IndraLab

"As shown in XREF_FIG C and 1D, SENP1, SENP2, SENP6, andSENP7, as well as USPL1, efficiently promoted global deconjugation of SUMO1 and SUMO2 from target substrates."

28903035

Bisphenol A increases the amount of USPL1.

4 |

Bisphenol A increases the amount of USPL1. 4 / 4

4 |

➶

ctd

No evidence text available

30816183

➶

ctd

No evidence text available

25181051

➶

ctd

No evidence text available

33221593

➶

ctd

No evidence text available

28628672

Bisphenol A methylates USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

30906313

USPL1 affects LEC

| 5

USPL1 binds LEC. 5 / 5

| 5

➶

sparser

"USPL1 also interacts with ICE1, ELL, and EAF1 in PPID data, suggesting there is a physical interaction between USPL1 and the LEC."

35737447

➶

sparser

"USPL1 interacts with LEC components involved in RNAPII-mediated snRNA transcription."

24413172

➶

sparser

"To confirm the interaction of USPL1 with members of the LEC, we first used transient transfection of FLAG–ELL and HA–USPL1."

24413172

➶

sparser

"Our findings, together with other data ( xref ), indicate an association of USPL1 with components of the LEC."

24413172

➶

sparser

"Using a combination of fluorescence microscopy, molecular biology and proteomic approaches, we demonstrate that USPL1 interacts with components of the RNAPII-associated LEC and is associated with the U1 and U2 snRNA gene loci."

24413172

USPL1 affects ICE1

3 | 1

USPL1 binds ICE1. 3 / 3

3 |

➶

biogrid

No evidence text available

24413172

➶

biogrid

No evidence text available

19615732

➶

biogrid

No evidence text available

24413172

USPL1 binds ICE1 and ELL. 1 / 1

| 1

➶

reach

"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."

22195968

USPL1 affects ELL

3 | 1

USPL1 binds ELL. 3 / 3

3 |

➶

biogrid

No evidence text available

24413172

➶

biogrid

No evidence text available

19615732

➶

biogrid

No evidence text available

24413172

USPL1 binds ICE1 and ELL. 1 / 1

| 1

➶

reach

"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."

22195968

ICE1 affects USPL1

3 | 1

USPL1 binds ICE1. 3 / 3

3 |

➶

biogrid

No evidence text available

24413172

➶

biogrid

No evidence text available

19615732

➶

biogrid

No evidence text available

24413172

USPL1 binds ICE1 and ELL. 1 / 1

| 1

➶

reach

"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."

22195968

ELL affects USPL1

3 | 1

USPL1 binds ELL. 3 / 3

3 |

➶

biogrid

No evidence text available

24413172

➶

biogrid

No evidence text available

19615732

➶

biogrid

No evidence text available

24413172

USPL1 binds ICE1 and ELL. 1 / 1

| 1

➶

reach

"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."

22195968

COIL affects USPL1

2 | 1 1

COIL binds USPL1.

2 | 1

USPL1 binds COIL. 2 / 2

2 |

➶

biogrid

No evidence text available

22878415

➶

biogrid

No evidence text available

24413172

COIL binds USPL1 and foci. 1 / 1

| 1

➶

sparser

"Upon knockdown of coilin, USPL1 still formed nuclear foci, similar to SMN ( xref , arrows in middle panel)."

24413172

COIL increases the amount of USPL1.

| 1

COIL increases the amount of USPL1. 1 / 1

| 1

➶

reach

"The overexpression of COIL genes considerably elevated the expression of FBL, ATXN1, WRAP53, and USPL1 genes compared with the control group, as was the expression of SMN, NOLC1, CBS, and KCNG1 genes."

38397224

Pirinixic acid affects USPL1

3 |

Pirinixic acid increases the amount of USPL1. 3 / 3

3 |

➶

ctd

No evidence text available

18301758

➶

ctd

No evidence text available

23811191

➶

ctd

No evidence text available

21318169

USPL1 affects SUMO2

3 |

SUMO2 binds USPL1. 3 / 3

3 |

➶

biogrid

No evidence text available

21988832

➶

biogrid

No evidence text available

22878415

➶

biogrid

No evidence text available

22878415

USPL1 affects SUMO1

2 | 1

USPL1 binds SUMO1.

