IndraLab

Statements

CALM binds KCNE1 and KCNQ1. 2 / 2
| 2
sparser
"KCNE1 forms a ternary complex with wild-type KCNQ1 and Ca(2+)-CaM that prevents inactivation, facilitates channel assembly, and mediates a Ca(2+)-sensitive increase of IKS-current, with a considerable Ca(2+)-dependent left-shift of the voltage-dependence of activation."
16556865
sparser
"CaM binds to the proximal C-terminus of KCNQ1 and is thought to compete with PIP 2 to stabilize the KCNQ1 open state; this also occurs in physiological relevant complexes in which KCNQ1-CaM co-assembles with the KCNE1 ancillary subunit to form I Ks complexes (see below) ( xref )."
32655402