IndraLab

Statements

ATM affects USP28
4 | 10 6
ATM phosphorylates USP28.
4 | 8 6
ATM phosphorylates USP28. 10 / 11
| 5 6
sparser
"These novel findings establish a direct connection between the ubiquitination of UCK1 by KLHL2 and phosphorylation of USP28 and UCK1 by ATM, which are involved in mediating drug resistance against 5'-AZA in AML patients."
31938050
sparser
"In response to DNA damage, phosphorylation of the deubiquitinase USP28 by DDR kinases, ATM, and ATR leads to deubiquitination of either GATA4 or its associated factor [ xref ]."
33557090
reach
"In response to 5 '-AZA, UCK1 and USP28 are phosphorylated by ATM, instigating entirely different effects on the protein protein interaction."
31938050
reach
"The downstream ATM kinase CHK2 could be a potential candidate to phosphorylates USP28 following DNA damage."
| PMC
sparser
"Once all the three conservative SQ sites (S67, S495, and S714), in USP28, were mutated to alanine, the pS/TQ antibody completely could not recognize the immunoprecipitated Flag-USP28-3S/A (Figure xref D), suggesting that in response to 5'-AZA-induced stress, ATM phosphorylates USP28 at all these three sites."
31938050
sparser
"We next asked whether ATM or ATR phosphorylates USP28 upon CPPD treatment."
34611298
sparser
"In response to 5'-AZA, UCK1 and USP28 are phosphorylated by ATM, instigating entirely different effects on the protein-protein interaction."
31938050
reach
"USP28 is also phosphorylated by ATR and ATM and is involved in the response to DNA damage by virtue of its ability to deubiquitinate and stabilize FBW7 (see below), the ubiquitin ligase involved in the degradation of the myc transcription factor."
19489724
sparser
"It cannot be excluded the possibility that kinases other than ATM could phosphorylate USP28 under DNA damage stress."
| PMC
reach
"In response to DNA damage, phosphorylation of the deubiquitinase USP28 by DDR kinases, ATM, and ATR leads to deubiquitination of either GATA4 or its associated factor [XREF_BIBR]."
33557090
ATM phosphorylates USP28 on S714. 2 / 2
1 | 1
biopax:phosphositeplus
No evidence text available
reach
"Upon DNA damage, the phosphorylation of USP28 on serine 67 and serine 714 by the kinase ATM increases its enzymatic activity [10]."
| PMC
ATM phosphorylates USP28 on S495. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
ATM phosphorylates USP28 at position 67. 1 / 1
| 1
reach
"Upon DNA damage, the phosphorylation of USP28 on serine 67 and serine 714 by the kinase ATM increases its enzymatic activity [10]."
| PMC
ATM phosphorylates USP28 on S67. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
ATM phosphorylates USP28 on serine. 1 / 1
| 1
reach
"Upon DNA damage, the phosphorylation of USP28 on serine 67 and serine 714 by the kinase ATM increases its enzymatic activity [10]."
| PMC
ATM phosphorylates USP28 on S720. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
ATM binds USP28.
| 1
USP28 binds ATM. 1 / 1
| 1
reach
"The USP25 activity may not be affected upon exposure to an inhibitor blocking the phosphorylation of USP28 on serine 67 and serine It could be another therapeutic option to target the binding between ATM and USP28 and reduce the phosphorylation of USP28, thus decreasing its enzymatic activity in cancer cells with increased DNA damage levels."
| PMC
ATM activates USP28.
| 1
ATM activates USP28. 1 / 1
| 1
reach
"Since 5 '-AZA treatment can activate ATM in AML cells and the ATM pathway can prevent the apoptosis induction in 5 '-AZA resistant cells XREF_BIBR, we sought to determine whether ATM modulated the effect of USP28 on the UCK1 deubiquitination in response to 5 '-AZA."
31938050
USP28 affects ATM
| 3
USP28 deubiquitinates ATM.
| 1
USP28 deubiquitinates ATM. 1 / 1
| 1
reach
"Mechanistically, USP28 deubiquitinates and stabilizes the specificity factors and mediators of ATM and ATR signaling by protecting them from ubiquitination-mediated proteasome degradation."
29415985
USP28 binds ATM.
| 1
USP28 binds ATM. 1 / 1
| 1
reach
"The USP25 activity may not be affected upon exposure to an inhibitor blocking the phosphorylation of USP28 on serine 67 and serine It could be another therapeutic option to target the binding between ATM and USP28 and reduce the phosphorylation of USP28, thus decreasing its enzymatic activity in cancer cells with increased DNA damage levels."
| PMC
USP28 activates ATM.
| 1
USP28 activates ATM. 1 / 1
| 1
reach
"This early disassembly of the MRN complex could be prevented by altering the ubiquitination site of Nbs1 or by expressing a deubiquitinase, Usp28, which sufficiently restored homologous recombination repair and ATM, a major checkpoint kinase against DNA DSBs, activation abilities in RTS and RecQL4-depleted cells."
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