IndraLab

Statements

USP10 translocates to the nucleus. 31 / 31
| 9 22
sparser
"Alternatively, USP10 could translocate into the nucleus to participate in DNA damage response."
20096447
sparser
"After DNA damage, USP10 is stabilised, and a fraction of USP10 translocates to the nucleus to activate p53."
23712866
sparser
"USP10 is upregulated and translocates to the nucleus following DNA damage and regulates p53-dependent DNA damage response."
20096447
sparser
"Interestingly USP10, a predominantly cytoplasmic DUB, is involved in homeostasis of cytoplasmic p53 in unstressed cells, but, following DNA damage, a fraction of USP10 can translocate into the nucleus where it contributes to p53 activation [ xref ]."
28900014
sparser
"Upon DNA damage, USP10 can translocate to the nucleus and also contribute to p53 activation xref xref ."
28233861
sparser
"Following DNA damage, USP10 also translocates to the nucleus and contributes to p53 activation."
20096447
sparser
"For example, USP10, a cytoplasmic DUB, translocates to the nucleus upon DNA damage where it contributes to the stabilization of p53 [ xref ]."
35008917
reach
"This process is very important during DNA-damage response, in which USP10 translocates to the nucleus and deubiquitinates p53, stabilizing it and thus regulating its response to DNA damage [113,114,115]."
32075244
sparser
"Following DNA damage, phosphorylation of USP10 by ATM leads to translocation of USP10 into the nucleus, where USP10 deubiquitinates and stabilizes nuclear p53 [ xref ]."
27844253
sparser
"Upon induction by DNA damage, a fraction of USP10 is phosphorylated by ATM and translocates to the nucleus where it deubiquitinates p53."
21624367
sparser
"Following DNA damage, a fraction of USP10 translocates to the nucleus and contributes to p53 activation."
34072267
reach
"Here, we demonstrated that a deubiquitinase USP10, which specifically stabilizes nuclear AID protein, can translocate into the nucleus after AKT-mediated phosphorylation at its T674 within the NLS domain."
34983926
reach
"Yuan et al. demonstrated that ATM could phosphorylate USP10 at Thr42 and Ser337 upon the DNA-damage response and USP10 was translocated into the nucleus, where the N-terminus of USP10 (amino acids 1–100) binds to p53 and inhibits its ubiquitination [27]."
35627217
sparser
"Following DNA damage, USP10 is stabilized and a fraction of USP10 translocates to the nucleus to activate p53."
20096447
sparser
"Yuan et al. demonstrated that ATM could phosphorylate USP10 at Thr42 and Ser337 upon the DNA-damage response and USP10 was translocated into the nucleus, where the N-terminus of USP10 (amino acids 1-100) binds to p53 and inhibits its ubiquitination [27] ."
35627217
reach
"Following DNA damage, USP10 also translocates to the nucleus and contributes to p53 activation."
20096447
reach
"USP10 is upregulated and translocates to the nucleus following DNA damage and regulates p53 dependent DNA damage response."
20096447
sparser
"After DNA damage, USP10 is stabilized, and a fraction of USP10 translocates to the nucleus to activate p53."
20096447
reach
"Under DNA damage, USP10 becomes stabilization and translocates to the nucleus to activate and stabilize nuclear p53."
31721429
sparser
"This process is very important during the DNA-damage response, when USP10 translocates to the nucleus and deubiquitinates p53, stabilizing it and thus regulating its response to DNA damage ( xref )."
30509983
reach
"In the case of DNA damage, USP10 is stabilized and translocates to the nucleus to activate and stabilize p53."
30319415
sparser
"This process is very important during DNA-damage response, in which USP10 translocates to the nucleus and deubiquitinates p53, stabilizing it and thus regulating its response to DNA damage [ xref , xref , xref ]."
32075244
sparser
"We also show that following genotoxic stress, a fraction of USP10 translocates to the nucleus, and this translocation is required for the stabilization and activation of p53."
20096447
sparser
"Under DNA damage, USP10 becomes stabilization and translocates to the nucleus to activate and stabilize nuclear p53."
31721429
reach
"USP10 translocates to the nucleus, aiding deubiquitination of p53 by USP7."
33095475
reach
"Upon DNA damage, USP10 can translocate to the nucleus and also contribute to p53 activation XREF_BIBR XREF_BIBR."
28233861
sparser
"Here, we demonstrated that a deubiquitinase USP10, which specifically stabilizes nuclear AID protein, can translocate into the nucleus after AKT-mediated phosphorylation at its T674 within the NLS domain."
34983926
sparser
"Following DNA damage, a fraction of USP10 translocates to the nucleus and contributes to p53 activation ( xref )."
20096447
sparser
"However, following DNA damage, part of USP10 translocate into nucleus to deubiquitylate p53 and thus boost p53 activation."
28031783
sparser
"Our results suggest that p53 is still ubiquitinated by residual Mdm2/Mdmx activity following DNA damage ( xref ), and the nuclear translocation of USP10 could further boost p53 activation."
20096447
sparser
"Following DNA damage or other genotoxic stress, a fraction of cytoplasmic USP10 is translocated into the nucleus, which is necessary for the activation and stabilization of p53."
32512887