IndraLab

Statements

USP7 affects CDKN1A
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USP7 increases the amount of CDKN1A.
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Modified USP7 increases the amount of CDKN1A. 1 / 1
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"Consistent with our in vitro observations, we found that overexpression of catalytically inactive USP7 in cells promotes p53 binding to its target sequences and p21 expression, without increasing the levels of p53 protein."
20885946
USP7 increases the amount of CDKN1A. 1 / 1
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"Besides, protein expression of p53 and p21 was dramatically downregulated by either GMPS or USP7 knockdown in MCF-7 and DU4475 cells (Fig. 4f, g)."
33742136
USP7 activates CDKN1A.
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USP7 activates CDKN1A. 2 / 2
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"Consistent with the ChIP results, coexpression of WT USP7 or C223S led to induction of p21 (lanes 3 and 4)."
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"Next we tested whether USP7 enhanced p53 function by examining the induction of p21 in H1299 cells after transfection of a p53 expressing plasmid alone or in combination with a plasmid expressing either WT USP7 or a USP7 mutant (XREF_FIG)."
20885946
USP7 decreases the amount of CDKN1A.
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USP7 decreases the amount of CDKN1A. 1 / 1
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"HCT116 USP7 -/- cells grow extremely slowly because USP7 knockout leads to constitutively high level of p53 and p21."
25435364
USP7 binds CDKN1A.
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TP53 binds USP7, CDKN1A, and MDM2. 1 / 1
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"In addition to the altered levels of HDM2, p53 and p21 associated with its use, P22077 treatment also caused reduced levels of DNA damage proteins DDB1, RBX1, DCAF7 and DCAF11, all of which are subunits of E3 ligases, indicating a previously unknown functional link between USP7 and enzymes involved in DNA repair [ xref ]."
23822887
CDKN1A affects USP7
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CDKN1A decreases the amount of USP7.
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CDKN1A decreases the amount of USP7. 1 / 1
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"Furthermore, p21 and bax protein expression was significantly lower in tumours with either mutant p53 or reduced HAUSP expression than in tumours with both wild-type p53 and positive HAUSP expression (p = 0.0440 and p = 0.0046, respectively)."
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CDKN1A binds USP7.
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TP53 binds USP7, CDKN1A, and MDM2. 1 / 1
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sparser
"In addition to the altered levels of HDM2, p53 and p21 associated with its use, P22077 treatment also caused reduced levels of DNA damage proteins DDB1, RBX1, DCAF7 and DCAF11, all of which are subunits of E3 ligases, indicating a previously unknown functional link between USP7 and enzymes involved in DNA repair [ xref ]."
23822887