IndraLab

Statements


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reach
"An experimental structure of the KCNE1/KCNQ1/calmodulin complex has not been determined, so we examined multiple AI-based models (Fig. S11)."

reach
"We therefore overlaid mean missense trafficking and missense functional scores on the AlphaFold-multimer structural model of the KCNE1-KCNQ1-calmodulin complex (Fig. 5A–D)."

reach
"Although there is no solved cryo-EM structure of the KCNQ1-KCNE1-calmodulin complex, we used AlphaFold2 and homology modeling to construct a structural model of the I complex."

sparser
"CaM binds to the proximal C-terminus of KCNQ1 and is thought to compete with PIP 2 to stabilize the KCNQ1 open state; this also occurs in physiological relevant complexes in which KCNQ1-CaM co-assembles with the KCNE1 ancillary subunit to form I Ks complexes (see below) ( xref )."

sparser
"KCNE1 forms a ternary complex with wild-type KCNQ1 and Ca(2+)-CaM that prevents inactivation, facilitates channel assembly, and mediates a Ca(2+)-sensitive increase of IKS-current, with a considerable Ca(2+)-dependent left-shift of the voltage-dependence of activation."

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"Structural model of the KCNE1/KCNQ1/calmodulin complex."

reach
"An experimental structure of the KCNE1/KCNQ1/calmodulin complex has not been determined, so we examined multiple AI-based models (Figure S8)."

reach
"We therefore overlaid mean trafficking and functional scores on the AlphaFold-multimer structural model of the KCNE1-KCNQ1-calmodulin complex (Figure 5A–D)."

reach
"Although there is no solved cryo-EM structure of the KCNQ1-KCNE1-calmodulin complex, we used AlphaFold2 and homology modeling to construct a structural model of the I complex."

reach
"Structural model of the KCNE1/KCNQ1/calmodulin complex."