IndraLab

Statements

OTUD4 increases the amount of Interferon. 2 / 2
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"[178] This is supported by the observation that knockout or knockdown of OTUD4 impairs the RNA virus triggered expression of type I interferon and enhances VSV replication, both in vitro and in vivo."
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"Therefore, OTUD4 could enhance type I IFN expression during HSV-1 infection, and this function appeared to be blocked by ICP0-dependent processes.After confirming that ICP0 was important for HSV-1 lytic infection in neuronal cells, we combined quantitative interactome and ubiquitinome approaches to identify targets of ICP0 followed by validation of the interaction and ubiquitination events in Neuro-2a cells."
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