IndraLab

Statements


USPL1 affects SUMO3
3 | 2
USPL1 binds SUMO3.
3 | 1
3 | 1

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"Here, we present the crystal structure of USPL1 bound to SUMO2, defining the key structural elements for the unusual deSUMOylase activity of USPL1."

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USPL1 activates SUMO3.
| 1
USPL1 activates SUMO3. 1 / 1
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"As shown in XREF_FIG C and 1D, SENP1, SENP2, SENP6, andSENP7, as well as USPL1, efficiently promoted global deconjugation of SUMO1 and SUMO2 from target substrates."
Bisphenol A affects USPL1
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Bisphenol A increases the amount of USPL1.
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Bisphenol A increases the amount of USPL1. 3 / 3
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Bisphenol A methylates USPL1.
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USPL1 affects LEC
| 4
| 4

sparser
"USPL1 interacts with LEC components involved in RNAPII-mediated snRNA transcription."

sparser
"To confirm the interaction of USPL1 with members of the LEC, we first used transient transfection of FLAG–ELL and HA–USPL1."

sparser
"Our findings, together with other data ( xref ), indicate an association of USPL1 with components of the LEC."

sparser
"Using a combination of fluorescence microscopy, molecular biology and proteomic approaches, we demonstrate that USPL1 interacts with components of the RNAPII-associated LEC and is associated with the U1 and U2 snRNA gene loci."
USPL1 affects ICE1
3 | 1
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USPL1 binds ELL and ICE1. 1 / 1
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"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."
USPL1 affects ELL
3 | 1
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USPL1 binds ELL and ICE1. 1 / 1
| 1

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"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."
SUMO3 affects USPL1
3 | 1
3 | 1

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"Here, we present the crystal structure of USPL1 bound to SUMO2, defining the key structural elements for the unusual deSUMOylase activity of USPL1."

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LEC affects USPL1
| 4
| 4

sparser
"USPL1 interacts with LEC components involved in RNAPII-mediated snRNA transcription."

sparser
"To confirm the interaction of USPL1 with members of the LEC, we first used transient transfection of FLAG–ELL and HA–USPL1."

sparser
"Our findings, together with other data ( xref ), indicate an association of USPL1 with components of the LEC."

sparser
"Using a combination of fluorescence microscopy, molecular biology and proteomic approaches, we demonstrate that USPL1 interacts with components of the RNAPII-associated LEC and is associated with the U1 and U2 snRNA gene loci."
ICE1 affects USPL1
3 | 1
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USPL1 binds ELL and ICE1. 1 / 1
| 1

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"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."
ELL affects USPL1
3 | 1
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USPL1 binds ELL and ICE1. 1 / 1
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"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."
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Pirinixic acid increases the amount of USPL1. 3 / 3
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USPL1 affects SUMO2
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USPL1 affects SUMO1
2 | 1
USPL1 binds SUMO1.
2 |
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USPL1 activates SUMO1.
| 1
USPL1 activates SUMO1. 1 / 1
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"As shown in XREF_FIG C and 1D, SENP1, SENP2, SENP6, andSENP7, as well as USPL1, efficiently promoted global deconjugation of SUMO1 and SUMO2 from target substrates."
USPL1 affects COIL
2 | 1
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USPL1 binds COIL and foci. 1 / 1
| 1

sparser
"Upon knockdown of coilin, USPL1 still formed nuclear foci, similar to SMN ( xref , arrows in middle panel)."
SUMO2 affects USPL1
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COIL affects USPL1
2 | 1
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USPL1 binds COIL and foci. 1 / 1
| 1

