IndraLab

Statements

PKC inhibits KCNC4. 4 / 4
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sparser
"Kv3.4 channels help shape the repolarization of the nociceptor APs, and that modulation of Kv3.4 channel N-type inactivation by PKC regulates AP repolarization and duration suggesting that the dramatic modulation of high voltage-activated A-type K+ current ( I A HV ) fast inactivation by PKC represents a novel mechanism of neural plasticity with potentially significant implications in the transition from acute to chronic pain [ xref ]."
25027291
sparser
"Accordingly, we leveraged previous studies that demonstrated quick elimination of Kv3.4 fast inactivation by protein kinase C (PKC) – dependent phosphorylation of the channel’s N-terminal inactivation domain xref ."
38514618
reach
"In small-diameter dorsal root ganglion nociceptors, the activation of PKC substantially slowed the Kv3.4 channel inactivation, narrowed the action potential waveform, and accolated the action potential repolarization, showing that the influence of Kv3.4 channel conductance on the action potential waveform was enhanced (Ritter et al. 2012)."
38492001
sparser
"These results show that Kv3.4 channels help shape the repolarization of the nociceptor AP, and that modulation of Kv3.4 channel N-type inactivation by PKC regulates AP repolarization and duration."
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