IndraLab

Statements

ZUP1 inhibits CRC. 6 / 6
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"In the present study, we reported that DUb inhibited CRC growth by upregulating SIRT2."
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"Moreover, DUb inhibited CRC progression by upregulating SIRT2."
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"These data suggest that DUb inhibits CRC growth by impeding tumor cell proliferation.Given that DUb suppresses mouse-derived CRC growth, we speculated that DUb can also inhibit human-derived CRC growth by attenuating tumor cell proliferation."
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"Herein, we found that DUb significantly inhibited CRC growth in the patient-derived xenograft (PDX) and CT26 xenograft models."
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"These results show that DUb reduces CRC growth by suppressing tumor cell proliferation in vivo.To explore the effect of DUb on CRC cell proliferation, HCT116 and LoVo cells were treated with different concentrations of DUb for 96 h, and the cell viability was detected by the MTT assay."
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"Furthermore, the results of IHC staining against SIRT2 antibodies shows that SIRT2 expression in the DUb-treated xenograft tumor is significantly increased as compared with control.Given that DUb upregulated SIRT2 expression, we speculated that DUb inhibited CRC growth by upregulating SIRT2."
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