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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TNFAIP3 ubiquitinates IRAK1. 1 / 1

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"Because TRAF6 E3 ligase activity is dependent on Ubc13 and UbcH5 for generating free polyubiquitin chains or ubiquitinating the regulatory kinase IRAK1 [ xref , xref ], A20 targeting to ubiquitinated TRAF6 may be essential to disrupt TRAF6/Ubc13/UbcH5 interactions and thereby terminate NF-κB signaling."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...