2 |

SUMO1 binds USPL1. 2 / 2

2 |

➶

biogrid

No evidence text available

22878415

➶

biogrid

No evidence text available

22878415

USPL1 activates SUMO1.

| 1

USPL1 activates SUMO1. 1 / 1

| 1

➶

reach

"As shown in XREF_FIG C and 1D, SENP1, SENP2, SENP6, andSENP7, as well as USPL1, efficiently promoted global deconjugation of SUMO1 and SUMO2 from target substrates."

28903035

USPL1 affects COIL

2 | 1

USPL1 binds COIL. 2 / 2

2 |

➶

biogrid

No evidence text available

22878415

➶

biogrid

No evidence text available

24413172

COIL binds USPL1 and foci. 1 / 1

| 1

➶

sparser

"Upon knockdown of coilin, USPL1 still formed nuclear foci, similar to SMN ( xref , arrows in middle panel)."

24413172

SUMO2 affects USPL1

3 |

SUMO2 binds USPL1. 3 / 3

3 |

➶

biogrid

No evidence text available

21988832

➶

biogrid

No evidence text available

22878415

➶

biogrid

No evidence text available

22878415

CCL16 affects USPL1

| 3

CCL16 binds USPL1.

| 2

USPL1 binds CCL16. 2 / 2

| 2

➶

reach

"The strongest DepMap co-dependent genes for USPL1 across tumor types were members of the Little Elongation Complex (LEC), which is involved in transcription of spliceosomal machinery (Hutten et al., 2014) suggestive of an association between USPL1 and the LEC (Figure 3b)."

35737447

➶

reach

"USPL1 also interacts with ICE1, ELL, and EAF1 in PPID data, suggesting there is a physical interaction between USPL1 and the LEC."

35737447

CCL16 activates USPL1.

| 1

CCL16 activates USPL1. 1 / 1

| 1

➶

reach

"The high degree of similarity between the USPL1 and ICE1 knockouts is consistent with the DepMap prediction that USPL1 activity is mediated largely by the LEC."

35737447

Valproic acid affects USPL1

2 |

Valproic acid decreases the amount of USPL1. 2 / 2

2 |

➶

ctd

No evidence text available

27188386

➶

ctd

No evidence text available

23179753

Thioacetamide affects USPL1

2 |

Thioacetamide increases the amount of USPL1. 2 / 2

2 |

➶

ctd

No evidence text available

23411599

➶

ctd

No evidence text available

34492290

Paracetamol affects USPL1

2 |

Paracetamol increases the amount of USPL1.

1 |

Paracetamol increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

21420995

Paracetamol decreases the amount of USPL1.

1 |

Paracetamol decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

33387578

Formaldehyde affects USPL1

2 |

Formaldehyde increases the amount of USPL1.

1 |

Formaldehyde increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Formaldehyde decreases the amount of USPL1.

1 |

Formaldehyde decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

20655997

Folic acid affects USPL1

2 |

Folic acid demethylates USPL1.

1 |

Folic acid demethylates USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

20938992

Folic acid decreases the amount of USPL1.

1 |

Folic acid decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

22206623

Cyclosporin A affects USPL1

2 |

Cyclosporin A increases the amount of USPL1. 2 / 2

2 |

➶

ctd

No evidence text available

25562108

➶

ctd

No evidence text available

20106945

Cadmium dichloride affects USPL1

2 |

Cadmium dichloride methylates USPL1.

1 |

Cadmium dichloride methylates USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

22457795

Cadmium dichloride increases the amount of USPL1.

1 |

Cadmium dichloride increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

19010381

Aflatoxin B1 affects USPL1

2 |

Aflatoxin B1 increases the amount of USPL1. 2 / 2

2 |

➶

ctd

No evidence text available

19770486

➶

ctd

No evidence text available

27153756

USPL1 affects RANGAP1

2 |

USPL1 binds RANGAP1. 2 / 2

2 |

➶

biogrid

No evidence text available

37712884

➶

biogrid

No evidence text available

22878415

USPL1 affects EAF1

2 |

EAF1 binds USPL1. 2 / 2

2 |

➶

biogrid

No evidence text available

28514442

➶

biogrid

No evidence text available

33961781

USPL1 affects CCL16

| 2

USPL1 binds CCL16. 2 / 2

| 2

➶

reach

35737447

➶

reach

"USPL1 also interacts with ICE1, ELL, and EAF1 in PPID data, suggesting there is a physical interaction between USPL1 and the LEC."

