IndraLab

Statements

TNFAIP3 affects IRAK1
1 | 3
TNFAIP3 binds IRAK1.
1 | 2
TNFAIP3 binds IRAK1. 3 / 3
1 | 2
sparser
"To determine whether the up-regulation of A20 was associated with the down-regulation of IRAK1, HMC cells were transfected with A20, and IRAK1 protein levels were detected in three mock-transfected and three A20 over-expression clones."
26648169
biogrid
No evidence text available
21220427
sparser
"Thus, deficient LPS-induced activation of IRAK4 and TAK1, K63-linked polyubiquitination of IRAK1 and TRAF6, and disrupted IRAK1-TRAF6 and IRAK1-IKKγ assembly associated with increased A20 expression and A20-IRAK1 interactions are new determinants of endotoxin tolerance."
21220427
TNFAIP3 ubiquitinates IRAK1.
| 1
TNFAIP3 ubiquitinates IRAK1. 1 / 1
| 1
sparser
"Because TRAF6 E3 ligase activity is dependent on Ubc13 and UbcH5 for generating free polyubiquitin chains or ubiquitinating the regulatory kinase IRAK1 [ xref , xref ], A20 targeting to ubiquitinated TRAF6 may be essential to disrupt TRAF6/Ubc13/UbcH5 interactions and thereby terminate NF-κB signaling."
21111841
sparser
"Immune system pathway genes, such as HLA,CRF4, PTPN22, TBX21, STAT4, IRF4,IRF5, CD247, BANK1, BLK, IRAK1, FOXP3 and TNFAIP3 are commonly associated with several autoimmune diseases (e.g. rheumatoid arthritis, Coeliac disease, type I diabetes, psoriasis, Crohn’s disease and systemic sclerosis) [ xref ]."
28785422