-2-5p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-6855-5p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-6832-5p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-6742-5p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-6134 decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-588 decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-548s decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-5096 decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-4781-3p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-4732-5p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-4716-5p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-4701-5p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-4435 decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-3674 decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-3187-3p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-3170 decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-3149 decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-197-3p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-193b-5p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Hsa-miR-129-5p decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
UBC affects OTUD6A
1 |
1 |

No evidence text available
TRIM5 affects OTUD6A
1 |
1 |

No evidence text available
TRIM46 affects OTUD6A
1 |
1 |

No evidence text available
TRIM39 affects OTUD6A
1 |
1 |

No evidence text available
RNF2 affects OTUD6A
1 |
1 |

No evidence text available
RBCK1 affects OTUD6A
1 |
1 |

No evidence text available
OTUD6A affects transcription oncogenic cell cycle-regulating
| 1
OTUD6A activates transcription oncogenic cell cycle-regulating. 1 / 1
| 1

eidos
"Moreover , OTUD6A induces the transcription of an oncogenic cell cycle-regulating gene , CKS2 ( Cyclin-dependent kinases regulatory subunit 2 ) [ 24 ] ."
OTUD6A affects protein crucial inducers
| 1
OTUD6A activates protein crucial inducers. 1 / 1
| 1

eidos
"However , it has been demonstrated that OTUD6A enhances the protein levels of one of the crucial EMT inducers , Snail [ 22 ] , and promotes colorectal cancer by deubiquitinating and stabilizing DRP1 [ 23 ] ."
OTUD6A affects protein Snail epithelial-mesenchymal transition inducer tumorigenecity
| 1
OTUD6A activates protein Snail epithelial-mesenchymal transition inducer tumorigenecity. 1 / 1
| 1

eidos
"OTUD6A enhances the protein levels of Snail , an EMT ( epithelial-mesenchymal transition ) inducer [ 22 ] , and promotes tumorigenecity by deubiquitinating and stabilizing Drp1 [ 23 ] ."
OTUD6A affects kinase Aurora-A
| 1
OTUD6A activates kinase Aurora-A. 1 / 1
| 1

eidos
"We examined whether OTUD6A promotes the kinase activity of Aurora-A by analyzing phosphorylation at threonine 288 ."

reach
"However, it has been demonstrated that OTUD6A enhances the protein levels of one of the crucial EMT inducers, Snail [XREF_BIBR], and promotes colorectal cancer by deubiquitinating and stabilizing DRP1 [XREF_BIBR]."
OTUD6A affects enzymatic
| 1
OTUD6A activates enzymatic. 1 / 1
| 1

eidos
"Collectively , OTUD6A stabilizes Aurora-A and activates its enzymatic activity ."
OTUD6A affects deubiquitination Aurora-A
| 1
OTUD6A activates deubiquitination Aurora-A. 1 / 1
| 1

eidos
"Only OTUD1 and OTUD6A induced the deubiquitination of Aurora-A ( Figure 2a ) ."

reach
"Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission."
| 1
Modified OTUD6A activates cell growth. 1 / 1
| 1

reach
"Conversely, overexpression of OTUD6A increases Drp1 levels and its protein half-life and enhances cancer cell growth."
OTUD6A affects UBC
1 |
1 |

No evidence text available
OTUD6A affects TRIM5
1 |
1 |

No evidence text available
OTUD6A affects TRIM46
1 |
1 |

No evidence text available
OTUD6A affects TRIM39
1 |
1 |

No evidence text available
OTUD6A affects SNAI1
| 1
OTUD6A increases the amount of SNAI1. 1 / 1
| 1

reach
"OTUD6A enhances the protein levels of Snail, an EMT (epithelial-mesenchymal transition) inducer [XREF_BIBR], and promotes tumorigenecity by deubiquitinating and stabilizing Drp1 [XREF_BIBR]."
OTUD6A affects RNF2
1 |
1 |

No evidence text available
OTUD6A affects RBCK1
1 |
1 |

No evidence text available
OTUD6A affects Protein Stability Kinase Aurora-A
| 1
OTUD6A activates Protein Stability Kinase Aurora-A. 1 / 1
| 1

eidos
"OTUD6A Promotes Protein Stability and Kinase Activity of Aurora-A To determine whether OTUD6A-mediated deubiquitination increases protein stability of Aurora-A , we transfected SFB-tagged OTUD6A into HEK293T cells and treated the cells with cycloheximide at 50 mug / mL for the indicated period ."
OTUD6A affects GPR21
1 |
1 |

No evidence text available
OTUD6A affects DARS1
1 |
1 |

No evidence text available

eidos
"However , it has been demonstrated that OTUD6A enhances the protein levels of one of the crucial EMT inducers , Snail [ 22 ] , and promotes colorectal cancer by deubiquitinating and stabilizing DRP1 [ 23 ] ."
OTUD6A affects CBLC
1 |
1 |

No evidence text available
OTUD1 affects OTUD6A
| 1
OTUD1 activates OTUD6A. 1 / 1
| 1

reach
"Moreover, OTUD1 was not able to increase the enzymatic activity of Aurora-A as much as OTUD6A."
GPR21 affects OTUD6A
1 |
1 |

No evidence text available
FOXO4 affects OTUD6A
1 |
FOXO4 decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
1 |
Dietary Sucrose increases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
DARS1 affects OTUD6A
1 |
1 |

No evidence text available
Cuprizone affects OTUD6A
1 |
Cuprizone decreases the amount of OTUD6A. 1 / 1
1 |

No evidence text available
CBLC affects OTUD6A
1 |
1 |

No evidence text available