IndraLab

Statements

IL1R1 binds IL1RN. 66 / 71
1 2 | 7 56
sparser
"While IL-1R1 binds with IL-1Ra involving small conformational changes of the D3 domain [ xref ], significant changes were found when IL-1R1 binds with a peptide antagonist (AF10847)[ xref ]."
25706624
reach
"[31]The three commercially available IL-1 inhibitors are anakinra,canakinumab and rilonacept.Anakinra is a recombinant IL-1 receptor antagonist that binds toIL-1 receptor type 1 (IL-1R1), which is the target receptor for IL-1αand IL-1β."
34430870
sparser
"The rationale for testing the ability of the IL-1Ra to block the responses provides indirect evidence that precursor IL-1α, mature IL-1α, and mature IL-1β share the same receptor since IL-1Ra binds solely to IL-1R1."
24312098
sparser
"IL-1Ra binds to the IL-1R1 but fails to induce recruitment of the co-receptor IL-1R3 (aka IL-1RAcP), thus preventing signal transduction via the IL-1R. This is how it works as a competitive antagonist for both IL-1α and IL-1β."
35003136
sparser
"The low levels of IL-1β may depend on the increase of IL-1ra, that binds to IL1R1 and inhibits the activity of IL-1."
34360824
sparser
"It has been established that IL-1Ra binds to IL-1R1 and thus antagonizes biological effects of IL-1 [ xref ]."
22610882
sparser
"In contrast, anti-inflammatory IL-1RA binds to the IL-1R1 and blocks signaling events due to its lack of an essential IL-1R accessory protein (Tack et al., xref )."
23675368
reach
"Anakinra binds IL-1R1 blocking both IL-1α and IL-1β actions."
34599390
sparser
"In contrast, the enhanced interactions between squamous epithelial cells and macrophages in asymptomatic individuals were identified, including MIF-CD74, IL1RN-IL1R, AREG-ICAM1, and TNF/CCL4L2-VSIR (Supplementary Fig. S4d )."
34315869
sparser
"The IL-1Ra binds to IL-1R, blocking its interaction with IL-1 and inhibiting IL-1-mediated signal transduction."
10904249
sparser
"Moreover, IL-1RA can also bind IL-1R1 without inducing an activator signal, taking the place of IL-1β [ xref , xref ]."
32635472
sparser
"IL1RA binds to the interleukin 1 receptor type 1 (IL1R1) and blocks its activation."
29408900
sparser
"In addition, five amino acids are crucial for the interaction of IL-1RA with IL-1R [ xref ]."
32455586
sparser
"IL-1Ra binds IL-1R1 with an affinity higher than that of IL-1 but fails to recruit the IL-1RAcP."
24332029
sparser
"Anakinra as IL-1RA binds to the IL-1R and consequently prevents the binding of IL-1α as well as IL-1β to IL-1R1 and blocks their activity [ xref , xref ]."
34063964
sparser
"IL-1 signaling can be blocked by IL-1ra which binds to the IL-1R and blocks signal transduction [ xref ]."
30898979
sparser
"As an antagonist, binding of IL-1Ra to IL-1R1 prevents its coupling with IL-1RAcP and further signaling."
30987081
sparser
"IL-1Ra is able to bind to the IL-1R with similar affinity as IL-1α and IL-1β and inhibit IL-1 activity."
23936523
sparser
"IL-1Ra, which binds to IL-1Rs without transmitting an activation signal, represents a physiological inhibitor of pre-formed IL-1."
12147202
hprd
No evidence text available
11641511
sparser
"PE increases the expression of IL-1Ra in the CNS, which leads to the binding of IL-1Ra to IL-1R expressed on microglia, which inhibits the activity of IL-1α or IL-1β and thereby reduces microglial activation ( xref )."
34245811
sparser
"IL-1Ra competitively binds to IL-1R1 but does not have the capacity to activate IL-1 signaling."
26549942
sparser
"IL-1RA mainly binds IL-1R1, having little effect on IL-1R2, which is in agreement with their action as IL-1 inhibitor molecules [ xref ]."
35048046
sparser
"In contrast, most of the interactions of antagonist IL-1Ra with IL-1R1 (PDB entry 1IRA) are established with domains D1 and D2, exhibiting only a few contacts with D3 [ xref ]."
