IndraLab

Statements

USP9Y activates DDX3Y.

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USP9Y activates DDX3Y. 4 / 4

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"The AZFa sub-region comprises three candidate genes- DDX3Y (former name DBY), USP9Y and UTY and mutation in these genes leads to absence of spermatogenic cells."

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"Notably, protein expression of DDX3Y decreased by USP9Y silencing was inhibited after MG132 treatment, which indicated that USP9Y prevented DDX3Y degradation by the proteasome in SPC-A1 cells ( Fig. 5[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"In addition to overexpression of Y-chromosome-related transcripts (n = 18), such as USP9Y (FC> 13.1), DDX3Y (FC> 11.3), RPS4Y1 (FC> 9.9), and EIF1AY (FC> 11.8) in males, there was overexpression of CD24 (FC> 5.6) and KCNK1 (FC> 1.5)."

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"We also found that USP9Y overexpression decreased polyubiquitination and increased the half-life of DDX3Y in SPC-A1 cells ( Fig. 5 F)."

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USP9Y binds DDX3Y.

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DDX3Y binds USP9Y. 3 / 3

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"Based on the results we described above, the molecular mechanism by which USP9Y binds to DDX3Y protein and prevents its degradation via deubiquitination was depicted in Fig. 9 ."

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"USP9Y bound with DDX3Y and prevented the degradation of DDX3Y via deubiquitination."

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"We then explored the interaction of DDX3Y and USP9Y with SMAD4 using CoIP assays, and DDX3Y and USP9Y enriched in the precipitates of SMAD4 antibody, and SMAD4 and USP9Y also enriched in DDX3Y antibod[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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USP9Y increases the amount of DDX3Y.

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USP9Y increases the amount of DDX3Y. 1 / 1

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USP9Y affects cell population proliferation

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USP9Y inhibits cell population proliferation. 3 / 3

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"The colony formation ability of LC cells was significantly decreased in the OE-USP9Y group, indicating that USP9Y overexpression inhibited LC cell proliferation in vitro ( Fig. 2 C)."

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"According to the results of IHC staining, the Ki67 protein expression exhibited evident decrease in the Lv-USP9Y group relative to the control group, which suggested that USP9Y suppressed LC cell prol[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"USP9Y overexpression was demonstrated to suppress LC cell proliferation and cell cycle process and promoted cell apoptosis in vitro."

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USP9Y affects apoptotic process

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USP9Y activates apoptotic process. 3 / 3

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"Moreover, we also revealed that USP9Y overexpression inhibited xenograft tumor growth and promoted tumor cell apoptosis in vivo."

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"The TUNEL assay exhibited that USP9Y increased the ratio of TUNEL-positive cells in tumor tissues, suggesting that USP9Y promoted LC cell apoptosis in vivo ( Fig. 3 E)."

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"USP9Y overexpression was demonstrated to suppress LC cell proliferation and cell cycle process and promoted cell apoptosis in vitro."

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DDX3Y affects USP9Y

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DDX3Y binds USP9Y. 3 / 3

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"Based on the results we described above, the molecular mechanism by which USP9Y binds to DDX3Y protein and prevents its degradation via deubiquitination was depicted in Fig. 9 ."

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"USP9Y bound with DDX3Y and prevented the degradation of DDX3Y via deubiquitination."

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Benzo[a]pyrene affects USP9Y

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Benzo[a]pyrene decreases the amount of USP9Y. 2 / 2

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ctd

No evidence text available

20106945

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ctd

No evidence text available

21632981

Arsenite(3-) affects USP9Y

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Arsenite(3-) increases the amount of USP9Y.

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Arsenite(3-) increases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

23974009

Arsenite(3-) demethylates USP9Y.

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Arsenite(3-) demethylates USP9Y. 1 / 1

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ctd

No evidence text available

23974009

Aflatoxin B1 affects USP9Y

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Aflatoxin B1 methylates USP9Y.

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Aflatoxin B1 methylates USP9Y. 1 / 1

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ctd

No evidence text available

27153756

Aflatoxin B1 increases the amount of USP9Y.

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Aflatoxin B1 increases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

27153756

ZNF331 affects USP9Y

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ZNF331 binds USP9Y. 2 / 2

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biogrid

No evidence text available

28514442

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biogrid

No evidence text available

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USP9Y affects USP9X

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USP9Y binds USP9X.

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USP9Y binds USP9X. 1 / 1

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biogrid

No evidence text available

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USP9Y activates USP9X.

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USP9Y activates USP9X. 1 / 1

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"USP9Y expression therefore completely restores the USP9X dosage imbalance between males and females."

18208332

USP9Y affects SMAD4

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USP9Y deubiquitinates SMAD4.

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USP9Y deubiquitinates SMAD4. 1 / 1

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ubibrowser

No evidence text available

USP9Y binds SMAD4.