35737447

SUMO1 affects USPL1

2 |

SUMO1 binds USPL1. 2 / 2

2 |

➶

biogrid

No evidence text available

22878415

➶

biogrid

No evidence text available

22878415

RANGAP1 affects USPL1

2 |

USPL1 binds RANGAP1. 2 / 2

2 |

➶

biogrid

No evidence text available

37712884

➶

biogrid

No evidence text available

22878415

Polystyrenes affects USPL1

2 |

Polystyrenes increases the amount of USPL1.

1 |

Polystyrenes increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

36167205

Polystyrenes decreases the amount of USPL1.

1 |

Polystyrenes decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

36167205

PITX2 affects USPL1

2 |

PITX2 decreases the amount of USPL1. 2 / 2

2 |

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

Microplastics affects USPL1

2 |

Microplastics increases the amount of USPL1.

1 |

Microplastics increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

36167205

Microplastics decreases the amount of USPL1.

1 |

Microplastics decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

36167205

EAF1 affects USPL1

2 |

EAF1 binds USPL1. 2 / 2

2 |

➶

biogrid

No evidence text available

28514442

➶

biogrid

No evidence text available

33961781

2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido(4,3-d)pyrimidin-5(6H)-one affects USPL1

2 |

2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido(4,3-d)pyrimidin-5(6H)-one increases the amount of USPL1.

1 |

2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido(4,3-d)pyrimidin-5(6H)-one increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

34170685

2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido(4,3-d)pyrimidin-5(6H)-one activates USPL1.

1 |

2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido(4,3-d)pyrimidin-5(6H)-one activates USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

34170685

Zinc atom affects USPL1

1 |

Zinc atom increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

18593933

Trovafloxacin affects USPL1

1 |

Trovafloxacin increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

35537566

Triptonide affects USPL1

1 |

Triptonide increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

33045310

Titanium dioxide affects USPL1

1 |

Titanium dioxide demethylates USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

35295148

Tetrachloromethane affects USPL1

1 |

Tetrachloromethane increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

31150632

Sunitinib affects USPL1

1 |

Sunitinib increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

31533062

Sorafenib affects USPL1

1 |

Sorafenib decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

39786591

Sodium dichromate affects USPL1

1 |

Sodium dichromate increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

25993096

Sodium arsenite affects USPL1

1 |

Sodium arsenite increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

39836092

SnRNA gene loci affects USPL1

| 1

USPL1 binds snRNA gene loci. 1 / 1

| 1

➶

reach

"Therefore, we decided to investigate whether USPL1 itself could be found associated with snRNA gene loci."

24413172

Smo-1 affects USPL1

| 1

Smo-1 binds USPL1. 1 / 1

| 1

➶

reach

"We therefore examined the interaction of SUMO and USPL1 in more detail.A curated sequence alignment of USPL1 sequences of 183 organisms suggests that recognition of SUMO by USPL1 is based on a highly conserved patch in the finger subdomain, while other surface areas, with the exception of the surroundings of the catalytic center, are much more variable (Figure 3D)."

37712884

Silver(0) affects USPL1

1 |

Silver(0) increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

26014281

Schizandrin B affects USPL1

1 |

Schizandrin B decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

31150632

Resveratrol affects USPL1

1 |

Resveratrol increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

23557933

Response to heat affects USPL1

1 |

Response to heat increases the amount of USPL1. 1 / 1

1 |

➶

bel

"The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)."

11960976

Perfluorooctane-1-sulfonic acid affects USPL1

1 |

Perfluorooctane-1-sulfonic acid decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

36331819

Pentachlorophenol affects USPL1

1 |

Pentachlorophenol decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

24642059

Niclosamide affects USPL1

1 |

Niclosamide increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

31398420

Mitotic G2 phase affects USPL1

1 |

Mitotic G2 phase increases the amount of USPL1. 1 / 1

1 |

➶

bel

"Table I Genes with G2/M-specific and DNA damage-responsive expression: The relative increase in expression during G2 (as compared with S phase, i.e. at 7 h after release when compared with 1 h after release) is indicated in the third and fourth columns, and the average of these two independent analyses are in boldface type in the fifth column. "

11483598

Methyltestosterone affects USPL1

1 |

Methyltestosterone increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

29191790

Methylisothiazolinone affects USPL1

1 |

Methylisothiazolinone increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

31629900

Methyl methanesulfonate affects USPL1

1 |

Methyl methanesulfonate increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Methamphetamine affects USPL1

