IndraLab

Statements

OTUD6A affects Aurora-A

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OTUD6A activates Aurora-A.

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OTUD6A activates Aurora-A. 5 / 5

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"Notably , OTUD6A promotes the protein half-life of Aurora-A and activates Aurora-A by increasing phosphorylation at threonine 288 of Aurora-A ."

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"OTUD6A Promotes Protein Stability and Kinase Activity of Aurora-A."

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"Therefore , OTUD6A was selected as a DUB that binds to , deubiquitinates , and activates Aurora-A ."

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"Consequently , our data suggest that Aurora-A , a critical mitotic regulator , is deubiquitinated , stabilized , and activated by OTUD6A , which in turn activates PLK1 to drive cells into mitosis ."

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"Notably, OTUD6A promotes the protein half-life of Aurora-A and activates Aurora-A by increasing phosphorylation at threonine 288 of Aurora-A."

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OTUD6A deubiquitinates Aurora-A.

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OTUD6A deubiquitinates Aurora-A. 4 / 4

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"We found that OTUD6A deubiquitinates Aurora-A to stabilize and activate by interacting through the kinase domain of Aurora-A."

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"Only OTUD1 and OTUD6A induced the deubiquitination of Aurora-A (XREF_FIG a)."

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"OTUD6A Deubiquitinates Aurora-A."

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"OTUD6A interacts with Aurora-A through OTU and kinase domains, respectively, and deubiquitinates Aurora-A."

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OTUD6A binds Aurora-A.

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OTUD6A binds Aurora-A. 3 / 3

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"To confirm the interaction between Aurora-A and OTUD6A, we conducted reverse co-immunoprecipitation by pulling down MYC tagged Aurora-A from the transfected HEK293T cell lysate and subsequently immunoblotted SFB tagged OTUD6A with FLAG antibody."

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"As shown in XREF_FIG b, OTUD6A indeed interacted with Aurora-A."

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"OTUD6A interacts with Aurora-A through OTU and kinase domains, respectively, and deubiquitinates Aurora-A."

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OTUD6A affects Carcinogenesis

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OTUD6A inhibits Carcinogenesis.

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OTUD6A inhibits Carcinogenesis. 2 / 2

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"In vivo experiments demonstrated that OTUD6A oligonucleotides markedly suppressed prostate tumorigenesis in Pten PC-/- mice and patient-derived xenograft (PDX) models."

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"Moreover, genetic ablation of OTUD6A efficiently represses prostatic tumorigenesis of both human PrCa cells and the Hi-Myc transgenic PrCa mice, via reversing the metabolic remodeling caused by c-Myc overexpression in PrCa."

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OTUD6A activates Carcinogenesis.

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OTUD6A activates Carcinogenesis. 2 / 2

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"OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR."

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"Correction to: Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc."

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OTUD6A affects NLRP3

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OTUD6A binds NLRP3.

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NLRP3 binds OTUD6A and NACHT domain. 1 / 1

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"Mechanistically, OTUD6A directly bound to NACHT domain of NLRP3 inflammasome and selectively cleaved K48-linked polyubiquitin chains from NLRP3 at K430 and K689 to enhance the stability of NLRP3, leading to increased IL-1β level and inflammation."

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NLRP3 binds OTUD6A and K48. 1 / 1

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OTUD6A deubiquitinates NLRP3.

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OTUD6A deubiquitinates NLRP3. 1 / 1

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"Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3."

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Aurora-A affects OTUD6A

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OTUD6A binds Aurora-A. 3 / 3

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"As shown in XREF_FIG b, OTUD6A indeed interacted with Aurora-A."

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"OTUD6A interacts with Aurora-A through OTU and kinase domains, respectively, and deubiquitinates Aurora-A."

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PPP2 affects OTUD6A

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PPP2 dephosphorylates OTUD6A.

