IndraLab

Statements

COPS4 affects COPS5
13 4 | 2 10
COPS4 binds COPS5.
13 4 | 10
COPS4 binds COPS5. 10 / 21
13 4 | 4
biogrid
No evidence text available
19295130
biogrid
No evidence text available
28514442
biogrid
No evidence text available
16624822
biogrid
No evidence text available
19295130
hprd
No evidence text available
11337588
biogrid
No evidence text available
18850735
sparser
"Null mutants generated in this study are larval lethal, showing phenotypes associated with mutations in either CSN4 (molting defects) or CSN5 (melanotic tumors)."
18298797
biogrid
No evidence text available
22863883
hprd
No evidence text available
9707402
sparser
"NEDD8 is erased by the metalloprotease activity of a subunit COP9 signalosome-COPS5, thereby suppressing the CRLs [ xref ]."
32071713
COPS4 binds COPS5 and CSN2. 1 / 1
| 1
sparser
"Immunoprecipitation experiments using the antibody directed against Int-6, followed by immunoblot with the anti-Myc antibody, showed no binding of this protein to CSN2, CSN5, and CSN4 ( Fig. 2A [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12220626
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
COPS4 binds COPS3, COPS5, and COPS2. 1 / 1
| 1
sparser
"Among these proteins, JAB1, COPS2, COPS3, COPS4 and COPS7A are members of the CSN complex; xref therefore, interactions of pJAB1 with COPS2, COPS3 and COPS4 are easy to understand and may be involved in multiple functions of the CSN complex."
24091666
COPS4 binds COPS5 and CSN3. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
COPS4 binds SOCS3 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
COPS4 binds COPS5, GPS1, and CSN2. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS4 increases the amount of COPS5.
| 1
COPS4 increases the amount of COPS5. 1 / 1
| 1
reach
"Our data further showed that CSN4 silencing decreased CSN5 protein levels and suggest that the CSN4 effects on sGCalpha1 and p53 proteins are mediated by CSN5."
24725084
COPS4 activates COPS5.
| 1
COPS4 activates COPS5. 1 / 1
| 1
reach
"Interaction of the complex with a NEDDylated CRL leads to a series of conformational change events in Csn2, Csn4 and Csn7, triggering rearrangements in the Csn5 and Csn6 dimer, resulting in Csn5 activation by priming the Csn5 JAMM and MPN + motif for deNEDDylation [XREF_BIBR, XREF_BIBR]."
33099217
COPS5 affects COPS4
13 4 | 1 10
COPS5 binds COPS4.
13 4 | 10
COPS4 binds COPS5. 10 / 21
13 4 | 4
biogrid
No evidence text available
19295130
biogrid
No evidence text available
28514442
biogrid
No evidence text available
16624822
biogrid
No evidence text available
19295130
hprd
No evidence text available
11337588
biogrid
No evidence text available
18850735
sparser
"Null mutants generated in this study are larval lethal, showing phenotypes associated with mutations in either CSN4 (molting defects) or CSN5 (melanotic tumors)."
18298797
biogrid
No evidence text available
22863883
hprd
No evidence text available
9707402
sparser
"NEDD8 is erased by the metalloprotease activity of a subunit COP9 signalosome-COPS5, thereby suppressing the CRLs [ xref ]."
32071713
COPS4 binds COPS5 and CSN2. 1 / 1
| 1
sparser
"Immunoprecipitation experiments using the antibody directed against Int-6, followed by immunoblot with the anti-Myc antibody, showed no binding of this protein to CSN2, CSN5, and CSN4 ( Fig. 2A [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12220626
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
COPS4 binds COPS3, COPS5, and COPS2. 1 / 1
| 1
sparser
"Among these proteins, JAB1, COPS2, COPS3, COPS4 and COPS7A are members of the CSN complex; xref therefore, interactions of pJAB1 with COPS2, COPS3 and COPS4 are easy to understand and may be involved in multiple functions of the CSN complex."