1 |

Methamphetamine increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

19564919

Mercury(0) affects USPL1

1 |

Mercury(0) increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

16823088

Mercury dichloride affects USPL1

1 |

Mercury dichloride increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

16507785

Manganese(II) chloride affects USPL1

1 |

Manganese(II) chloride increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

39836092

Manganese atom affects USPL1

1 |

Manganese atom increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

39836092

Lead diacetate affects USPL1

1 |

Lead diacetate decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

21829687

Jinfukang affects USPL1

1 |

Jinfukang decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

27392435

Indometacin affects USPL1

1 |

Indometacin increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Indium oxide affects USPL1

1 |

Indium oxide increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

39516272

Hsa-miR-324-5p affects USPL1

1 |

Hsa-miR-324-5p decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

Foci affects USPL1

| 1

COIL binds USPL1 and foci. 1 / 1

| 1

➶

sparser

"Upon knockdown of coilin, USPL1 still formed nuclear foci, similar to SMN ( xref , arrows in middle panel)."

24413172

Fenofibrate affects USPL1

1 |

Fenofibrate increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

21318169

Elesclomol affects USPL1

1 |

Elesclomol increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

18723479

Elemental selenium affects USPL1

1 |

Elemental selenium decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

19244175

Doxorubicin affects USPL1

1 |

Doxorubicin decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

29803840

Disulfiram affects USPL1

1 |

Disulfiram decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

24690739

Dicrotophos affects USPL1

1 |

Dicrotophos decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

28302478

Dexamethasone affects USPL1

1 |

Dexamethasone increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Deltamethrin affects USPL1

1 |

Deltamethrin increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

37019170

Crocidolite asbestos affects USPL1

1 |

Crocidolite asbestos decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

29279043

Copper(II) sulfate affects USPL1

1 |

Copper(II) sulfate increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

19549813

Copper atom affects USPL1

1 |

Copper atom decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

24690739

Choline affects USPL1

1 |

Choline demethylates USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

20938992

Bis(2-ethylhexyl) phthalate affects USPL1

1 |

Bis(2-ethylhexyl) phthalate decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

21318169

Arsenic atom affects USPL1

1 |

Arsenic atom increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

39836092

Aristolochic acid A affects USPL1

1 |

Aristolochic acid A decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

33212167

ZBED4 affects USPL1

1 |

ZBED4 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

35575683

Vitamin E affects USPL1

1 |

Vitamin E decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

19244175

Vehicle Emissions affects USPL1

1 |

Vehicle Emissions methylates USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

25560391

USPL1 affects snRNA gene loci

| 1

USPL1 binds snRNA gene loci. 1 / 1

| 1

➶

reach

"Therefore, we decided to investigate whether USPL1 itself could be found associated with snRNA gene loci."

24413172

USPL1 affects smo-1

| 1

Smo-1 binds USPL1. 1 / 1

| 1

➶

reach

37712884

USPL1 affects localization

| 1

USPL1 inhibits localization. 1 / 1

| 1

➶

reach

"Consistently, the levels of SUMOylated mCherry–FLAG-INTS11 WT decreased by overexpressing GFP–USPL1 or GFP–SENP6 (Supplementary Figure S7E), increasing the INTS11 cytoplasmatic localization (Figure 7A, B)."

36454007

USPL1 affects gus

| 1

USPL1 increases the amount of gus. 1 / 1

| 1

➶

reach

"AtUSPL1 expression was also assayed by tracking GUS expression produced by the pAtUSPL1 : : GUS transgene."

25333723

USPL1 affects foci

| 1

COIL binds USPL1 and foci. 1 / 1

| 1

➶

sparser

"Upon knockdown of coilin, USPL1 still formed nuclear foci, similar to SMN ( xref , arrows in middle panel)."

24413172

USPL1 affects cellular component biogenesis

| 1

USPL1 activates cellular component biogenesis. 1 / 1

| 1

➶

reach

"Our data suggest that USPL1 is involved in snRNA transcription and support the view that Cajal bodies have a role in snRNP biogenesis."

24413172

USPL1 affects ZBED4

1 |

ZBED4 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

35575683

USPL1 affects Ubiquitin

| 1

USPL1 desumoylates Ubiquitin. 1 / 1

| 1

➶

reach

"It has recently been found that SUMO protease includes desumoylating isopeptidase 1 (DESI1), desumoylating isopeptidase 2 (DESI2) and ubiquitin specific protease like 1 (USPL1)."

