IndraLab

Statements

TNF increases the amount of USP18. 7 / 9
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"TNF-alpha and LPS treatment also led to augmented USP18 protein expression by Western blotting (XREF_FIG) and by intracellular staining (XREF_FIG to XREF_FIG)."
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"IFN-alpha, LPS, and TNF-alpha do not induce type 1 and 2 IFNs in primary murine hepatocytes but do induce USP18 expression."
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"We suspect that whereas increased TNF-alpha does contribute to USP18 expression, there are other stimuli, for example, LPS and perhaps the recently described interferon-lambda 4, that also modulate hepatic USP18 expression."
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"MacParland et al. showed that TNF-alpha or LPS could target USP18 expression and thus inhibit IFN signaling [XREF_BIBR]."
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"USP18 mRNA expression was induced by TNF-alpha and LPS but not by IL-6 or IL-10 (XREF_FIG)."
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"Having shown that LPS and TNF-alpha stimulation increases hepatocyte USP18 expression, we then sought to determine whether we could pharmacologically inhibit the induction of USP18 by LPS and TNF-alpha."
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"We next sought to determine whether TNF-alpha and LPS could induce USP18 expression in hepatocytes via the induction of IFN-alpha."
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