IndraLab

Statements

GDNF binds GFRA1. 10 / 302
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"The two receptors also interact with low affinity in the absence of ligand, resulting in the formation of a less selective receptor complex capable of interacting with other members of the GDNF ligand[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, proximal events in RET independent GDNF signaling in RN33B and Schwann cells resemble the intracellular pathways activated by p140 NCAM, both in its time course and in the types of molecules inv[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12837245
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"SORLA facilitates internalization of GFRalpha1 and GDNF complexes from the plasma membrane, resulting in lysosomal catabolism of GDNF but cell surface recycling of GFRalpha1."
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"With a lower affinity, the GDNF–GFRα1 complex can signal via the RET-independent mechanism with the neural cell adhesion molecule (NCAM); GDNF can also signal independently from GFRα1 by interacting with the heparin sulfate proteoglycan syndecan-3 [ xref , xref ]."
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"For UB outgrowth, MM cells secrete GDNF which binds to the RET tyrosine kinase receptor and co-receptor GFRa1, both expressed in the nephric duct [ xref , xref , xref ]."
30974877
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"GDNF dimers bind preferentially to GFRα1 with high affinity."
31456664
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"GDNF is expressed by the mesenchymal tissue surrounding the growing ureteric bud and binds to the tyrosine kinase receptor Ret and its co-receptor Gfra1, a glycosyl-phosphatidyl inositol linked protein."
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"Here, we find that SorLA acts as sorting receptor for the GDNF and GFRalpha1 complex, directing it from the cell surface to endosomes."
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"As shown in XREF_FIG, GFRA1 directly interacts with GDNF and alternatively, it can bind ARTN or NRTN; GFRA2 binds with NRTN; GFRA3 interacts with ARTN; and GFRA4 is the preferential co-receptor for PSPN."
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"GDNF has been shown to display greater affinity for GFRalpha1b than it does for GFRalpha1a and, as a result, GDNF and GFRalpha1 complexes are more likely to lead to RET phosphorylation at lower ligand concentrations."
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GDNF binds GFRA1 and RET. 10 / 29
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"In support of this idea, coimmunoprecipitation assays reveal constitutive binding between N-CAM and GFRα1, which is in significant contrast to the GFRα1-RET interaction that requires GDNF binding (Ta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12837237
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"Examples of such associations between GPI-anchored proteins and transmembrane signaling partners in neurons include the transmembrane protein CASPR and the GPI-linked cell adhesion molecule contactin ( xref ) and binding of GDNF to the receptor complex formed by the GPI-anchored receptor GFRα1 and the transmembrane protein c-Ret ( xref , xref )."
18786358
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"Importantly, expression of FAT4 perturbs the assembly of the RET-GFRA1-GDNF complex, reducing RET signaling."
30853441
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"GDNF binding to its receptors RET and GFRα1 induces both ERK/MAPK and PI3K pathway activation."
27480037
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"Thus, without formation of the GDNF, RET, and GFRalpha1 complex, aganglionosis is observed, irrespective of whether the mutation is in RET, GDNF or Gfralpha1 [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
23528997
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"This finding is in accordance with RET deficient mice in which they displayed increased gliosis in the SN, suggesting the importance of the GDNF, GFRalpha1, and RET complex in the suppression of inflammation."
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"GDNF binds to the heteromeric GFRα1-Ret receptor complex, and the receptor complex then binds to and phosphorylates SHC."
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"The binding of GDNF to Ret and GFRα1 leads to Ret phosphorylation (Kjær and Ibáñez, 2003; Sariola and Saarma, 2003), and thereby leads to the activation of several intracellular signaling pathways, including RAS/mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (mTOR) pathway, which in turn promotes neuronal survival and differentiation (Creedon et al., 1997; Uesaka et al., 2013)."
25317167
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"Formation of the GDNF 2 –GFRA1 2 –RET 2 heterohexameric complex results in transphosphorylation of RET, thereby activating the receptor tyrosine kinase signaling pathway [ xref – xref ]."
29088765
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"The GDNF–GFRα1 complex then binds the RET [ xref , xref ] present on neuronal cell bodies and terminals of several different pathways, such as nigro–striatal dopaminergic neurons [ xref , xref ], spinal motor neurons [ xref ], noradrenergic neurons of the locus coeruleus [ xref ], enteric neurons [ xref ], and sensory neurons [ xref ]."
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GDNF binds GFRA1 and NCAM1. 6 / 6
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"The GDNF:GFRα1 complex is also able to bind to NCAM with high affinity to activate SFKs and FAK xref ."
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"In this last section, we turn our attention to some of the possible implications of the interactions between GDNF, GFRα1, and NCAM for development in vivo."
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"NCAM binds GFRα1 and GDNF and downregulates NCAM-mediated cell adhesion, which activates cytoplasmic protein tyrosine kinase signaling in the absence of RET."
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"GFRa1 and GDNF interact with NCAM in neurons and Schwann cells to promote neurite outgrowth and Schwann cell migration ( xref ; xref )."
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"Both proteins are coexpressed in the developing nephron, midbrain and motor neurons and mice carrying a disruption of either Ret or GFRα1 are deficient in renal and neuronal development and suffer from early postnatal death. xref GDNF/Ret signalling through the phosphatidylinositol 3-kinase/nuclear factor kappa B pathway is required for mitochondrial function and morphology, xref and seems also relevant for dopamine system maintenance to prevent Parkinson’s and Hirschsprung diseases. xref Besides, it has been reported that p140 NCAM may interact with GFRα1 to mediate GDNF signalling independently from Ret in Schwann cell migration. xref Another study also describes that GDNF can regulate migration of GABAergic cells in the medial ganglionic eminence and cortex via GFRα1, but not Ret or NCAM. xref Finally, an inverse relationship between GFRα1 and Ret has been reported in dopaminergic neurons, where knocking down Ret leads to increased GFRα1 expression. xref "
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"In addition to promoting high-affinity binding of GDNF ligands, the association of GFRα1 with NCAM prevented homophilic NCAM-NCAM interactions (Paratcha et al. xref ), illustrating the ability of GFRα1 to transform NCAM from a short-range cell adhesion molecule into a long-range signaling receptor for diffusible GDNF ligands."
