IndraLab

Statements

OPTN binds CYLD. 28 / 28
5 | 7 16
sparser
"The interaction of CYLD with optineurin is essential for negative regulation of TNFα-induced NF-κB activation."
21408173
sparser
"Following virus infection, activation of the RIG/MAVS pathway leads to TBK1 activation (presumably through phosphorylation by an upstream unknown kinase and ubiquitination by the E3 ligases MIB1/2 or Ndrp1) and to the disruption of its interaction with Optn and CYLD."
25923723
reach
"Subsequent work has shown that OPTN interacts with the deubiquitinase CYLD, a negative regulator of NF-kappaB that deubiquitinates RIP."
29951055
sparser
"Here we have analysed the role of optineurin-CYLD interaction in the regulation of TNFα-induced NF-κB activation."
21408173
sparser
"Interestingly, Optn interacts with the tumor suppressor gene CYLD, a deubiquitinase (DUB) that catalyzes the cleavage of linear and K63-linked polyubiquitin chains and with A20, a DUB for K63-linked polyubiquitinated signaling mediators such as TRAF6 and RIP1 [ xref – xref ]."
25923723
reach
"Since optineurin interacts with CYLD, the role of optineurin in the regulation of NF-kappaB signalling is likely to be complex."
21408173
sparser
"In addition, OPTN interacts with CYLD, a deubiquitylase (DUB) for linear and K63 ubiquitin chains, which is able to negatively regulate NF-κB signalling via the deubiquitylation of a range of NF-κB signalling proteins including NEMO and RIPK1 ( xref ; xref )."
32376785
sparser
"Since optineurin interacts with CYLD, the role of optineurin in the regulation of NF-κB signalling is likely to be complex."
21408173
sparser
"Interaction of OPTN with CYLD is proposed to be involved in this regulation ( xref )."
29951055
biogrid
No evidence text available
21408173
biogrid
No evidence text available
25923723
biogrid
No evidence text available
21408173
reach
"Optineurin binds to polyubiquitinated RIP through its UBD and recruits CYLD; this may prevent association of NEMO with RIP (XREF_FIG)."
21408173
reach
"These results suggest that endogenous as well as overexpressed optineurin interacts with CYLD in mammalian cells."
21408173
biogrid
No evidence text available
25923723
sparser
"As expected, formation of the TBK1/CYLD complex was also reduced during the G2/M phase, while CYLD-Optn interaction remained unaffected as shown by co-immunoprecipitation and in situ PLA experiments performed in RO-treated cells (Fig xref , xref and xref , middle and lower panels, respectively)."
25923723
biogrid
No evidence text available
21408173
sparser
"Optineurin may be a ubiquitin-binding adaptor for CYLD in the TNFR pathway, since knockdown of optineurin impaired CYLD binding to RIP1 and NF-κB inhibition in TNF stimulated cells ( xref )."
22435550
reach
"As Optn and NEMO share structural homologies, interact both with the deubiquitinase CYLD and are both involved as regulators of the RIG/TBK/IRF signaling pathway [XREF_BIBR, XREF_BIBR, XREF_BIBR], a major issue will be to determine whether they interfere one with another through competitive interactions or coordinately act to regulate this pathway."
25923723
sparser
"C-terminal domain of Optineurin interacts with CYLD."
21408173
reach
"The deubiquitinase CYLD also interacts with optineurin and is a negative regulator of NF-kappaB signaling through binding of RIP, similar to optineurin."
29875767
sparser
"Here we have analysed the functional significance of interaction of optineurin with CYLD."
21408173
sparser
"Studies with the glaucoma-associated OPTN H486R mutant demonstrated loss of interaction of OPTN and CYLD, which resulted in increased NF- κ B signaling induced by inflammatory cytokines [ xref , xref ]."
33953963
sparser
"Our results thus show that the interaction of optineurin with CYLD is important for the regulation of TNFα-induced NF-κB activity."
21408173
sparser
"Subsequent work has shown that OPTN interacts with the deubiquitinase CYLD, a negative regulator of NF-κB that deubiquitinates RIP ( xref )."
29951055
sparser
"To examine the interaction of CYLD with optineurin in mammalian cells, co-immunoprecipitation assays were performed."
21408173
reach
"Interestingly, Optn interacts with the tumor suppressor gene CYLD, a deubiquitinase (DUB) that catalyzes the cleavage of linear and K63 linked polyubiquitin chains and with A20, a DUB for K63 linked polyubiquitinated signaling mediators such as TRAF6 and RIP1 [XREF_BIBR - XREF_BIBR]."
25923723
sparser
"Accordingly, an enzymatically inactive mutant of CYLD (H871N or H/N, [ xref ]) and a mutant of interaction of Optn with CYLD (H486R mutant, [ xref ]) failed to inhibit poly(I:C)-stimulated IFN-B gene expression compared to wt CYLD and Optn, respectively ( xref and xref Fig)."
25923723