IndraLab

Statements

COPS4 affects COPS5
18 4 | 3 10
COPS4 binds COPS5.
18 4 | 10
COPS5 binds COPS4. 10 / 26
18 4 | 4
biogrid
No evidence text available
19295130
biogrid
No evidence text available
31950832
biogrid
No evidence text available
21145461
biogrid
No evidence text available
22863883
sparser
"These interactions prompted Azevedo et al. [36 •• ] to test SGT1b for interaction with CSN4 and CSN5, two components of the COP9 (constitutive photomorphogenesis 9) signaloso[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12495728
biogrid
No evidence text available
19615732
biogrid
No evidence text available
32034103
biogrid
No evidence text available
26186194
biogrid
No evidence text available
32034103
biogrid
No evidence text available
24725084
CSN2 binds COPS5 and COPS4. 1 / 1
| 1
sparser
"Immunoprecipitation experiments using the antibody directed against Int-6, followed by immunoblot with the anti-Myc antibody, showed no binding of this protein to CSN2, CSN5, and CSN4 ( Fig. 2A [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12220626
COPS5 binds COPS4 and GO:0070122. 1 / 1
| 1
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
COPS2 binds COPS3, COPS4, and COPS5. 1 / 1
| 1
sparser
"Among these proteins, JAB1, COPS2, COPS3, COPS4 and COPS7A are members of the CSN complex; xref therefore, interactions of pJAB1 with COPS2, COPS3 and COPS4 are easy to understand and may be involved in multiple functions of the CSN complex."
24091666
CSN3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
SOCS3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
GPS1 binds CSN2, COPS4, and COPS5. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS4 activates COPS5.
| 2
COPS4 activates COPS5. 2 / 2
| 2
reach
"Interaction of the complex with a NEDDylated CRL leads to a series of conformational change events in Csn2, Csn4 and Csn7, triggering rearrangements in the Csn5 and Csn6 dimer, resulting in Csn5 activation by priming the Csn5 JAMM and MPN + motif for deNEDDylation [XREF_BIBR, XREF_BIBR]."
33099217
reach
"In the presence of CRL4A, conformational changes in CSN2, CSN4, and CSN7 affect the CSN5-CSN6 dimer and activate CSN5."
39600336
COPS4 increases the amount of COPS5.
| 1
COPS4 increases the amount of COPS5. 1 / 1
| 1
reach
"Our data further showed that CSN4 silencing decreased CSN5 protein levels and suggest that the CSN4 effects on sGCalpha1 and p53 proteins are mediated by CSN5."
24725084
COPS5 affects COPS4
18 4 | 1 10
COPS5 binds COPS4.
18 4 | 10
COPS5 binds COPS4. 10 / 26
18 4 | 4
biogrid
No evidence text available
19295130
biogrid
No evidence text available
31950832
biogrid
No evidence text available
21145461
biogrid
No evidence text available
22863883
sparser
"These interactions prompted Azevedo et al. [36 •• ] to test SGT1b for interaction with CSN4 and CSN5, two components of the COP9 (constitutive photomorphogenesis 9) signaloso[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12495728
biogrid
No evidence text available
19615732
biogrid
No evidence text available
32034103
biogrid
No evidence text available
26186194
biogrid
No evidence text available
32034103
biogrid
No evidence text available
24725084
CSN2 binds COPS5 and COPS4. 1 / 1
| 1
sparser
"Immunoprecipitation experiments using the antibody directed against Int-6, followed by immunoblot with the anti-Myc antibody, showed no binding of this protein to CSN2, CSN5, and CSN4 ( Fig. 2A [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12220626
COPS5 binds COPS4 and GO:0070122. 1 / 1
| 1
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
COPS2 binds COPS3, COPS4, and COPS5. 1 / 1
| 1
sparser
"Among these proteins, JAB1, COPS2, COPS3, COPS4 and COPS7A are members of the CSN complex; xref therefore, interactions of pJAB1 with COPS2, COPS3 and COPS4 are easy to understand and may be involved in multiple functions of the CSN complex."
24091666
CSN3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
SOCS3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
GPS1 binds CSN2, COPS4, and COPS5. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS5 activates COPS4.
| 1
COPS5 activates COPS4. 1 / 1
| 1
reach
"Our data further showed that CSN4 silencing decreased CSN5 protein levels and suggest that the CSN4 effects on sGCalpha1 and p53 proteins are mediated by CSN5."