35163653
reach
"IL-1RN inhibits the activities of IL-1alpha and IL-1beta by binding to receptor IL1R1."
28068414
sparser
"A TMDD model was also applied to describe interactions of IL1R with HL2351 or anakinra."
32945613
sparser
"A similar effect was observed in IL1-R1 KO mice, suggesting that at high concentrations of IL-1Ra typically observed in obesity, IL-1Ra can contribute to the development of insulin resistance in a mechanism independent of IL-1Ra binding to IL-1R1."
25244011
sparser
"Thus, in our study the binding of IL-1ra by sIL-1RI may be allowing the IL-1β-mediated effects."
21595923
sparser
"Binding of IL-1RA to IL-1R1 leaves IL-1R1 unable to recruit IL-1R accessory protein for the transduction of IL-1-mediated actions [ xref ]."
26401121
sparser
"However, it was postulated that TLR4 activation in M1-like macrophages could suppress the production of an endogenous inhibitor of IL-1β, IL1Ra, which competitively binds to IL1R against IL-1β ( xref ), while in our study, we observed that SBP2 had the minimal effect of IL1Ra production in MMe."
31453320
sparser
"IL-1Ra can competitively bind with IL-1R1 against IL-1β or IL-1α."
33362770
sparser
"While IL-1 binding induces receptor signaling through additional binding to the IL-1 receptor accessory protein, IL-1Ra solely binds the IL-1R1 and, thus, acts as a competitive inhibitor."
29444430
sparser
"IL-1Ra binds to IL-1R1 without signaling and blocks binding of IL-1α/β xref ( xref )."
31611644
biogrid
No evidence text available
9062194
sparser
"IL-1Ra competitively binds to IL-1R1, thereby impeding the ability of IL-1β and IL-1α to bind to and signal through the receptor."
32038189
sparser
"IL-1Ra binds to IL-1R1 with comparable affinity to IL-1α and IL-1β but fails to induce the conformational change in the receptor that is required for the recruitment of the IL-1RAcP co-receptor and signal transduction [ xref , xref ]."
27001429
sparser
"It is also possible that IL-1Ra produced and released from islet resident macrophages and β-cells binds to IL-1R1 on α-cells resulting in positive IL-1Ra immunoreactivity in these cells."
28752047
sparser
"Polymorphisms in the IL-1β, IL-1RA, or IL-1R genes (as well as IL-6) have been reported in children with FS xref and could result in the following pro-convulsant circumstances: excessive 1L-1β release with saturation of IL-1Rs, defective IL-1RA production, inadequate IL-1RA release, defective IL-1RA binding to IL-1R. These genetic variations could provide yet another explanation for some of the extreme variability in the absolute cytokine levels in seen in our subjects."
28448686
sparser
"IL-1ra binds to IL-1R1 with an affinity that is 100–500 times higher than for IL-1R2 and competitively inhibits IL-1α/β binding to the receptor."
19307598
sparser
"IL-1Ra binds IL-1R, blocks IL-1R association with the accessory protein IL-1RAcP, and thereby interferes with IL-1 binding to the receptor."
18718859
sparser
"The low affinity for IL-1ra is consistent with the idea that both of these molecules serve to regulate the activity of IL-1?; if IL-1ra bound well to the type II IL-1R, they would negate each other's [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11790541
sparser
"We further characterized the sizes and binding of IL-1raBF and sIL-1RI to IL-1ra by polyacrylamide gel electrophoresis in the presence of sodium dodecylsulfate, ligand binding interference analyses, N-glycosidase treatment, concanavalin A affinity chromatography, and with the use of monoclonal antibodies (mAb) to human recombinant IL-1ra."
7589081
reach
"Anakinra as IL-1RA binds to the IL-1R and consequently prevents the binding of IL-1α as well as IL-1β to IL-1R1 and blocks their activity [110,111]."
34063964
hprd
No evidence text available
9062194
sparser
"The antagonist IL-1Ra also binds IL-1R1, competing with agonist IL-1 ligands and preventing the formation of the signalling complex ( xref )."
32754155
sparser
"IL-1Ra (MW ~ 17.6 kDa), a receptor antagonist of IL-1, can competitively bind with IL-1R1 thereby blocking cell activation by the cytokine [ xref ]."