24091666
COPS4 binds COPS5 and CSN3. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
COPS4 binds SOCS3 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
COPS4 binds COPS5, GPS1, and CSN2. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS5 activates COPS4.
| 1
COPS5 activates COPS4. 1 / 1
| 1
reach
"Our data further showed that CSN4 silencing decreased CSN5 protein levels and suggest that the CSN4 effects on sGCalpha1 and p53 proteins are mediated by CSN5."
24725084
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, and GPS1
2 |
hprd
No evidence text available
9535219
hprd
No evidence text available
12220626
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
SOCS3 affects COPS5
| 1
COPS4 binds SOCS3 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
GPS1 affects CSN2
| 1
COPS4 binds COPS5, GPS1, and CSN2. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
CSN3 affects COPS5
| 1
COPS4 binds COPS5 and CSN3. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
CSN2 affects GPS1
| 1
COPS4 binds COPS5, GPS1, and CSN2. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
COPS5 affects SOCS3
| 1
COPS4 binds SOCS3 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
COPS5 affects GPS1
| 1
COPS4 binds COPS5, GPS1, and CSN2. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS5 affects CSN3
| 1
COPS4 binds COPS5 and CSN3. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
COPS5 affects COPS3
| 1
COPS4 binds COPS3, COPS5, and COPS2. 1 / 1
| 1
sparser
"Among these proteins, JAB1, COPS2, COPS3, COPS4 and COPS7A are members of the CSN complex; xref therefore, interactions of pJAB1 with COPS2, COPS3 and COPS4 are easy to understand and may be involved in multiple functions of the CSN complex."
24091666
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
COPS4 affects SOCS3
| 1
COPS4 binds SOCS3 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
COPS4 affects GPS1
| 1
COPS4 binds COPS5, GPS1, and CSN2. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS4 affects CSN3
| 1
COPS4 binds COPS5 and CSN3. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
COPS4 affects COPS5, and isopeptidase activity
| 1
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
COPS4 affects COPS5, and SOCS3
| 1
COPS4 binds SOCS3 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
COPS4 affects COPS5, and CSN3
| 1
COPS4 binds COPS5 and CSN3. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
COPS4 affects COPS5, CSN2, and GPS1
| 1
COPS4 binds COPS5, GPS1, and CSN2. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS4 affects COPS5, and CSN2
| 1
COPS4 binds COPS5 and CSN2. 1 / 1
| 1
sparser
"Immunoprecipitation experiments using the antibody directed against Int-6, followed by immunoblot with the anti-Myc antibody, showed no binding of this protein to CSN2, CSN5, and CSN4 ( Fig. 2A [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12220626
COPS4 affects COPS3
| 1
COPS4 binds COPS3, COPS5, and COPS2. 1 / 1
| 1
sparser
"Among these proteins, JAB1, COPS2, COPS3, COPS4 and COPS7A are members of the CSN complex; xref therefore, interactions of pJAB1 with COPS2, COPS3 and COPS4 are easy to understand and may be involved in multiple functions of the CSN complex."
24091666
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, GPS1, and TP53
1 |
TP53 binds COPS4, COPS7A, COPS6, COPS3, COPS5, COPS8, COPS2, and GPS1. 1 / 1
1 |
hprd
No evidence text available
11285227
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, CUL4A, and GPS1
1 |
hprd
No evidence text available
11337588
hprd
No evidence text available
11337588
SKP1 binds FBXO3, FBXO6, COPS4, COPS7A, COPS7B, COPS6, COPS3, COPS5, COPS8, CUL1, COPS2, EEF2, GPS1, and RBX1. 1 / 1
1 |
hprd
No evidence text available
11337588
COPS2 affects COPS3, COPS4, and COPS5
| 1
COPS4 binds COPS3, COPS5, and COPS2. 1 / 1
| 1
sparser
"Among these proteins, JAB1, COPS2, COPS3, COPS4 and COPS7A are members of the CSN complex; xref therefore, interactions of pJAB1 with COPS2, COPS3 and COPS4 are easy to understand and may be involved in multiple functions of the CSN complex."
24091666