sparser
"Upon knockdown of coilin, USPL1 still formed nuclear foci, similar to SMN ( xref , arrows in middle panel)."
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Valproic acid decreases the amount of USPL1. 2 / 2
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Formaldehyde increases the amount of USPL1.
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Formaldehyde increases the amount of USPL1. 1 / 1
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Formaldehyde decreases the amount of USPL1.
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Formaldehyde decreases the amount of USPL1. 1 / 1
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Cyclosporin A increases the amount of USPL1. 2 / 2
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Cadmium dichloride increases the amount of USPL1.
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Cadmium dichloride increases the amount of USPL1. 1 / 1
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Aflatoxin B1 increases the amount of USPL1. 2 / 2
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SUMO1 affects USPL1
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PITX2 affects USPL1
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PITX2 decreases the amount of USPL1. 2 / 2
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Zinc atom affects USPL1
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Zinc atom increases the amount of USPL1. 1 / 1
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Thioacetamide increases the amount of USPL1. 1 / 1
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Tetrachloromethane increases the amount of USPL1. 1 / 1
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Sunitinib affects USPL1
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Sunitinib increases the amount of USPL1. 1 / 1
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Sodium dichromate increases the amount of USPL1. 1 / 1
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SnRNA gene loci affects USPL1
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USPL1 binds snRNA gene loci. 1 / 1
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"Therefore, we decided to investigate whether USPL1 itself could be found associated with snRNA gene loci."
Silver(0) affects USPL1
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Silver(0) increases the amount of USPL1. 1 / 1
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Selenium atom decreases the amount of USPL1. 1 / 1
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Schizandrin B increases the amount of USPL1. 1 / 1
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Response to heat affects USPL1
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Response to heat increases the amount of USPL1. 1 / 1
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"The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)."
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Pentachlorophenol decreases the amount of USPL1. 1 / 1
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Paracetamol affects USPL1
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Paracetamol increases the amount of USPL1. 1 / 1
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Mitotic G2 phase affects USPL1
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Mitotic G2 phase increases the amount of USPL1. 1 / 1
1 |

"Table I Genes with G2/M-specific and DNA damage-responsive expression: The relative increase in expression during G2 (as compared with S phase, i.e. at 7 h after release when compared with 1 h after release) is indicated in the third and fourth columns, and the average of these two independent analyses are in boldface type in the fifth column. "
Methyltestosterone increases the amount of USPL1. 1 / 1
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Methyl methanesulfonate increases the amount of USPL1. 1 / 1
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Methamphetamine increases the amount of USPL1. 1 / 1
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Mercury(0) affects USPL1
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Mercury(0) increases the amount of USPL1. 1 / 1
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Mercury dichloride increases the amount of USPL1. 1 / 1
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Lead diacetate decreases the amount of USPL1. 1 / 1
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Jinfukang affects USPL1
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Jinfukang decreases the amount of USPL1. 1 / 1
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Indometacin affects USPL1
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Indometacin increases the amount of USPL1. 1 / 1
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Hsa-miR-324-5p decreases the amount of USPL1. 1 / 1
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Hsa-miR-320a decreases the amount of USPL1. 1 / 1
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Gentamycin affects USPL1
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Gentamycin increases the amount of USPL1. 1 / 1
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Folic acid affects USPL1
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Folic acid demethylates USPL1. 1 / 1
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Foci affects USPL1
| 1
USPL1 binds COIL and foci. 1 / 1
| 1

sparser
"Upon knockdown of coilin, USPL1 still formed nuclear foci, similar to SMN ( xref , arrows in middle panel)."
Fenofibrate affects USPL1
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Fenofibrate increases the amount of USPL1. 1 / 1
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Elesclomol affects USPL1
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Elesclomol increases the amount of USPL1. 1 / 1
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Doxorubicin affects USPL1
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Doxorubicin decreases the amount of USPL1. 1 / 1
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Disulfiram affects USPL1
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Disulfiram decreases the amount of USPL1. 1 / 1
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Dicrotophos affects USPL1
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Dicrotophos decreases the amount of USPL1. 1 / 1
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Dexamethasone increases the amount of USPL1. 1 / 1
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Copper(II) sulfate increases the amount of USPL1. 1 / 1
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Copper atom affects USPL1
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Copper atom decreases the amount of USPL1. 1 / 1
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Choline affects USPL1
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Choline demethylates USPL1. 1 / 1
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Bis(2-ethylhexyl) phthalate decreases the amount of USPL1. 1 / 1
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Vitamin E affects USPL1
1 |
Vitamin E decreases the amount of USPL1. 1 / 1
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"Importantly, we find that USPL1 associates directly with U snRNA loci and that it interacts and colocalises with components of the Little Elongation Complex, which is involved in RNAPII mediated snRNA transcription."
USPL1 affects snRNA gene loci
| 1
USPL1 binds snRNA gene loci. 1 / 1
| 1

