IndraLab

Statements

USP9Y affects DDX3Y
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USP9Y activates DDX3Y.
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USP9Y activates DDX3Y. 4 / 4
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"The AZFa sub-region comprises three candidate genes- DDX3Y (former name DBY), USP9Y and UTY and mutation in these genes leads to absence of spermatogenic cells."
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"Notably, protein expression of DDX3Y decreased by USP9Y silencing was inhibited after MG132 treatment, which indicated that USP9Y prevented DDX3Y degradation by the proteasome in SPC-A1 cells ( Fig. 5[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition to overexpression of Y-chromosome-related transcripts (n = 18), such as USP9Y (FC> 13.1), DDX3Y (FC> 11.3), RPS4Y1 (FC> 9.9), and EIF1AY (FC> 11.8) in males, there was overexpression of CD24 (FC> 5.6) and KCNK1 (FC> 1.5)."
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"We also found that USP9Y overexpression decreased polyubiquitination and increased the half-life of DDX3Y in SPC-A1 cells ( Fig. 5 F)."
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USP9Y binds DDX3Y.
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DDX3Y binds USP9Y. 3 / 3
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"Based on the results we described above, the molecular mechanism by which USP9Y binds to DDX3Y protein and prevents its degradation via deubiquitination was depicted in Fig. 9 ."
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"USP9Y bound with DDX3Y and prevented the degradation of DDX3Y via deubiquitination."
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"We then explored the interaction of DDX3Y and USP9Y with SMAD4 using CoIP assays, and DDX3Y and USP9Y enriched in the precipitates of SMAD4 antibody, and SMAD4 and USP9Y also enriched in DDX3Y antibod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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USP9Y increases the amount of DDX3Y.
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USP9Y increases the amount of DDX3Y. 1 / 1
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"Notably, protein expression of DDX3Y decreased by USP9Y silencing was inhibited after MG132 treatment, which indicated that USP9Y prevented DDX3Y degradation by the proteasome in SPC-A1 cells ( Fig. 5[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The colony formation ability of LC cells was significantly decreased in the OE-USP9Y group, indicating that USP9Y overexpression inhibited LC cell proliferation in vitro ( Fig. 2 C)."
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"According to the results of IHC staining, the Ki67 protein expression exhibited evident decrease in the Lv-USP9Y group relative to the control group, which suggested that USP9Y suppressed LC cell prol[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP9Y overexpression was demonstrated to suppress LC cell proliferation and cell cycle process and promoted cell apoptosis in vitro."
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USP9Y affects apoptotic process
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USP9Y activates apoptotic process. 3 / 3
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"Moreover, we also revealed that USP9Y overexpression inhibited xenograft tumor growth and promoted tumor cell apoptosis in vivo."
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"The TUNEL assay exhibited that USP9Y increased the ratio of TUNEL-positive cells in tumor tissues, suggesting that USP9Y promoted LC cell apoptosis in vivo ( Fig. 3 E)."
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"USP9Y overexpression was demonstrated to suppress LC cell proliferation and cell cycle process and promoted cell apoptosis in vitro."
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DDX3Y affects USP9Y
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DDX3Y binds USP9Y. 3 / 3
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"Based on the results we described above, the molecular mechanism by which USP9Y binds to DDX3Y protein and prevents its degradation via deubiquitination was depicted in Fig. 9 ."
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"USP9Y bound with DDX3Y and prevented the degradation of DDX3Y via deubiquitination."
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"We then explored the interaction of DDX3Y and USP9Y with SMAD4 using CoIP assays, and DDX3Y and USP9Y enriched in the precipitates of SMAD4 antibody, and SMAD4 and USP9Y also enriched in DDX3Y antibod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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USP9Y affects Azoospermia
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USP9Y activates Azoospermia. 2 / 2
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"A de novo point mutation in the USP9Y gene on the Y chromosome causes non-obstructive azoospermia, as was recently discovered in a male [123]."
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"4, 5 Azoospermia, oligozoospermia, and oligoasthenozoospermia are caused by shortening or loss of the USP9Y gene."
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USP9Y
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USP9Y translocates to the X chromosome. 1 / 1
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"This combined probe generated a signal only on the E. lutescens X Chromosome (Fig. 3A), strongly indicating that Usp9y and Zfy have been translocated from the Y to the X Chromosome."
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USP9Y affects spermatogenesis
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USP9Y activates spermatogenesis. 1 / 1
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"One possible implication of this is that while USP9Y contributes to spermatogenesis, it does not cause SCOS."
