IndraLab

Statements

USP18 affects IFNAR1
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USP18 inhibits IFNAR1.
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USP18 inhibits IFNAR1. 6 / 6
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"Lacking of USP18 leads to an increase signaling of IFN-I, IFN-III, TNF-α and high levels of conjugated ISG15Figure 3: Role of USP18-dependent enforced viral replication in activation of the adaptive immune system and onset of diabetes mellitus type I. (a) USP18 inhibits IFNAR signaling, which leads to enforced viral replication in CD169+ macrophages."
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"For example, USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169+ macrophages displayed a lower type I IFN sensitivity upon viral infection [38], [57]."
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"For example, USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169 macrophages displayed a lower type I IFN sensitivity upon viral infection [38], [57].4 Strategies to control innate immune activation upon conventional and self-amplifying mRNA delivery."
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"For example, USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169 + macrophages displayed a lower type I IFN sensitivity upon viral infection [38, 57] .4."
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"For example , USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169 + macrophages displayed a lower type I IFN sensitivity upon viral infection [ 38 ] , [ 57 ] ."
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"Th17 cells are widely Figure 3 Role of USP18-dependent enforced viral replication in activation of the adaptive immune system and onset of diabetes mellitus type I. (a) USP18 inhibits IFNAR signaling, which leads to enforced viral replication in CD169 + macrophages."
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USP18 binds IFNAR1.
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USP18 binds IFNAR1. 2 / 2
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"Their study showed that USP18 does not interact with IFNAR1, but with Box1-Box2 region of IFNAR2 to disrupt its interaction with JAK to inhibit JAK’s tyrosine kinase activity in a DUB activity independent manner [ xref ]."
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"Their study showed that USP18 does not interact with IFNAR1, but with Box1-Box2 region of IFNAR2 to disrupt its interaction with JAK to inhibit JAK’s tyrosine kinase activity in a DUB activity independent manner [44]."
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IFNAR1 binds USP18. 1 / 1
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"They further demonstrated that white matter microglia from mice with a different point mutation disrupting the interaction between USP18 and IFNAR showed prolonged STAT1 activation mirroring the interferon signaling findings in the USP18 KO mice [XREF_BIBR]."
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USP18 binds IFNAR1 and JAK1. 1 / 1
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"Usp18 (UBP43) binds to the Jak1 binding site of the type I interferon receptor and inhibits its phosphorylation xref ."
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USP18 binds IFNAR1 and IFNGR1. 1 / 1
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"Furthermore, Usp18 functions in the type I IFN pathway by down-regulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway independently of its isopeptidase activity through an interaction between Usp18 and the IFNAR2 subunit of the type I IFN receptor complex, while neither IFNAR1 nor IFNGR1 (type II IFN) receptor subunits were able to interact with Usp18 ( xref )."
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USP18 activates IFNAR1.
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USP18 activates IFNAR1. 1 / 1
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"Thus, although CD169+ macrophages in both spleen and LN preferentially allow VSV replication, whether Usp18 mediates downmodulation of IFNAR signaling in LN SCS macrophages needs to be examined to complete the circuit."
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IFNAR1 affects USP18
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IFNAR1 binds USP18.
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USP18 binds IFNAR1. 2 / 2
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"Their study showed that USP18 does not interact with IFNAR1, but with Box1-Box2 region of IFNAR2 to disrupt its interaction with JAK to inhibit JAK’s tyrosine kinase activity in a DUB activity independent manner [ xref ]."
31208841
sparser
"Their study showed that USP18 does not interact with IFNAR1, but with Box1-Box2 region of IFNAR2 to disrupt its interaction with JAK to inhibit JAK’s tyrosine kinase activity in a DUB activity independent manner [44]."
31208841
IFNAR1 binds USP18. 1 / 1
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reach
"They further demonstrated that white matter microglia from mice with a different point mutation disrupting the interaction between USP18 and IFNAR showed prolonged STAT1 activation mirroring the interferon signaling findings in the USP18 KO mice [XREF_BIBR]."
28540600
USP18 binds IFNAR1 and JAK1. 1 / 1
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sparser
"Usp18 (UBP43) binds to the Jak1 binding site of the type I interferon receptor and inhibits its phosphorylation xref ."
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USP18 binds IFNAR1 and IFNGR1. 1 / 1
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sparser
"Furthermore, Usp18 functions in the type I IFN pathway by down-regulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway independently of its isopeptidase activity through an interaction between Usp18 and the IFNAR2 subunit of the type I IFN receptor complex, while neither IFNAR1 nor IFNGR1 (type II IFN) receptor subunits were able to interact with Usp18 ( xref )."
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IFNAR1 increases the amount of USP18.
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IFNAR1 increases the amount of USP18. 1 / 1
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"Puromycin resistant clones were screened by PCR andF I G U R E 3 IFNAR blocking inhibits HIV-1 replication and blocks HIV-1-induced USP18 expression in MDMs."
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