IndraLab

Statements

CHEK2 affects USP28
| 6 8
CHEK2 binds USP28.
| 4 7
USP28 binds CHEK2. 5 / 5
| 4 1
sparser
"It was previously shown that USP28 interacts with CHK2 [ xref ]."
| PMC
reach
"USP28 forms a complex with PIRH2 and CHK2 and antagonizes PIRH2 mediated polyubiquitylation and proteasomal degradation of CHK2 [XREF_BIBR]."
28031783
reach
"Similar to FBXW7, USP28 forms a complex with PIRH2 and CHK2, thus antagonizing the ubiquitination of CHK2 by PIRH2.The protein PIRH2 (also called RCHY1) is a promising candidate for maintaining the previously demonstrated USP28 “piggyback” model."
| PMC
reach
"We show that the deubiquitylating enzyme USP28 forms a complex with PIRH2 and CHK2 and antagonizes PIRH2 mediated polyubiquitylation and proteasomal degradation of CHK2."
23449389
reach
"USP28 forms a complex with PIRH2 and CHK2 and counteracts the negative regulation of PIRH2 on CHK2 21."
29415985
USP28 binds CHEK2 and RCHY1. 5 / 5
| 5
sparser
"Similar to FBXW7, USP28 forms a complex with PIRH2 and CHK2, thus antagonizing the ubiquitination of CHK2 by PIRH2."
| PMC
sparser
"We show that the deubiquitylating enzyme USP28 forms a complex with PIRH2 and CHK2 and antagonizes PIRH2-mediated polyubiquitylation and proteasomal degradation of CHK2."
23449389
sparser
"USP28 forms a complex with PIRH2 and CHK2 and counteracts the negative regulation of PIRH2 on CHK221."
29415985
sparser
"USP28 forms a complex with PIRH2 and CHK2 and antagonizes PIRH2-mediated polyubiquitylation and proteasomal degradation of CHK2 [ xref ]."
28031783
sparser
"USP28 forms a complex with PIRH2 and CHK2 and counteracts the negative regulation of PIRH2 on CHK2 xref ."
29415985
E3_Ub_ligase binds TP53, USP28, CHEK2, and MYC. 1 / 1
| 1
sparser
"Another potential candidate is UBR5, an E3 ligase that interacts with several reported USP28 substrates such as CHK2, p53, and c-MYC [ xref , xref , xref , xref ]."
| PMC
CHEK2 phosphorylates USP28.
| 2 1
CHEK2 phosphorylates USP28. 3 / 3
| 2 1
reach
"However, analyses of the USP28 sequence did not reveal any CHK2 phosphorylation motif, suggesting that USP28 cannot be phosphorylated by CHK2."
| PMC
sparser
"However, analyses of the USP28 sequence did not reveal any CHK2 phosphorylation motif, suggesting that USP28 cannot be phosphorylated by CHK2."
| PMC
reach
"The downstream ATM kinase CHK2 could be a potential candidate to phosphorylates USP28 following DNA damage."
| PMC
USP28 affects CHEK2
1 | 5 7
USP28 binds CHEK2.
| 4 7
USP28 binds CHEK2. 5 / 5
| 4 1
sparser
"It was previously shown that USP28 interacts with CHK2 [ xref ]."
| PMC
reach
"USP28 forms a complex with PIRH2 and CHK2 and antagonizes PIRH2 mediated polyubiquitylation and proteasomal degradation of CHK2 [XREF_BIBR]."
28031783
reach
"Similar to FBXW7, USP28 forms a complex with PIRH2 and CHK2, thus antagonizing the ubiquitination of CHK2 by PIRH2.The protein PIRH2 (also called RCHY1) is a promising candidate for maintaining the previously demonstrated USP28 “piggyback” model."
| PMC
reach
"We show that the deubiquitylating enzyme USP28 forms a complex with PIRH2 and CHK2 and antagonizes PIRH2 mediated polyubiquitylation and proteasomal degradation of CHK2."
23449389
reach
"USP28 forms a complex with PIRH2 and CHK2 and counteracts the negative regulation of PIRH2 on CHK2 21."
29415985
USP28 binds CHEK2 and RCHY1. 5 / 5
| 5
sparser
"Similar to FBXW7, USP28 forms a complex with PIRH2 and CHK2, thus antagonizing the ubiquitination of CHK2 by PIRH2."
| PMC
sparser
"We show that the deubiquitylating enzyme USP28 forms a complex with PIRH2 and CHK2 and antagonizes PIRH2-mediated polyubiquitylation and proteasomal degradation of CHK2."
23449389
sparser
"USP28 forms a complex with PIRH2 and CHK2 and counteracts the negative regulation of PIRH2 on CHK221."
29415985
sparser
"USP28 forms a complex with PIRH2 and CHK2 and antagonizes PIRH2-mediated polyubiquitylation and proteasomal degradation of CHK2 [ xref ]."
28031783
sparser
"USP28 forms a complex with PIRH2 and CHK2 and counteracts the negative regulation of PIRH2 on CHK2 xref ."
29415985
E3_Ub_ligase binds TP53, USP28, CHEK2, and MYC. 1 / 1
| 1
sparser
"Another potential candidate is UBR5, an E3 ligase that interacts with several reported USP28 substrates such as CHK2, p53, and c-MYC [ xref , xref , xref , xref ]."
| PMC
USP28 deubiquitinates CHEK2.
1 |
USP28 deubiquitinates CHEK2. 1 / 1
1 |
USP28 activates CHEK2.
| 1
USP28 activates CHEK2. 1 / 1
| 1
reach
"Interestingly, in another study, CHK2 is shown to be directly regulated by USP28."
29415985