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"USP9Y overexpression was demonstrated to suppress LC cell proliferation and cell cycle process and promoted cell apoptosis in vitro."
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USP9Y affects USP9X
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USP9Y activates USP9X. 1 / 1
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"USP9Y expression therefore completely restores the USP9X dosage imbalance between males and females."
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USP9Y affects TUNEL
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USP9Y activates TUNEL. 1 / 1
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"The TUNEL assay exhibited that USP9Y increased the ratio of TUNEL-positive cells in tumor tissues, suggesting that USP9Y promoted LC cell apoptosis in vivo ( Fig. 3 E)."
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USP9Y affects SMAD4
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SMAD4 binds USP9Y and 8 C. 1 / 1
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"We then explored the interaction of DDX3Y and USP9Y with SMAD4 using CoIP assays, and DDX3Y and USP9Y enriched in the precipitates of SMAD4 antibody, and SMAD4 and USP9Y also enriched in DDX3Y antibod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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USP9Y affects RPS4Y1
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USP9Y activates RPS4Y1. 1 / 1
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"In addition to overexpression of Y-chromosome-related transcripts (n = 18), such as USP9Y (FC> 13.1), DDX3Y (FC> 11.3), RPS4Y1 (FC> 9.9), and EIF1AY (FC> 11.8) in males, there was overexpression of CD24 (FC> 5.6) and KCNK1 (FC> 1.5)."
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USP9Y affects Oligospermia
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USP9Y activates Oligospermia. 1 / 1
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"4, 5 Azoospermia, oligozoospermia, and oligoasthenozoospermia are caused by shortening or loss of the USP9Y gene."
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USP9Y affects Neoplasms
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USP9Y inhibits Neoplasms. 1 / 1
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"Moreover, we also revealed that USP9Y overexpression inhibited xenograft tumor growth and promoted tumor cell apoptosis in vivo."
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USP9Y activates Neoplasm Metastasis. 1 / 1
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"UTY and USP9Y are involved in demethylation and deubiquitination [25], respectively, and may potentially promote bone metastasis by modulating the immune microenvironment [26,27]."
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USP9Y affects Infertility
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USP9Y activates Infertility. 1 / 1
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"We also generated an animal model of the AZoospermia Factor a (AZFa) deletion, encompassing Usp9y, Uty, and Ddx3y, which in men causes the most severe form of infertility characterized by a complete absence of germ cells (28)."
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USP9Y affects Figure6
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USP9Y activates Figure6. 1 / 1
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"Whereas, Guanine deaminase, Glycogen(starch) synthase, Hyaluronan synthase, Aspartoacylase, Diacylglycerol O-acyltransferase, Pyroglutamyl-peptidase II and Ubiquitin thiol esterase were involved in this subnetwork that enriched with GDA, GYS2, HAS3, ASPA, TRHDE, DGAT2, USP9Y, USP44 genes from gene list of downregulated mRNAs of stage II.Considering FUT3 from gene list of upregulated mRNAs of stage II (Figure6)."
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USP9Y affects EIF1AY
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USP9Y activates EIF1AY. 1 / 1
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"In addition to overexpression of Y-chromosome-related transcripts (n = 18), such as USP9Y (FC> 13.1), DDX3Y (FC> 11.3), RPS4Y1 (FC> 9.9), and EIF1AY (FC> 11.8) in males, there was overexpression of CD24 (FC> 5.6) and KCNK1 (FC> 1.5)."
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USP9Y affects DEGs
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USP9Y activates DEGs. 1 / 1
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"Ubiquitin specific peptidase 9 Y linked (USP9Y), ribosomal protein S4 Y linked 1 (RPS4Y1) and eukaryotic translation initiation factor 1A Y linked (EIF1AY) were significantly upregulated DEGs in the present study."
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USP9Y affects BMPRIA mRNA
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USP9Y activates BMPRIA mRNA. 1 / 1
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"Furthermore, since SMAD4 can participate in both the BMP and TGF-β pathways, to provide stronger evidence for a critical role for the DDX3Y-BMP pathway than for the TGF-β pathway in LC, we detected th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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USP9Y affects 8 C
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SMAD4 binds USP9Y and 8 C. 1 / 1
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"We then explored the interaction of DDX3Y and USP9Y with SMAD4 using CoIP assays, and DDX3Y and USP9Y enriched in the precipitates of SMAD4 antibody, and SMAD4 and USP9Y also enriched in DDX3Y antibod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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