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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CCDC6 inhibits USP7. 1 / 1

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"CCDC6 encodes for a pro apoptotic protein, often inactivated in thyroid and lung cancer upon fusion with various oncogenes [XREF_BIBR - XREF_BIBR]; CCDC6 is also impaired by somatic mutations, detected at low frequency in several tumors including bladder cancer (http://www.cbioportal.org/), as well as by its increased downregulation due to altered tuning of its modifying enzymes, the Fbxw7 E3 ubiquitin ligase and the USP7 deubiquitinase [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...