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SMAD4 binds USP9Y and 8 C. 1 / 1

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USP9Y affects RPS6

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USP9Y binds RPS6. 2 / 2

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biogrid

No evidence text available

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biogrid

No evidence text available

30021884

USP9Y affects NCKIPSD

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NCKIPSD binds USP9Y. 2 / 2

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biogrid

No evidence text available

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biogrid

No evidence text available

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USP9Y affects CLK3

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CLK3 binds USP9Y. 2 / 2

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biogrid

No evidence text available

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biogrid

No evidence text available

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USP9Y affects Azoospermia

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USP9Y activates Azoospermia. 2 / 2

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"A de novo point mutation in the USP9Y gene on the Y chromosome causes non-obstructive azoospermia, as was recently discovered in a male [123]."

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"4, 5 Azoospermia, oligozoospermia, and oligoasthenozoospermia are caused by shortening or loss of the USP9Y gene."

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RPS6 affects USP9Y

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USP9Y binds RPS6. 2 / 2

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biogrid

No evidence text available

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biogrid

No evidence text available

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USP9Y is modified

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USP9Y is phosphorylated. 1 / 1

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"As outlined in Fig. 6a, previous evidence from the literature shows that USP9 can influence the phosphorylation of MAPT both by deubiquitinating the kinase MARK4 [26], which directly phosphorylates MAPT, and by deubiquitinating SNCA [30], which mediates the connection between glycogen synthase kinase 3β (GSK3B) and its phosphorylation target MAPT [31]."

27878758

USP9Y is phosphorylated on Y1233. 1 / 1

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hprd

No evidence text available

19664994

NCKIPSD affects USP9Y

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NCKIPSD binds USP9Y. 2 / 2

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biogrid

No evidence text available

28514442

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biogrid

No evidence text available

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CLK3 affects USP9Y

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CLK3 binds USP9Y. 2 / 2

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biogrid

No evidence text available

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biogrid

No evidence text available

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Tetrachloroethene affects USP9Y

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Tetrachloroethene decreases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

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Potassium chromate affects USP9Y

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Potassium chromate decreases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

22714537

IncobotulinumtoxinA affects USP9Y

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IncobotulinumtoxinA decreases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

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Formaldehyde affects USP9Y

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Formaldehyde decreases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

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Doxorubicin affects USP9Y

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Doxorubicin decreases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

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Cyclosporin A affects USP9Y

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Cyclosporin A decreases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

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Chromium atom affects USP9Y

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Chromium atom decreases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

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Caffeine affects USP9Y

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Caffeine phosphorylates USP9Y. 1 / 1

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ctd

No evidence text available

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Butanal affects USP9Y

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Butanal decreases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

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ZRANB1 affects USP9Y

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ZRANB1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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ZFP36L2 affects USP9Y

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ZFP36L2 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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ZEB1 affects USP9Y

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ZEB1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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Vanadates affects USP9Y

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Vanadates increases the amount of USP9Y. 1 / 1

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ctd

No evidence text available

22714537

VSX1 affects USP9Y

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VSX1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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VCPIP1 affects USP9Y

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VCPIP1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y

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USP9Y translocates to the X chromosome. 1 / 1

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"This combined probe generated a signal only on the E. lutescens X Chromosome (Fig. 3A), strongly indicating that Usp9y and Zfy have been translocated from the Y to the X Chromosome."

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USP9Y affects spermatogenesis

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USP9Y activates spermatogenesis. 1 / 1

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"One possible implication of this is that while USP9Y contributes to spermatogenesis, it does not cause SCOS."

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USP9Y affects cell cycle process

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USP9Y inhibits cell cycle process. 1 / 1

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"USP9Y overexpression was demonstrated to suppress LC cell proliferation and cell cycle process and promoted cell apoptosis in vitro."

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USP9Y affects ZRANB1

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ZRANB1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

35944360

USP9Y affects ZFP36L2

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ZFP36L2 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects ZEB1

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ZEB1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects VSX1

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VSX1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects VCPIP1

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VCPIP1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects UBC

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USP9Y binds UBC. 1 / 1

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biogrid

No evidence text available

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USP9Y affects TUNEL

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USP9Y activates TUNEL. 1 / 1

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"The TUNEL assay exhibited that USP9Y increased the ratio of TUNEL-positive cells in tumor tissues, suggesting that USP9Y promoted LC cell apoptosis in vivo ( Fig. 3 E)."

