IndraLab

Statements

PTPN23 binds USP8.
1 | 4 3
USP8 binds PTPN23. 6 / 7
1 | 4 1
biogrid
No evidence text available
23477725
reach
"Based on these studies, we propose a model whereby the concerted recruitment of CHMP4B and UBPY to HD-PTP and the engagement of UBPY by STAM2 displaces ESCRT-0 from HD-PTP, deubiquitinates EGFR, and releases ESCRT-0 from cargo in favor of ESCRT-III."
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reach
"Association of UBPY with HD-PTP involves UBPY interacting with HD-PTP-bound CHMP4B, as well as additional interaction (s) between UBPY and HD-PTP."
23477725
sparser
"Association of UBPY with HD-PTP involves UBPY interacting with HD-PTP-bound CHMP4B, as well as additional interaction(s) between UBPY and HD-PTP."
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"Hence, like STAM2, UBPY may bind HD-PTP at multiple sites."
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"We investigated in more detail how UBPY bound HD-PTP Bro1-V."
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USP8 binds PTPN23, CHMP4B, and BRO1. 1 / 1
| 1
sparser
"Altogether, these data indicate that CHMP4B binds the MIT domain of UBPY and the HD-PTP Bro1 domain simultaneously, though it is formally possible that CHMP4B additionally activates UBPY MIT to bind H[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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STAM2 binds USP8 and PTPN23. 1 / 1
| 1
sparser
"Hence, like STAM2, UBPY may bind HD-PTP at multiple sites."
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PTPN23 inhibits USP8.
| 1
PTPN23 inhibits USP8. 1 / 1
| 1
reach
"Indeed, depleting HD-PTP prevented endogenous UBPY from associating with EGFR, consistent with increased EGFR ubiquitination."
23477725