IndraLab

Statements

INO80 affects UCHL5
4 | 11 17
INO80 binds UCHL5.
4 | 6 17
UCHL5 binds INO80. 10 / 25
4 | 5 16
sparser
"Interestingly, UCH37 also associates in the nucleus with the human Ino80 chromatin-remodeling complex, where it is held in an inactive state compared to the free enzyme( xref )."
23617878
biogrid
No evidence text available
28514442
sparser
"Uch37 is bound to hINO80 via its C-terminal tail and the N-terminal domain of NFRKB."
18922472
biogrid
No evidence text available
21303910
sparser
"Further studies have suggested that UCH37 is associated with the human Ino80 chromatin-remodeling complex (hINO80) in the nucleus and can be activated via transient association of 19S regulatory parti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23220010
reach
"Our dissection of interactions between hINO80 and Uch37 shows that one polypeptide, NFRKB, has elements that can inhibit and activate deubiquitinating activity."
18922472
reach
"In contrast, INO80 associated Uch37 or Uch37 in complex with the NFRKB 1-465 fragment is either inhibited (as assessed by UbVS reactivity) or held in a relatively inactive state similar to that of free Uch37 (as assessed by its ability to hydrolyze UbAMC)."
18922472
reach
"Considering that INO80 functions in transcription and DNA repair through chromatin remodeling [65], histones and transcription factors are among likely candidates for substrates of INO80 bound Uch37."
28988953
sparser
"The transient association of the INO80 complex with UCH37 regulates the deubiquitylating activity of this subunit."
19424290
biogrid
No evidence text available
18922472
UCHL5 binds INO80 and ULD domain. 1 / 1
| 1
reach
"Both RPN13 DEU and INO80 DEU primarily bind the C-terminal ULD domain of UCH-L5, but are positioned radically differently relative to the UCH-L5 CD, which itself hardly changes conformation among all UCH-L5 structures."
25702870
Proteasome binds UCHL5 and INO80. 1 / 1
| 1
sparser
"UCHL5 is associated with both the proteasome and the INO80 chromatin remodeling complex, and functions in both contexts [ xref ]."
31703099
INO80 activates UCHL5.
| 4
INO80 activates UCHL5. 4 / 4
| 4
reach
"A possibility is that INO80 controls UCH-L5 in a temporal manner, where in some circumstances UCH-L5 is inhibited while under other circumstances post-translational modifications (PTMs) and/or conformational changes release the inhibition and activate UCH-L5, allowing for additional layers of regulation."
25702870
reach
"Curiously, INO80 associated UCH37 can be activated by transient incubation with either RPN13 or 26S proteasome lacking UCH37, without UCH37 dissociating from the INO80 complex."
25702872
reach
"In the nucleus, UCHL5 is also associated with human Ino80 chromatin remodeling complex and kept in inactive state, and then activated by transient interaction of the Ino80 complex with proteasome, suggesting that it may cooperate to regulate transcription or DNA repair XREF_BIBR."
23285140
reach
"Intriguingly, Uch37 is held in an inactive state in the INO80 complex but, at least in vitro, can be activated by transient interaction of the INO80 complex with proteasomes [26]."
19062292
INO80 inhibits UCHL5.
| 1
INO80 inhibits UCHL5. 1 / 1
| 1
reach
"The essential cysteine protease UCH-L5 is activated by proteasome ubiquitin receptor RPN13 (ADRM1) or inhibited by chromatin remodeling complex component INO80 (NFRKB) [XREF_BIBR]."
29371935
UCHL5 affects INO80
4 | 8 17
UCHL5 binds INO80.
4 | 6 17
UCHL5 binds INO80. 10 / 25
4 | 5 16
sparser
"Interestingly, UCH37 also associates in the nucleus with the human Ino80 chromatin-remodeling complex, where it is held in an inactive state compared to the free enzyme( xref )."
23617878
biogrid
No evidence text available
28514442
sparser
"Uch37 is bound to hINO80 via its C-terminal tail and the N-terminal domain of NFRKB."
18922472
biogrid
No evidence text available
21303910
sparser
"Further studies have suggested that UCH37 is associated with the human Ino80 chromatin-remodeling complex (hINO80) in the nucleus and can be activated via transient association of 19S regulatory parti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23220010
reach
"Our dissection of interactions between hINO80 and Uch37 shows that one polypeptide, NFRKB, has elements that can inhibit and activate deubiquitinating activity."
18922472
reach
"In contrast, INO80 associated Uch37 or Uch37 in complex with the NFRKB 1-465 fragment is either inhibited (as assessed by UbVS reactivity) or held in a relatively inactive state similar to that of free Uch37 (as assessed by its ability to hydrolyze UbAMC)."
18922472
reach
"Considering that INO80 functions in transcription and DNA repair through chromatin remodeling [65], histones and transcription factors are among likely candidates for substrates of INO80 bound Uch37."
28988953
sparser
"The transient association of the INO80 complex with UCH37 regulates the deubiquitylating activity of this subunit."
19424290
biogrid
No evidence text available
18922472
UCHL5 binds INO80 and ULD domain. 1 / 1
| 1
reach
"Both RPN13 DEU and INO80 DEU primarily bind the C-terminal ULD domain of UCH-L5, but are positioned radically differently relative to the UCH-L5 CD, which itself hardly changes conformation among all UCH-L5 structures."
25702870
Proteasome binds UCHL5 and INO80. 1 / 1
| 1
sparser
"UCHL5 is associated with both the proteasome and the INO80 chromatin remodeling complex, and functions in both contexts [ xref ]."
31703099
UCHL5 deubiquitinates INO80.
| 1
UCHL5 deubiquitinates INO80. 1 / 1
| 1
reach
"UCHL5 is also required for BLM/EXO1 dependent end resection through de-ubiquitinating the INO80 subunit NFRKB, although the function of this subunit in regulating end resection is not currently understood [37]."
31769469
UCHL5 activates INO80.
| 1
UCHL5 activates INO80. 1 / 1
| 1
reach
"And finally, what genes are targeted by Uch37 containing INO80?"
18922460