31722745
reach
"On the mRNA level of MSC, we found IL1RN, which binds to IL1R on the cell surface with subsequent inhibition of the IL1beta signaling pathway, to be upregulated from a low basal level of expression upon stimulation with the PTC (318-fold) or IL1beta (107-fold) and to remain unchanged after stimulation with IL6, IL8, C3a and C5a in concentrations used in the " cocktail " (XREF_FIG)."
25562599
sparser
"IL-1RA binds to IL-1R1 with similar affinity to its biologically active counterparts, though binding fails to initiate downstream, intracellular signaling [ xref ]."
26930558
sparser
"In addition, the receptor antagonist IL-1Ra can bind to IL-1R1, and thereby prevents the formation of the IL-1R complex [ xref ]."
30042333
sparser
"IL-1R1 can also bind to IL-1Ra, which does not produce a signal due to its lack of an IL-1 receptor accessory protein interaction domain, thereby acting as a competitive binding factor to inhibit proinflammatory signaling [ xref ]."
34602858
sparser
"IL-1Ra binds to IL-1R on ECs and prevents proinflammatory events initiated by an IL-1 β  : IL-1R interaction, including enhanced influx of neutrophils, macrophages, and lymphocytes in inflamed lungs [ xref ]."
32257769
sparser
"In contrast to IL-1β, IL-1RA binds to IL-1R1 to inhibit IL-1 signaling xref , xref ."
30815893
sparser
"IL-1Ra binds to IL-1R with an avidity equal to that of IL-1 but fails to stimulate the cells, thus functioning as an inhibitor of IL-1 binding."
11357165
sparser
"IL-1R1 is the signalling receptor, which binds IL-1 and recruits the accessory chain IL-1R3 for initiating signalling, while the IL-1-like soluble antagonist IL-1Ra binds to IL-1R1, thereby preventing binding of agonist IL-1 molecules, and does not allow association of IL-1R3, thus inhibiting signal transduction."
29422069
sparser
"There are a limited number of anti-inflammatory therapies that target IL-1 signaling; this includes anakinra (commercially known as Kineret), a recombinant form of IL-1Ra that binds competitively to IL-1R and non-selectively blocks downstream signaling [ xref ]."
33246504
sparser
"Moreover, the soluble form of IL-1R1 and IL-1RA have the highest capacity to prevent IL-1α while IL-1R2 and IL-1R1 and IL-1RA have a similar capacity to prevent IL-1β signaling."
31830463
sparser
"The availability of anakinra, a nonglycosylated recombinant human IL-1Ra that binds to IL-1R1 competitively inhibiting IL-1 signaling, provides an interesting and safe tool for therapeutic intervention."
26273700
sparser
"IL-1Ra binds IL-1R, making the receptor unavailable for binding IL-1α, without activating the IL-1α pathway, whereas the anti-IL-1α antibody sequesters unbound IL-1α and prevents it from binding to the receptor."
29449647
sparser
"However, against this hypothesis is our observation that IL-1Ra was able to antagonize LPS-driven inflammation, which itself requires the binding of IL-1Ra to type I IL-1R."
28957335
reach
"Both IL-1RA and anakinra bind to the IL-1R in the same manner and interfere with the binding of IL-1α and IL-1β, thereby blocking their activity.Anakinra is administered subcutaneously (SC) in a daily injection containing 100 mg/0.67 mL solution."
35409316
sparser
"Anakinra as IL-1RA binds to the IL-1R and consequently prevents the binding of IL-1α as well as IL-1β to IL-1R1 and blocks their activity [110, 111] ."
34063964
sparser
"As a control, the same attempt was made on the crystal structure of IL-1R bound to IL-1ra and, as expected, no interaction could be calculated (data not shown)."
11418113
sparser
"IL-1R1 can also bind the antagonist IL-1Ra, which blocks the formation of the signalling complex thereby inhibiting IL-1-induced receptor-mediated inflammatory activation."
30541566
reach
"Notably, the opposite (protective) allele IL1RN * 2 has been previously associated with higher IL-1Ra and lower IL-1beta release XREF_BIBR."
26972847
sparser
"IL-1Ra binds IL-1R1, competitively inhibiting the binding and activities of IL-1β and IL-1α."
26692253
sparser
"When IL-1Ra binds to IL-1R1 ( xref ), the conformational change (shown in xref ) does not result IL-1R3 binding."
32324502