IndraLab

Statements

CCDC6 inhibits USP7. 1 / 1

| 1

reach

"CCDC6 encodes for a pro apoptotic protein, often inactivated in thyroid and lung cancer upon fusion with various oncogenes [XREF_BIBR - XREF_BIBR]; CCDC6 is also impaired by somatic mutations, detected at low frequency in several tumors including bladder cancer (http://www.cbioportal.org/), as well as by its increased downregulation due to altered tuning of its modifying enzymes, the Fbxw7 E3 ubiquitin ligase and the USP7 deubiquitinase [XREF_BIBR]."

30786932

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

CCDC6 inhibits USP7. 1 / 1

INDRA sources:

Databases

Reading