24725084
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, and GPS1
1 2 |
signor
"Inferred from SIGNOR complex SIGNOR-C489"
hprd
No evidence text available
12220626
hprd
No evidence text available
9535219
CSN2 affects COPS5
| 2
CSN2 binds COPS5 and COPS4. 1 / 1
| 1
sparser
"Immunoprecipitation experiments using the antibody directed against Int-6, followed by immunoblot with the anti-Myc antibody, showed no binding of this protein to CSN2, CSN5, and CSN4 ( Fig. 2A [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12220626
GPS1 binds CSN2, COPS4, and COPS5. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
SOCS3 affects COPS5
| 1
SOCS3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
GPS1 affects CSN2
| 1
GPS1 binds CSN2, COPS4, and COPS5. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
GO:0070122 affects COPS5
| 1
COPS5 binds COPS4 and GO:0070122. 1 / 1
| 1
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
CSN3 affects COPS5
| 1
CSN3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
CSN2 affects GPS1
| 1
GPS1 binds CSN2, COPS4, and COPS5. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS5 affects SOCS3
| 1
SOCS3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
COPS5 affects GPS1
| 1
GPS1 binds CSN2, COPS4, and COPS5. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS5 affects GO:0070122
| 1
COPS5 binds COPS4 and GO:0070122. 1 / 1
| 1
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
COPS5 affects CSN3
| 1
CSN3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
COPS5 affects COPS3
| 1
COPS2 binds COPS3, COPS4, and COPS5. 1 / 1
| 1
sparser
"Among these proteins, JAB1, COPS2, COPS3, COPS4 and COPS7A are members of the CSN complex; xref therefore, interactions of pJAB1 with COPS2, COPS3 and COPS4 are easy to understand and may be involved in multiple functions of the CSN complex."
24091666
COPS4 affects SOCS3
| 1
SOCS3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
COPS4 affects GPS1
| 1
GPS1 binds CSN2, COPS4, and COPS5. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS4 affects GO:0070122
| 1
COPS5 binds COPS4 and GO:0070122. 1 / 1
| 1
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
COPS4 affects CSN3
| 1
CSN3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
COPS4 affects COPS5, and SOCS3
| 1
SOCS3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Furthermore, we also found that knockdown of CSN3 not only obviously inhibited OGD/R-induced upregulation of SOCS3 protein in microglia but also decreased SOCS3 interacting with CSN4 and CSN5 ( xref )."
33911869
COPS4 affects COPS5, and GO:0070122
| 1
COPS5 binds COPS4 and GO:0070122. 1 / 1
| 1
sparser
"The transforming effects of CSN5 require CSN subunits for assembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the transcriptional activity of MYC."
18199546
COPS4 affects COPS5, and CSN3
| 1
CSN3 binds COPS4 and COPS5. 1 / 1
| 1
sparser
"Among the novel interactions, Rho1 showed negative interactions with CSN3, CSN4 and CSN5 (CSN3-5)."
21849035
COPS4 affects COPS5, CSN2, and GPS1
| 1
GPS1 binds CSN2, COPS4, and COPS5. 1 / 1
| 1
sparser
"Removal of either one of the four CSN subunits in transfection experiments greatly reduced co-precipitation of FLAG-CUL1 (lanes 3–6), suggesting that CSN1, CSN2, CSN4, and CSN5 could form a minimal co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16036220
COPS4 affects COPS5, and CSN2
| 1
CSN2 binds COPS5 and COPS4. 1 / 1
| 1
sparser
"Immunoprecipitation experiments using the antibody directed against Int-6, followed by immunoblot with the anti-Myc antibody, showed no binding of this protein to CSN2, CSN5, and CSN4 ( Fig. 2A [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12220626
COPS4 affects COPS3
| 1
COPS2 binds COPS3, COPS4, and COPS5. 1 / 1
| 1
sparser
"Among these proteins, JAB1, COPS2, COPS3, COPS4 and COPS7A are members of the CSN complex; xref therefore, interactions of pJAB1 with COPS2, COPS3 and COPS4 are easy to understand and may be involved in multiple functions of the CSN complex."
24091666
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7B, COPS8, and GPS1
1 |
COPS2 binds GPS1, COPS6, COPS5, COPS8, COPS4, COPS7B, and COPS3. 1 / 1
1 |
signor
"Inferred from SIGNOR complex SIGNOR-C487"
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, GPS1, and TP53
1 |
TP53 binds COPS2, COPS5, COPS3, COPS4, GPS1, COPS6, COPS7A, and COPS8. 1 / 1
1 |
hprd
No evidence text available
11285227
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, CUL4A, and GPS1
1 |
hprd
No evidence text available
11337588
hprd
No evidence text available
11337588
EEF2 binds SKP1, CUL1, COPS2, RBX1, COPS5, COPS3, FBXO6, COPS4, COPS7B, GPS1, FBXO3, COPS6, COPS7A, and COPS8. 1 / 1
1 |
hprd
No evidence text available
11337588
COPS2 affects COPS3, COPS4, and COPS5
| 1
COPS2 binds COPS3, COPS4, and COPS5. 1 / 1
| 1
sparser
"Among these proteins, JAB1, COPS2, COPS3, COPS4 and COPS7A are members of the CSN complex; xref therefore, interactions of pJAB1 with COPS2, COPS3 and COPS4 are easy to understand and may be involved in multiple functions of the CSN complex."
24091666