IndraLab

Statements

USP28 binds CDKN1A.
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TP53 binds TP53BP1, USP28, and CDKN1A. 2 / 2
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sparser
"Important future directions include dissecting the interactions between 53BP1 and USP28 that activate downstream p53–p21 signaling as well as screening for the upstream components that transduce the s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28188027
sparser
"Important future directions include dissecting the interactions between 53BP1 and USP28 that activate downstream p53-p21 signaling, as well as screening for the upstream components that transduce the signal (see xref )."
28188027
USP28 activates CDKN1A.
| 2
Mutated USP28 activates CDKN1A. 1 / 1
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reach
"Consistent with this, the expression of WT or ubiquitin binding mutant USP28 rescued p21 and MDM2 induction defects in USP28Delta cells, whereas expression of USP28 C171A did not (XREF_SUPPLEMENTARY B)."
27546791
USP28 activates CDKN1A. 1 / 1
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reach
"We showed that 53BP1 and USP28 are required to trigger p53 and p21- dependent cell cycle arrest, evoking an irreversible stress response that selects against unfit cells with disturbed mitosis (XREF_FIG)."
27371829
USP28 increases the amount of CDKN1A.
| 1
USP28 increases the amount of CDKN1A. 1 / 1
| 1
reach
"Notably, USP28 knockdown cells had decreased expression of p53, p21 and p16 INK4a, suggesting that the effect of USP28 on cell proliferation was mediated by regulating the expression of p53, p21 and p16 INK4a."
30910399