29484374

USPL1 affects U2 snRNPs

| 1

USPL1 binds U2 snRNPs. 1 / 1

| 1

➶

reach

"USPL1 also interacts with U1 and U2 snRNPs and its knockdown causes a reduction in snRNA levels [XREF_BIBR]."

28615474

USPL1 affects U2 gene

| 1

USPL1 inhibits U2 gene. 1 / 1

| 1

➶

reach

"The results obtained by using two different antibodies clearly show a significant reduction in RNAPII occupancy at the U1 and U2 gene regions in cells treated with siRNA against USPL1 (XREF_FIG and supplementary material Fig."

24413172

USPL1 affects TSC2

1 |

TSC2 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

21653829

USPL1 affects TRIM5

| 1

USPL1 desumoylates TRIM5. 1 / 1

| 1

➶

sparser

"Mechanistically, deSUMOylation of TRIM5α by the deSUMOylating enzyme USPL1 in Cajal bodies allows TRIM5α to be sequestered in the nucleus, leading to efficient type I interferon responses by the DNA sensor cGAS during retroviral infection."

38280996

USPL1 affects TRIM17

1 |

TRIM17 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

37697039

USPL1 affects TPMT

1 |

USPL1 binds TPMT. 1 / 1

1 |

➶

biogrid

No evidence text available

33961781

USPL1 affects SUMO2-KG-TAMRA

| 1

USPL1 binds SUMO2-KG-TAMRA. 1 / 1

| 1

➶

reach

"USPL1 specifically bound SUMO2-KG-TAMRA as is evident from a concentration-dependent increase in fluorescence anisotropy but did not bind SUMO1- or Ub-KG-TAMRA (Figure S6F)."

37712884

USPL1 affects SUMO-2/3

| 1

USPL1 activates SUMO-2/3. 1 / 1

| 1

➶

reach

"Lastly, USPL1 preferably promotes SUMO-2/3 deconjugation and is located in Cajal bodies [XREF_BIBR, XREF_BIBR]."

32714579

USPL1 affects SUMO-2 deconjugation

| 1

USPL1 activates SUMO-2 deconjugation. 1 / 1

| 1

➶

eidos

"Lastly , USPL1 preferably promotes SUMO-2 / 3 deconjugation and is located in Cajal bodies [ 30,31 ] ."

32714579

USPL1 affects SP100

1 |

USPL1 binds SP100. 1 / 1

1 |

➶

biogrid

No evidence text available

22878415

USPL1 affects SNAPC4

1 |

SNAPC4 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

33961781

USPL1 affects SHMT2

1 |

SHMT2 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

22658674

USPL1 affects RNAPII

| 1

USPL1 increases the amount of RNAPII. 1 / 1

| 1

➶

reach

"Efficient knockdown of USPL1 by RNAi leads to reduced RNAPII mediated snRNA transcription, diminished production of snRNPs and altered pre-mRNA splicing."

24413172

USPL1 affects Protease

| 1

USPL1 desumoylates Protease. 1 / 1

| 1

➶

reach

"It has recently been found that SUMO protease includes desumoylating isopeptidase 1 (DESI1), desumoylating isopeptidase 2 (DESI2) and ubiquitin specific protease like 1 (USPL1)."

29484374

USPL1 affects POLR2A

1 |

USPL1 binds POLR2A. 1 / 1

1 |

➶

biogrid

No evidence text available

24413172

USPL1 affects PLIN1

1 |

PLIN1 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

35575683

USPL1 affects PKLR

1 |

USPL1 binds PKLR. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USPL1 affects PIP

1 |

USPL1 binds PIP. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USPL1 affects PGD

1 |

USPL1 binds PGD. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USPL1 affects P88992

1 |

USPL1 binds P88992. 1 / 1

1 |

➶

virhostnet

No evidence text available

22028648

USPL1 affects NXF1

1 |

NXF1 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

22658674

USPL1 affects NEK4

1 |

NEK4 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

25798074

USPL1 affects MYH9

1 |

MYH9 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

40437099

USPL1 affects MOV10

1 |

MOV10 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

22658674

USPL1 affects MMS19

1 |

MMS19 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

22678362

USPL1 affects KRT85

1 |

USPL1 binds KRT85. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USPL1 affects KRT4

1 |

USPL1 binds KRT4. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USPL1 affects KIF5B

1 |

USPL1 binds KIF5B. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USPL1 affects INTS11

| 1

USPL1 increases the amount of INTS11. 1 / 1

| 1

➶

reach

"Remarkably, the levels of INTS11 SUMOylation, but not those of INTS4 and INTS9, are modulated by USPL1 (Figure 2G–I; Supplementary Figure S2A)."