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"Therefore, we decided to investigate whether USPL1 itself could be found associated with snRNA gene loci."
USPL1 affects gus
| 1
USPL1 increases the amount of gus. 1 / 1
| 1

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"AtUSPL1 expression was also assayed by tracking GUS expression produced by the pAtUSPL1 : : GUS transgene."
USPL1 affects foci
| 1
USPL1 binds COIL and foci. 1 / 1
| 1

sparser
"Upon knockdown of coilin, USPL1 still formed nuclear foci, similar to SMN ( xref , arrows in middle panel)."

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"Our data suggest that USPL1 is involved in snRNA transcription and support the view that Cajal bodies have a role in snRNP biogenesis."
USPL1 affects Ubiquitin
| 1
USPL1 desumoylates Ubiquitin. 1 / 1
| 1

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"It has recently been found that SUMO protease includes desumoylating isopeptidase 1 (DESI1), desumoylating isopeptidase 2 (DESI2) and ubiquitin specific protease like 1 (USPL1)."
USPL1 affects U2 snRNPs
| 1
USPL1 binds U2 snRNPs. 1 / 1
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"USPL1 also interacts with U1 and U2 snRNPs and its knockdown causes a reduction in snRNA levels [XREF_BIBR]."
USPL1 affects U2 gene
| 1
USPL1 inhibits U2 gene. 1 / 1
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"The results obtained by using two different antibodies clearly show a significant reduction in RNAPII occupancy at the U1 and U2 gene regions in cells treated with siRNA against USPL1 (XREF_FIG and supplementary material Fig."
USPL1 affects SUMO-2/3
| 1
USPL1 activates SUMO-2/3. 1 / 1
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"Lastly, USPL1 preferably promotes SUMO-2/3 deconjugation and is located in Cajal bodies [XREF_BIBR, XREF_BIBR]."
USPL1 affects SUMO-2 deconjugation
| 1
USPL1 activates SUMO-2 deconjugation. 1 / 1
| 1

eidos
"Lastly , USPL1 preferably promotes SUMO-2 / 3 deconjugation and is located in Cajal bodies [ 30,31 ] ."
USPL1 affects SP100
1 |
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USPL1 affects SHMT2
1 |
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USPL1 affects RNAPII
| 1
USPL1 increases the amount of RNAPII. 1 / 1
| 1

