IndraLab

Statements

UCHL1 increases the amount of reactive oxygen species. 5 / 5
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"We further showed that UCH-L1 increases ROS levels in HUVEC by deubiquitinating NOX4 in VEGF signaling."
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"Also, UCH-L1 is found to increase cellular ROS levels and promote cell invasion by up-regulating H 2 O 2 via deubiquitinating NOX4 [13]."
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"Silencing UCH-L1 decreased cellular ROS levels in HUVECs, and reduced angiogenesis."
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"UCHL1 is found to increase cellular ROS level by up-regulating H 2 O 2 generation in melanoma cells and induce apoptosis in spermatocyte of mice with cryptorchidism and breast tumour cells 54, 55, 56."
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"UCH-L1 was found to increase cellular ROS levels and promote cell invasion."
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