36454007

USPL1 affects IGHA2

1 |

USPL1 binds IGHA2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USPL1 affects HDAC2

| 1

USPL1 activates HDAC2. 1 / 1

| 1

➶

reach

"Whilst USP33 or USPL1 depletion increased the HDAC2 and HDAC1 ratio, we identified USP27X and the tumor suppressor BAP1 as DUBs whose depletion lead to the most significant decrease in the HDAC2 and HDAC1 ratio."

25970771

USPL1 affects HDAC1

| 1

USPL1 activates HDAC1. 1 / 1

| 1

➶

reach

25970771

USPL1 affects EPRS1

1 |

EPRS1 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

35575683

USPL1 affects DNA-templated transcription

| 1

USPL1 activates DNA-templated transcription. 1 / 1

| 1

➶

reach

"Importantly, we find that USPL1 associates directly with U snRNA loci and that it interacts and colocalises with components of the Little Elongation Complex, which is involved in RNAPII mediated snRNA transcription."

24413172

USPL1 affects DESI2

| 1

USPL1 desumoylates DESI2. 1 / 1

| 1

➶

reach

"It has recently been found that SUMO protease includes desumoylating isopeptidase 1 (DESI1), desumoylating isopeptidase 2 (DESI2) and ubiquitin specific protease like 1 (USPL1)."

29484374

USPL1 affects CKB

1 |

USPL1 binds CKB. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USPL1 affects CIAO2B

1 |

CIAO2B binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

23891004

USPL1 affects CBS

| 1

USPL1 activates CBS. 1 / 1

| 1

➶

reach

"When CBs were perturbed by siRNA knockdown of TCAB1 or USPL1, we could no longer observe the spatial clustering of previously examined sn/snoRNA loci and the histone loci (XREF_FIG)."

26997247

USPL1 affects AtRD22

| 1

USPL1 activates AtRD22. 1 / 1

| 1

➶

reach

"In the root, AtUSPL1 transcription is stimulated by exposure to either mannitol or NaCl, as is that of AtRD22 in the leaf XREF_BIBR."

25333723

USPL1 affects ANXA1

1 |

USPL1 binds ANXA1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USPL1 affects ANKFY1

1 |

USPL1 binds ANKFY1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USPL1 affects AHNAK

1 |

AHNAK binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

35575683

USPL1 affects AGO2

1 |

AGO2 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

18461144

USPL1 affects -U2 pre-snRNA

| 1

USPL1 inhibits -U2 pre-snRNA. 1 / 1

| 1

➶

reach

"Depletion of the essential CB components TCAB1 and WRAP53 or USPL1, which both lead to complete CB disassembly, decreases nascent precursor U1 and -U2 pre-snRNA levels [XREF_BIBR], whereas coilin depletion, which does not completely abolish CBs but results in residual CB like substructures, increases pre-U snRNA levels [XREF_BIBR]."

27767214

U2 snRNPs affects USPL1

| 1

USPL1 binds U2 snRNPs. 1 / 1

| 1

➶

reach

"USPL1 also interacts with U1 and U2 snRNPs and its knockdown causes a reduction in snRNA levels [XREF_BIBR]."

28615474

Triptolide affects USPL1

1 |

Triptolide increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

32835833

Tobacco Smoke Pollution affects USPL1

1 |

Tobacco Smoke Pollution increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

28065790

TSC2 affects USPL1

1 |

TSC2 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

21653829

TRIM17 affects USPL1

1 |

TRIM17 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

37697039

TPMT affects USPL1

1 |

USPL1 binds TPMT. 1 / 1

1 |

➶

biogrid

No evidence text available

33961781

TLX2 affects USPL1

1 |

TLX2 decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

T-2 toxin affects USPL1

1 |

T-2 toxin increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

36695871

SUMO2-KG-TAMRA affects USPL1

| 1

USPL1 binds SUMO2-KG-TAMRA. 1 / 1

| 1

➶

reach

"USPL1 specifically bound SUMO2-KG-TAMRA as is evident from a concentration-dependent increase in fluorescence anisotropy but did not bind SUMO1- or Ub-KG-TAMRA (Figure S6F)."

