IndraLab

Statements

RPS6KB1 phosphorylates RPS6 at position 244. 3 / 3
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"Its phosphorylation serves as a robust readout of mTORC1 activity, since rpS6 is phosphorylated at Serine 240 and 244 specifically by p70S6K, which is itself activated by direct phosphorylation of Thr389 by mTORC1 [24–26]."
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"Its phosphorylation serves as a robust readout of mTORC1 activity, since rpS6 is phosphorylated at Serine 240 and 244 specifically by p70S6K, which is itself activated by direct phosphorylation of Thr 389 by mTORC1 [24] [25] [26] ."
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"Ribosomal S6 kinase1 (S6K1), a downstream effector of mTORC1, phosphorylates ribosomal protein S6 at serine 235, 236, 240, 244 and 247 and the ratio of pS6 S235/236 / S6 was used as the functional marker of mTORC1 kinase activity 9."
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