IndraLab

Statements

STAT3 increases the amount of COPS5. 14 / 24
| 14
reach
"In summary, the present study demonstrates that the Src and Stat3 and C/EBP signaling pathways positively regulate the expression of the Jab1 oncogene."
21689417
reach
"Consistently, STAT3 silencing decreases the expression of Jab1/CSN5 and inhibits Jab1/CSN5 promoter activity in cancer cell lines ."
35315259
reach
"In turn, the oncogenic transcription factor STAT3 positively regulates JAB1 expression, indicative of a positive feedback loop."
29113268
reach
"Silencing of Stat3 in tumors reduced Jab1/Csn5 expression, thereby sensitizing nasopharyngeal carcinoma (NPC) cells to cisplatin- and radiation-induced apoptosis both in vitro and in vivo ( Pan et al.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30468907
reach
"We also identify a region whereby CCAAT and enhancer binding protein-beta (C/EBP-beta), signal transducer and activator of transcription-3 (Stat3), and GATA1 induce Jab1 transcription and identify a potential upstream oncogenic signaling molecule that may be key to the regulation of Jab1 expression in cancer."
21689417
reach
"STAT3 knockdown reduces JAB1 promoter activity, JAB1 mRNA, and JAB1 protein expression levels."
23911788
reach
"Our studies also revealed that Stat3 functions by binding to Jab1 and COPS5 promoter, promotes its activity and increases Jab1 and COPS5 transcription."
29535627
reach
"The mechanisms involved implies that CCL5 promotes the formation of the kappa-B p65/STAT3 complex, which activates COP9 signalosome 5 (CSN5) transcription, and then CSN5 further regulates the deubiquitination and stability of PD-L1, further inhibiting CD8+ T cell responses and thus leading to immune escape (67)( Figure 1 )."
36387070
reach
"Besides, upstream activators of Stat3, such as IL-6 and Src, also promote the activation of Jab1 and COPS5 transcription and translation through interacting with Stat3."
29535627
reach
"Stat3 Contributes to Cancer Progression by Regulating Jab1 and Csn5 Expression."
27524414
reach
"We further investigated whether an upstream activator of Stat3, the cytokine IL-6, could be driving increased Jab1 expression."
21689417
reach
"Interestingly, reactivation of Stat3 in normal mammary epithelial cells (MCF-10A, MCF-10F) is sufficient to reactivate Jab1 expression."
21689417
reach
"Treatment with the cytokine IL-6 resulted in increased Jab1 expression that was blocked by inhibition of Stat3."
21689417
reach
"Our previous studies demonstrated that Stat3 [XREF_BIBR] and non coding RNAs [XREF_BIBR] contribute to overexpression of Jab1 and COPS5 in cancer, and highly expressed Jab1 and COPS5 regulates DNA damage response, which confers chemotherapy and radiotherapy resistance to tumor cells [XREF_BIBR]."
29228627