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PPP2 dephosphorylates OTUD6A. 1 / 1

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"Mechanistically, in response to DNA damage, the abundance of OTUD6A was increased; meanwhile, PP2A interacted with OTUD6A and dephosphorylated OTUD6A at sites S70/71/74, which promoted nuclear localization of OTUD6A."

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PPP2 binds OTUD6A.

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PPP2 binds OTUD6A. 1 / 1

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OTUD6A affects protein half-life Aurora-A

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OTUD6A activates protein half-life Aurora-A. 2 / 2

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"Notably , OTUD6A promotes the protein half-life of Aurora-A and activates Aurora-A by increasing phosphorylation at threonine 288 of Aurora-A ."

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"When normalized following quantitation , the protein half-life of Aurora-A was improved from ~ 17 to ~ 33 h by OTUD6A ( Figure 4a , b ) ."

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OTUD6A affects cell population proliferation

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OTUD6A activates cell population proliferation. 2 / 2

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"Moreover, OTUD6A is expressed at high levels in breast cancer, and OTUD6A overexpression promotes cell proliferation, migration and invasion, indicating that dysregulation of OTUD6A expression contributes to genomic instability and is associated with tumor development."

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"Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission."

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OTUD6A affects TOPBP1

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OTUD6A activates TOPBP1. 2 / 2

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"Consistently, knockout of OTUD6A rendered mice hypersensitive to irradiation, shortened survival, and inhibited tumor growth by regulating TopBP1 in xenografted nude mice."

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"Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy."

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OTUD6A affects PLK1

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OTUD6A activates PLK1. 2 / 2

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"Consequently , our data suggest that Aurora-A , a critical mitotic regulator , is deubiquitinated , stabilized , and activated by OTUD6A , which in turn activates PLK1 to drive cells into mitosis ."

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"Consequently, our data suggest that Aurora-A, a critical mitotic regulator, is deubiquitinated, stabilized, and activated by OTUD6A, which in turn activates PLK1 to drive cells into mitosis."

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OTUD6A affects DNM1L

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OTUD6A increases the amount of DNM1L.

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Modified OTUD6A increases the amount of DNM1L. 1 / 1

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"Conversely, overexpression of OTUD6A increases Drp1 levels and its protein half-life and enhances cancer cell growth."

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OTUD6A decreases the amount of DNM1L.

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OTUD6A decreases the amount of DNM1L. 1 / 1

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"Depletion of OTUD6A leads to lower Drp1 levels and suppressed mitochondrial fission and the affected cells are consequently less prone to tumorigenesis."

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OTUD6A affects CKS2

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OTUD6A increases the amount of CKS2.

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OTUD6A increases the amount of CKS2. 1 / 1

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"OTUD6A Promotes CKS2 Gene Expression."

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OTUD6A activates CKS2.

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OTUD6A activates CKS2. 1 / 1

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"We conducted an independent validation and found that CKS2 was significantly upregulated by OTUD6A overexpression (XREF_FIG b)."

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OTUD6A is modified

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OTUD6A is phosphorylated on S71. 1 / 1

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hprd

No evidence text available

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OTUD6A is phosphorylated on S74. 1 / 1

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hprd

No evidence text available

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NLRP3 affects OTUD6A

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NLRP3 binds OTUD6A and NACHT domain. 1 / 1

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NLRP3 binds OTUD6A and K48. 1 / 1

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Valproic acid affects OTUD6A

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Valproic acid methylates OTUD6A. 1 / 1

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ctd

No evidence text available

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Tris(1,3-dichloro-2-propyl)phosphate affects OTUD6A

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Tris(1,3-dichloro-2-propyl)phosphate decreases the amount of OTUD6A. 1 / 1

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ctd

No evidence text available

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Potassium dichromate affects OTUD6A

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Potassium dichromate decreases the amount of OTUD6A. 1 / 1

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ctd

No evidence text available

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Phorbol 13-acetate 12-myristate affects OTUD6A

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Phorbol 13-acetate 12-myristate decreases the amount of OTUD6A. 1 / 1

