IndraLab

Statements

ATXN3 increases the amount of DNAJB1. 5 / 5
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"When we conducted quantitative RT-PCR from fly heads that express polyQ78 in their eyes, we found that wild-type ataxin-3 increases the transcription levels of DnaJ-1."
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"When we conducted quantitative RT-PCR from fly heads that express polyQ78 in their eyes, we found that wild-type ataxin-3 increases the transcription levels of DnaJ-1 (XREF_FIG)."
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"These findings lead us to propose that ataxin-3, through its interaction with Rad23 and in a manner that depends on its deubiquitinase activity, leads to higher DnaJ-1 protein levels by increasing its transcription."
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"Altogether, our results propose a model whereby ataxin-3 increases DnaJ-1 levels in a manner that depends on the catalytic activity of this DUB and on its interaction with Rad23, and that DnaJ-1, acti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Altogether, our results propose a model whereby ataxin-3 increases DnaJ-1 levels in a manner that depends on the catalytic activity of this DUB and on its interaction with Rad23, and that DnaJ-1, acting downstream of the ataxin-3-Rad23 interaction, suppresses degeneration by decreasing polyQ aggregates."
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