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"Efficient knockdown of USPL1 by RNAi leads to reduced RNAPII mediated snRNA transcription, diminished production of snRNPs and altered pre-mRNA splicing."
USPL1 affects RANGAP1
1 |
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USPL1 affects Protease
| 1
USPL1 desumoylates Protease. 1 / 1
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"It has recently been found that SUMO protease includes desumoylating isopeptidase 1 (DESI1), desumoylating isopeptidase 2 (DESI2) and ubiquitin specific protease like 1 (USPL1)."
USPL1 affects POLR2A
1 |
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USPL1 affects PKLR
1 |
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USPL1 affects PIP
1 |
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USPL1 affects PGD
1 |
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USPL1 affects P88992
1 |
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USPL1 affects NXF1
1 |
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USPL1 affects MOV10
1 |
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USPL1 affects MMS19
1 |
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USPL1 affects KRT85
1 |
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USPL1 affects KRT4
1 |
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USPL1 affects KIF5B
1 |
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USPL1 affects IGHA2
1 |
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USPL1 affects HDAC2
| 1
USPL1 activates HDAC2. 1 / 1
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"Whilst USP33 or USPL1 depletion increased the HDAC2 and HDAC1 ratio, we identified USP27X and the tumor suppressor BAP1 as DUBs whose depletion lead to the most significant decrease in the HDAC2 and HDAC1 ratio."
USPL1 affects HDAC1
| 1
USPL1 activates HDAC1. 1 / 1
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"Whilst USP33 or USPL1 depletion increased the HDAC2 and HDAC1 ratio, we identified USP27X and the tumor suppressor BAP1 as DUBs whose depletion lead to the most significant decrease in the HDAC2 and HDAC1 ratio."
USPL1 affects HACD1
| 1
| 1

sparser
"This is consistent with the fact that we did not observe nucleolar cap formation upon knockdown of USPL1, which would be expected upon a general inhibition of transcription ( xref ; xref )."
USPL1 affects EAF1
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USPL1 affects DESI2
| 1
USPL1 desumoylates DESI2. 1 / 1
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"It has recently been found that SUMO protease includes desumoylating isopeptidase 1 (DESI1), desumoylating isopeptidase 2 (DESI2) and ubiquitin specific protease like 1 (USPL1)."
USPL1 affects CKB
1 |
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USPL1 affects CIAO2B
1 |
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USPL1 affects CBS
| 1
USPL1 activates CBS. 1 / 1
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"When CBs were perturbed by siRNA knockdown of TCAB1 or USPL1, we could no longer observe the spatial clustering of previously examined sn/snoRNA loci and the histone loci (XREF_FIG)."
USPL1 affects AtRD22
| 1
USPL1 activates AtRD22. 1 / 1
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"In the root, AtUSPL1 transcription is stimulated by exposure to either mannitol or NaCl, as is that of AtRD22 in the leaf XREF_BIBR."
USPL1 affects ANXA1
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No evidence text available
USPL1 affects ANKFY1
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USPL1 affects -U2 pre-snRNA
| 1
USPL1 inhibits -U2 pre-snRNA. 1 / 1
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"Depletion of the essential CB components TCAB1 and WRAP53 or USPL1, which both lead to complete CB disassembly, decreases nascent precursor U1 and -U2 pre-snRNA levels [XREF_BIBR], whereas coilin depletion, which does not completely abolish CBs but results in residual CB like substructures, increases pre-U snRNA levels [XREF_BIBR]."
U2 snRNPs affects USPL1
| 1
USPL1 binds U2 snRNPs. 1 / 1
| 1

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"USPL1 also interacts with U1 and U2 snRNPs and its knockdown causes a reduction in snRNA levels [XREF_BIBR]."
Tobacco Smoke Pollution increases the amount of USPL1. 1 / 1
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No evidence text available
TLX2 affects USPL1
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TLX2 decreases the amount of USPL1. 1 / 1
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No evidence text available
SPZ1 affects USPL1
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SPZ1 decreases the amount of USPL1. 1 / 1
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No evidence text available
SP100 affects USPL1
1 |
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SP1 affects USPL1
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SP1 decreases the amount of USPL1. 1 / 1
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No evidence text available
SHMT2 affects USPL1
1 |
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SCH 23390 affects USPL1
1 |
SCH 23390 increases the amount of USPL1. 1 / 1
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No evidence text available
RANGAP1 affects USPL1
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No evidence text available
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Plant Extracts increases the amount of USPL1. 1 / 1
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No evidence text available
POLR2A affects USPL1
1 |
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No evidence text available
PKLR affects USPL1
1 |
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No evidence text available
PIP affects USPL1
1 |
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No evidence text available
PGD affects USPL1
1 |
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No evidence text available
PCI 5002 affects USPL1
1 |
PCI 5002 increases the amount of USPL1. 1 / 1
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No evidence text available
P88992 affects USPL1
1 |
1 |