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ctd

No evidence text available

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Ionomycin affects OTUD6A

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Ionomycin decreases the amount of OTUD6A. 1 / 1

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ctd

No evidence text available

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Hsa-miR-92a-3p affects OTUD6A

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Hsa-miR-92a-3p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-92a-2-5p affects OTUD6A

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Hsa-miR-92a-2-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-6855-5p affects OTUD6A

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Hsa-miR-6855-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-6832-5p affects OTUD6A

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Hsa-miR-6832-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-6742-5p affects OTUD6A

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Hsa-miR-6742-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-6134 affects OTUD6A

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Hsa-miR-6134 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-588 affects OTUD6A

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Hsa-miR-588 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-548s affects OTUD6A

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Hsa-miR-548s decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-5096 affects OTUD6A

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Hsa-miR-5096 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-4781-3p affects OTUD6A

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Hsa-miR-4781-3p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-4732-5p affects OTUD6A

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Hsa-miR-4732-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-4716-5p affects OTUD6A

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Hsa-miR-4716-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-4701-5p affects OTUD6A

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Hsa-miR-4701-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-4435 affects OTUD6A

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Hsa-miR-4435 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-3674 affects OTUD6A

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Hsa-miR-3674 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-3187-3p affects OTUD6A

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Hsa-miR-3187-3p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-3170 affects OTUD6A

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Hsa-miR-3170 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-3149 affects OTUD6A

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Hsa-miR-3149 decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-197-3p affects OTUD6A

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Hsa-miR-197-3p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-193b-5p affects OTUD6A

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Hsa-miR-193b-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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Hsa-miR-129-5p affects OTUD6A

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Hsa-miR-129-5p decreases the amount of OTUD6A. 1 / 1

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biopax:mirtarbase

No evidence text available

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UBC affects OTUD6A

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UBC binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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TRIM5 affects OTUD6A

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TRIM5 binds OTUD6A. 1 / 1

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biogrid

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TRIM46 affects OTUD6A

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TRIM46 binds OTUD6A. 1 / 1

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biogrid

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TRIM39 affects OTUD6A

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TRIM39 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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S70/71/74 affects OTUD6A

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S70/71/74 activates OTUD6A. 1 / 1

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RNF2 affects OTUD6A

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RNF2 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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RBCK1 affects OTUD6A

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RBCK1 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects transcription oncogenic cell cycle-regulating

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OTUD6A activates transcription oncogenic cell cycle-regulating. 1 / 1

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"Moreover , OTUD6A induces the transcription of an oncogenic cell cycle-regulating gene , CKS2 ( Cyclin-dependent kinases regulatory subunit 2 ) [ 24 ] ."

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OTUD6A affects protein crucial inducers

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OTUD6A activates protein crucial inducers. 1 / 1

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"However , it has been demonstrated that OTUD6A enhances the protein levels of one of the crucial EMT inducers , Snail [ 22 ] , and promotes colorectal cancer by deubiquitinating and stabilizing DRP1 [ 23 ] ."

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OTUD6A affects protein Snail epithelial-mesenchymal transition inducer tumorigenecity

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OTUD6A activates protein Snail epithelial-mesenchymal transition inducer tumorigenecity. 1 / 1

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"OTUD6A enhances the protein levels of Snail , an EMT ( epithelial-mesenchymal transition ) inducer [ 22 ] , and promotes tumorigenecity by deubiquitinating and stabilizing Drp1 [ 23 ] ."

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OTUD6A affects prostatic tumorigenesis

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OTUD6A activates prostatic tumorigenesis. 1 / 1

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"These results indicate that OTUD6A is a physiological DUB for c-Myc in PrCa setting and specifically promotes prostatic tumorigenesis through stabilizing c-Myc oncoprotein , suggesting that OTUD6A could be a unique therapeutic target for Myc-driven PrCa ."

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OTUD6A affects prostate tumorigenesis

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OTUD6A activates prostate tumorigenesis. 1 / 1

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"OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR ."