37712884

SPZ1 affects USPL1

1 |

SPZ1 decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

SP100 affects USPL1

1 |

USPL1 binds SP100. 1 / 1

1 |

➶

biogrid

No evidence text available

22878415

SP1 affects USPL1

1 |

SP1 decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

SNAPC4 affects USPL1

1 |

SNAPC4 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

33961781

SHMT2 affects USPL1

1 |

SHMT2 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

22658674

SCH 23390 affects USPL1

1 |

SCH 23390 increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

19564919

Plant Extracts affects USPL1

1 |

Plant Extracts increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

23557933

Pectins affects USPL1

1 |

Pectins decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

36331819

POLR2A affects USPL1

1 |

USPL1 binds POLR2A. 1 / 1

1 |

➶

biogrid

No evidence text available

24413172

PLIN1 affects USPL1

1 |

PLIN1 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

35575683

PKLR affects USPL1

1 |

USPL1 binds PKLR. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PIP affects USPL1

1 |

USPL1 binds PIP. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PGD affects USPL1

1 |

USPL1 binds PGD. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PCI 5002 affects USPL1

1 |

PCI 5002 increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

18593933

P88992 affects USPL1

1 |

USPL1 binds P88992. 1 / 1

1 |

➶

virhostnet

No evidence text available

22028648

NXF1 affects USPL1

1 |

NXF1 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

22658674

NEK4 affects USPL1

1 |

NEK4 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

25798074

N-acetyl-L-cysteine affects USPL1

1 |

N-acetyl-L-cysteine decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

18723479

MYH9 affects USPL1

1 |

MYH9 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

40437099

MOV10 affects USPL1

1 |

MOV10 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

22658674

MMS19 affects USPL1

1 |

MMS19 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

22678362

MIR320A affects USPL1

1 |

MIR320A decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

MAZ affects USPL1

1 |

MAZ decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

L-methionine affects USPL1

1 |

L-methionine demethylates USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

20938992

KRT85 affects USPL1

1 |

USPL1 binds KRT85. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

KRT4 affects USPL1

1 |

USPL1 binds KRT4. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

KIF5B affects USPL1

1 |

USPL1 binds KIF5B. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

IRF8 affects USPL1

1 |

IRF8 decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

IGHA2 affects USPL1

1 |

USPL1 binds IGHA2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

ICE1 affects ELL

| 1

USPL1 binds ICE1 and ELL. 1 / 1

| 1

➶

reach

"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."

22195968

Gentamicins affects USPL1

1 |

Gentamicins increases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

22061828

GABPB2 affects USPL1

1 |

GABPB2 decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

GABPA affects USPL1

1 |

GABPA decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

FOXO4 affects USPL1

1 |

FOXO4 decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

Environmental Pollutants affects USPL1

1 |

Environmental Pollutants decreases the amount of USPL1. 1 / 1

1 |

➶

ctd

No evidence text available

20064776

EPRS1 affects USPL1

1 |

EPRS1 binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

35575683

ELL affects ICE1, and USPL1

| 1

USPL1 binds ICE1 and ELL. 1 / 1

| 1

➶

reach

"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."

22195968

ELK1 affects USPL1

1 |

ELK1 decreases the amount of USPL1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

DESI1 affects USPL1

| 1

DESI1 desumoylates USPL1. 1 / 1

| 1

➶

reach

"Moreover, recent studies have identified three new SUMO proteases in humans, desumoylating isopeptidase 1 (DeSI1), DeSI2 18 and ubiquitin specific protease like 1 (USPL1) 19, which share little sequence similarity with the Ulp and SENP protease class."

23175280

COIL affects foci

| 1

COIL binds USPL1 and foci. 1 / 1

| 1

➶

sparser

"Upon knockdown of coilin, USPL1 still formed nuclear foci, similar to SMN ( xref , arrows in middle panel)."

24413172

CKB affects USPL1

1 |

USPL1 binds CKB. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

CIAO2B affects USPL1

1 |

CIAO2B binds USPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

23891004

CARM1 affects USPL1

| 1

CARM1 activates USPL1. 1 / 1

| 1

➶

reach

"As expected, re-introduction of wt CARM1 into the shCARM1 MN-1 cells rescued the Uspl1 E2 +/E2- ratios, returning them towards levels observed in the control condition."

26656492