IndraLab

Statements

USP28 activates CDKN1A.
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USP28 activates CDKN1A. 3 / 3
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"Consistent with the notion that deubiquitination of ub-K119-H2A leads to transcriptional activation, we showed that depletion of USP28 inhibits the transcriptional activity of p53, p21 and p16 INK4a ."
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"We showed that 53BP1 and USP28 are required to trigger p53 and p21- dependent cell cycle arrest, evoking an irreversible stress response that selects against unfit cells with disturbed mitosis (XREF_FIG)."
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"USP28 overexpression increased the levels of multiple senescence markers, including p53, p21 , and GATA4 proteins but not p16, again suggesting that USP28 may be inducing senescence in part through the p53 and GATA4 branches (Fig. 3C–E; Supplemental Fig. S3K,L)."
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Mutated USP28 activates CDKN1A. 1 / 1
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"Consistent with this, the expression of WT or ubiquitin binding mutant USP28 rescued p21 and MDM2 induction defects in USP28Delta cells, whereas expression of USP28 C171A did not (XREF_SUPPLEMENTARY B)."
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USP28 increases the amount of CDKN1A.
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USP28 increases the amount of CDKN1A. 2 / 2
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"Furthermore, USP28 depletion reduced levels of basal and nutlin-3a-induced p21 expression (Fig. 2F), suggesting that USP28 may also affect p21 levels during replicative senescence, likely through p53."
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"Consistent with the lower expression of p53, p21 and p16, USP28-depleted 2BS cells had less blue-colored cells ( Fig. 6 C), and the numbers of senescence-positive cells in USP28 knockdown cells were a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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USP28 binds CDKN1A.
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CDKN1A binds TP53, TP53BP1, and USP28. 1 / 1
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"Important future directions include dissecting the interactions between 53BP1 and USP28 that activate downstream p53-p21 signaling, as well as screening for the upstream components that transduce the signal (see xref )."
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