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OTUD6A affects kinase Aurora-A

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OTUD6A activates kinase Aurora-A. 1 / 1

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"We examined whether OTUD6A promotes the kinase activity of Aurora-A by analyzing phosphorylation at threonine 288 ."

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OTUD6A affects epithelial to mesenchymal transition

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OTUD6A activates epithelial to mesenchymal transition. 1 / 1

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"However, it has been demonstrated that OTUD6A enhances the protein levels of one of the crucial EMT inducers, Snail [XREF_BIBR], and promotes colorectal cancer by deubiquitinating and stabilizing DRP1 [XREF_BIBR]."

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OTUD6A affects enzymatic

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OTUD6A activates enzymatic. 1 / 1

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"Collectively , OTUD6A stabilizes Aurora-A and activates its enzymatic activity ."

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OTUD6A affects dextran sulfate

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OTUD6A activates dextran sulfate. 1 / 1

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"Our data show that OTUD6A deficiency attenuated DSS or TNBS-induced colitis , as well as AOM / DSS-induced colitis-related colon cancer in vivo ."

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OTUD6A affects deubiquitination Aurora-A

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OTUD6A activates deubiquitination Aurora-A. 1 / 1

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"Only OTUD1 and OTUD6A induced the deubiquitination of Aurora-A ( Figure 2a ) ."

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OTUD6A affects cell growth

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Modified OTUD6A activates cell growth. 1 / 1

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"Conversely, overexpression of OTUD6A increases Drp1 levels and its protein half-life and enhances cancer cell growth."

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OTUD6A affects cell cycle

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OTUD6A activates cell cycle. 1 / 1

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"OTUD6A depletion impaired CHK1 S345 phosphorylation and blocked cell cycle progression under DNA replication stress."

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OTUD6A affects UBC

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UBC binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects TRIM5

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TRIM5 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects TRIM46

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TRIM46 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects TRIM39

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TRIM39 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects SNAI1

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OTUD6A increases the amount of SNAI1. 1 / 1

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"OTUD6A enhances the protein levels of Snail, an EMT (epithelial-mesenchymal transition) inducer [XREF_BIBR], and promotes tumorigenecity by deubiquitinating and stabilizing Drp1 [XREF_BIBR]."

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OTUD6A affects RNF2

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RNF2 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects RBCK1

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RBCK1 binds OTUD6A. 1 / 1

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biogrid

No evidence text available

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OTUD6A affects Protein Stability Kinase Aurora-A

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OTUD6A activates Protein Stability Kinase Aurora-A. 1 / 1

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"OTUD6A Promotes Protein Stability and Kinase Activity of Aurora-A To determine whether OTUD6A-mediated deubiquitination increases protein stability of Aurora-A , we transfected SFB-tagged OTUD6A into HEK293T cells and treated the cells with cycloheximide at 50 mug / mL for the indicated period ."

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OTUD6A affects PPP2

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PPP2 binds OTUD6A. 1 / 1

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OTUD6A affects Neoplasms

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OTUD6A activates Neoplasms. 1 / 1

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"Consistently, knockout of OTUD6A rendered mice hypersensitive to irradiation, shortened survival, and inhibited tumor growth by regulating TopBP1 in xenografted nude mice."

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OTUD6A affects NACHT domain

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NLRP3 binds OTUD6A and NACHT domain. 1 / 1

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OTUD6A affects Mice

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OTUD6A inhibits Mice. 1 / 1

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OTUD6A affects K48

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NLRP3 binds OTUD6A and K48. 1 / 1

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OTUD6A affects Genomic Instability

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OTUD6A inhibits Genomic Instability. 1 / 1

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"Moreover , OTUD6A is expressed at high levels in breast cancer , and OTUD6A overexpression promotes cell proliferation , migration and invasion , indicating that dysregulation of OTUD6A expression contributes to genomic instability and is associated with tumor development ."

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