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USP9Y affects TK

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TK binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects TESK2

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TESK2 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects TAGLN

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TAGLN binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects SOCS1

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SOCS1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects SIRT1

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SIRT1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects SHC1

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SHC1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects RSPH1

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RSPH1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects RPS4Y1

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USP9Y activates RPS4Y1. 1 / 1

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USP9Y affects ROR1

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ROR1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects RAMAC

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RAMAC binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects Q98143

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USP9Y binds Q98143. 1 / 1

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virhostnet

No evidence text available

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USP9Y affects PYCR1

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PYCR1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects PRKN

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PRKN binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects PRKD1

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PRKD1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects PMS1

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PMS1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects PLEKHA4

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PLEKHA4 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects PHB1

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PHB1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects Oligospermia

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USP9Y activates Oligospermia. 1 / 1

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"4, 5 Azoospermia, oligozoospermia, and oligoasthenozoospermia are caused by shortening or loss of the USP9Y gene."

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USP9Y affects Neoplasms

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USP9Y inhibits Neoplasms. 1 / 1

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"Moreover, we also revealed that USP9Y overexpression inhibited xenograft tumor growth and promoted tumor cell apoptosis in vivo."

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USP9Y affects Neoplasm Metastasis

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USP9Y activates Neoplasm Metastasis. 1 / 1

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"UTY and USP9Y are involved in demethylation and deubiquitination [25], respectively, and may potentially promote bone metastasis by modulating the immune microenvironment [26,27]."

| PMC

USP9Y affects MECP2

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MECP2 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects MATR3

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MATR3 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects MAPT

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USP9Y binds MAPT. 1 / 1

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hprd

No evidence text available

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USP9Y affects MAP2K3

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MAP2K3 binds USP9Y. 1 / 1

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biogrid

No evidence text available

31980649

USP9Y affects LINC02912

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LINC02912 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects KIF23

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KIF23 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects KIF20A

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KIF20A binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects KIF14

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KIF14 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects KIAA0408

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KIAA0408 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects KANSL3

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KANSL3 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects Infertility

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USP9Y activates Infertility. 1 / 1

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"We also generated an animal model of the AZoospermia Factor a (AZFa) deletion, encompassing Usp9y, Uty, and Ddx3y, which in men causes the most severe form of infertility characterized by a complete absence of germ cells (28)."

39847625

USP9Y affects Hsph1

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Hsph1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects HS2ST1

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HS2ST1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

28514442

USP9Y affects HEXIM1

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HEXIM1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

29845934

USP9Y affects Figure6

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USP9Y activates Figure6. 1 / 1

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"Whereas, Guanine deaminase, Glycogen(starch) synthase, Hyaluronan synthase, Aspartoacylase, Diacylglycerol O-acyltransferase, Pyroglutamyl-peptidase II and Ubiquitin thiol esterase were involved in this subnetwork that enriched with GDA, GYS2, HAS3, ASPA, TRHDE, DGAT2, USP9Y, USP44 genes from gene list of downregulated mRNAs of stage II.Considering FUT3 from gene list of upregulated mRNAs of stage II (Figure6)."

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USP9Y affects FBXO22

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FBXO22 binds USP9Y. 1 / 1

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biogrid

No evidence text available

36774506

USP9Y affects EIF4B

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EIF4B binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects EIF1AY

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USP9Y activates EIF1AY. 1 / 1

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20031959

USP9Y affects ECT2

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ECT2 binds USP9Y. 1 / 1

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biogrid

No evidence text available

31586073

USP9Y affects DEGs

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USP9Y activates DEGs. 1 / 1

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"Ubiquitin specific peptidase 9 Y linked (USP9Y), ribosomal protein S4 Y linked 1 (RPS4Y1) and eukaryotic translation initiation factor 1A Y linked (EIF1AY) were significantly upregulated DEGs in the present study."

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USP9Y affects DDHD1

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DDHD1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

33961781

USP9Y affects DCLRE1C

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DCLRE1C binds USP9Y. 1 / 1

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biogrid

No evidence text available

33961781

USP9Y affects CSNK1E

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CSNK1E binds USP9Y. 1 / 1

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biogrid

No evidence text available

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USP9Y affects CFAP96

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CFAP96 binds USP9Y. 1 / 1

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biogrid

No evidence text available

33961781

USP9Y affects CES1P1

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CES1P1 binds USP9Y. 1 / 1

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biogrid

No evidence text available

33961781

USP9Y affects CCL16

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CCL16 binds USP9Y. 1 / 1

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biogrid

No evidence text available

33961781

USP9Y affects CCDC9

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CCDC9 binds USP9Y. 1 / 1

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biogrid

No evidence text available

33961781

USP9Y affects BMPRIA mRNA

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USP9Y activates BMPRIA mRNA. 1 / 1

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"Furthermore, since SMAD4 can participate in both the BMP and TGF-β pathways, to provide stronger evidence for a critical role for the DDX3Y-BMP pathway than for the TGF-β pathway in LC, we detected th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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