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GDNF binds GFRA1 and NRTN. 2 / 2
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"While both GDNF and NTN bind GFRα1 and GFRα2, GDNF binds GFRα1 with more efficiency, and NTN binds GFRα2 preferentially ()."
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"Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2."
10829012
GDNF binds GFRA1, ARTN, and NRTN. 2 / 2
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"The ligand specificity is determined by a co-receptor subunit – GDNF, neurturin and artemin bind preferentially to GFRα1, GFRα2 and GFRα3 respectively [ xref ]."
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"Each family member binds a distinct GFRα family co-receptor, such that GDNF, NRTN and ARTN bind GFRα1, -α2, and -α3, respectively."
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"There are several possible reasons for the injury-induced increase of GDNF only in the rostral part of the spinal cord: (1) de novo synthesis of GDNF, (2) accumulation of GDNF being transported from rostral to caudal side of the spinal cord, (3) accumulation of GDNF being retrogradely transported within the peripheral nerves from the skeketal muscles to the motoneurons, (4) binding of GDNF to the injury-evoked GFRα1, coreceptor of GDNF, (5). supply of GDNF from the dorsal root ganglia (DRG)."
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"The neurotrophic activities of GDNF are mediated by binding to GFRalpha1 and further interaction of the GDNF-GFRalpha1 complex with a coreceptor tyrosine kinase encoded by the c-Ret protooncogene."
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GDNF binds GFRA1, ARTN, NRTN, and PSPN. 2 / 2
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"In addition, GDNF can also interact with GFRα2 and NRTN, ARTN and PSPN with GFRα1, although with a lower affinity than with the cognate coreceptors [ xref ]."
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"GDNF, NRTN, ARTN, and PSPN bind to GFRA1 (GDNF family receptor alpha-1), GFRA2 (GDNF family receptor alpha-2), GFRA3 (GDNF family receptor alpha-3), and GFRA4 (GDNF family receptor alpha-4), respectively ( xref )."
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"Glial cell line-Derived Neurotrophic Factor (GDNF) binds the GFRα1 receptor, and the GDNF-GFRα1 complex binds to and activates the transmembrane RET tyrosine kinase to signal through intracellular Akt/Erk pathways."
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"Normal budding of the UB from the WD is dependent on glial cell line derived neurotrophic factor (GDNF) interacting with its co-receptors Ret and GFRα1."
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GDNF binds GFRA1, GFRA2, NRTN, and RET. 1 / 1
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"GDNF and NRTN bind to the tyrosine kinase receptor Ret and the receptors GFRalpha1 and GFRalpha2."
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GDNF binds GFRA1, GFRA2, and NRTN. 1 / 1
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"Interaction of GFRalpha1 and GFRalpha2 with GDNF and neurturin required distinct subsegments within this central domain, which allowed the construction of chimeric receptors that responded equally well to both ligands."
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GDNF binds GFRA1 and cRET multi-subunit receptor. 1 / 1
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"Interestingly, the following week a Nature publication [XREF_BIBR] revealed concurrent work with similar findings on a cloned and characterized GFRalpha-1, as well as the GDNF, GFRalpha-1, and cRET multi-subunit receptor complex."
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GDNF binds GFRA1, RET, and 78-211. 1 / 1
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"4UX8 is electron microscopy structure of the GDNF, GFRA1, and RET complex with residues 78-211 of the D chain of GDNF [XREF_BIBR]."
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CTNNB1 binds GDNF, GFRA1, and RET. 1 / 1
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"However, molecular studies in human HEK293 and neuroblastoma cell lines demonstrated a GDNF/GFRα1-induced interaction between RET and β-catenin at the plasma membrane, resulting in tyrosine phosphorylation of β-catenin which prevents its proteasomal degradation, and results in cell survival and proliferation ( xref )."
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AKT binds ERK, GDNF, GFRA1, and RET. 1 / 1
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"GDNF binds GFRa1-RET, leading to the phosphorylation of the AKT and ERK pathways to regulate the proliferation and self-renewal of dairy goat SSCs."
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CRY1 binds GDNF, GFRA1, and RET. 1 / 1
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"These results contradict previous studies suggesting that mammalian GFRα1 and GDNF cannot bind and activate non-mammalian RET and vice versa ."
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GDNF binds GFRA1 and RetA. 1 / 1
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"Thus, their potential binding sites and interactions were explored in the GDNF, GFRalpha1, and RetA complex using molecular docking calculations as well as molecular dynamics (MD) simulations."
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GDNF binds GFRA1 and GFRA2. 1 / 1
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"GDNF can also bind to either GFRalpha-1 or GFRalpha-2, and activate Ret in the presence of either binding receptor."
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GDNF binds GFRA1 and MET. 1 / 1
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"Indeed, in MDCK cells and several other cell types, GDNF binding to GFRalpha1 activates Met indirectly via Src family kinases."
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TNFRSF1B binds GDNF, GFRA1, and RET. 1 / 1
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"In this study, we demonstrate that p75 forms a GDNF-activated receptor complex with GFRα1 and Ret."
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GDNF binds GFRA1 and TM. 1 / 1
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"GFRα1-TM still binds GDNF and promotes Ret activation but does not translocate into rafts."
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