No evidence text available
Niclosamide affects USPL1
1 |
Niclosamide increases the amount of USPL1. 1 / 1
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No evidence text available
NXF1 affects USPL1
1 |
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No evidence text available
N-acetyl-L-cysteine increases the amount of USPL1. 1 / 1
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No evidence text available
MOV10 affects USPL1
1 |
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No evidence text available
MMS19 affects USPL1
1 |
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No evidence text available
MAZ affects USPL1
1 |
MAZ decreases the amount of USPL1. 1 / 1
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No evidence text available
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L-methionine demethylates USPL1. 1 / 1
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No evidence text available
KRT85 affects USPL1
1 |
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No evidence text available
KRT4 affects USPL1
1 |
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No evidence text available
KIF5B affects USPL1
1 |
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No evidence text available
IRF8 affects USPL1
1 |
IRF8 decreases the amount of USPL1. 1 / 1
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No evidence text available
IGHA2 affects USPL1
1 |
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No evidence text available
ICE1 affects ELL
| 1
USPL1 binds ELL and ICE1. 1 / 1
| 1

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"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."
HACD1 affects USPL1
| 1
| 1

sparser
"This is consistent with the fact that we did not observe nucleolar cap formation upon knockdown of USPL1, which would be expected upon a general inhibition of transcription ( xref ; xref )."
GABPB2 affects USPL1
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GABPB2 decreases the amount of USPL1. 1 / 1
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No evidence text available
GABPA affects USPL1
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GABPA decreases the amount of USPL1. 1 / 1
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No evidence text available
FOXO4 affects USPL1
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FOXO4 decreases the amount of USPL1. 1 / 1
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No evidence text available
Environmental Pollutants decreases the amount of USPL1. 1 / 1
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No evidence text available
ELL affects ICE1, and USPL1
| 1
USPL1 binds ELL and ICE1. 1 / 1
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"However, USPL1 was not identified in our ELL1-3 or MLL-ELL purifications, so the generality of an USPL1, ICE1, and ELL complex remains to be determined."
ELK1 affects USPL1
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ELK1 decreases the amount of USPL1. 1 / 1
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No evidence text available
EAF1 affects USPL1
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No evidence text available
DESI1 affects USPL1
| 1
DESI1 desumoylates USPL1. 1 / 1
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"Moreover, recent studies have identified three new SUMO proteases in humans, desumoylating isopeptidase 1 (DeSI1), DeSI2 18 and ubiquitin specific protease like 1 (USPL1) 19, which share little sequence similarity with the Ulp and SENP protease class."
COIL affects foci
| 1
USPL1 binds COIL and foci. 1 / 1
| 1

sparser
"Upon knockdown of coilin, USPL1 still formed nuclear foci, similar to SMN ( xref , arrows in middle panel)."
CKB affects USPL1
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No evidence text available
CIAO2B affects USPL1
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No evidence text available
CARM1 affects USPL1
| 1
CARM1 activates USPL1. 1 / 1
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"As expected, re-introduction of wt CARM1 into the shCARM1 MN-1 cells rescued the Uspl1 E2 +/E2- ratios, returning them towards levels observed in the control condition."
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Aroclor 1254 decreases the amount of USPL1. 1 / 1
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No evidence text available
ANXA1 affects USPL1
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No evidence text available
ANKFY1 affects USPL1
1 |
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No evidence text available
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No evidence text available
2-hydroxypropanoic acid increases the amount of USPL1. 1 / 1
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No evidence text available
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17beta-estradiol increases the amount of USPL1. 1 / 1
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No evidence text available
17alpha-ethynylestradiol increases the amount of USPL1. 1 / 1
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No evidence text available