IndraLab

Statements

sparser
"There are several possible reasons for the injury-induced increase of GDNF only in the rostral part of the spinal cord: (1) de novo synthesis of GDNF, (2) accumulation of GDNF being transported from rostral to caudal side of the spinal cord, (3) accumulation of GDNF being retrogradely transported within the peripheral nerves from the skeketal muscles to the motoneurons, (4) binding of GDNF to the injury-evoked GFRα1, coreceptor of GDNF, (5). supply of GDNF from the dorsal root ganglia (DRG)."
23202963
sparser
"The neurotrophic activities of GDNF are mediated by binding to GFRalpha1 and further interaction of the GDNF-GFRalpha1 complex with a coreceptor tyrosine kinase encoded by the c-Ret protooncogene."
12701883