IndraLab

Statements

IL1R1 binds IL1RN. 145 / 150
1 2 2 | 13 127
biogrid
No evidence text available
33961781
sparser
"In contrast, most of the interactions of antagonist IL-1Ra with IL-1R1 (PDB entry 1IRA) are established with domains D1 and D2, exhibiting only a few contacts with D3 [ xref ]."
35163653
sparser
"IL-1ra binds to IL-1R as a competitive inhibitor of IL-1 binding, without inducing cellular responses after ligation."
11060753
sparser
"This way, antagonist IL-1Ra binds to IL-1R, inhibiting cytokines IL-1α and IL-1β."
35303546
sparser
"The IL-1Ra binds to IL-1R, blocking its interaction with IL-1 and inhibiting IL-1-mediated signal transduction."
10904249
sparser
"The IL-1 signaling pathway is tightly regulated at multiple levels, including extracellularly by the decoy receptor IL-1R2, which lacks a cytoplasmic domain and therefore binds IL-1 (with a greater affinity for IL-1β than IL-1α) without activating a cellular response [ xref , xref , xref ], and the competitive antagonist IL-1Ra, which binds IL-1R1 with high affinity, blocking the binding of IL-1 [ xref ]."
36769133
sparser
"The rationale for testing the ability of the IL-1Ra to block the responses provides indirect evidence that precursor IL-1α, mature IL-1α, and mature IL-1β share the same receptor since IL-1Ra binds solely to IL-1R1."
24312098
sparser
"IL-1Ra binds with a high affinity to IL-1R1 [12] , but, despite similar binding affinity, the two IL-1 agonists and IL-1Ra interact differently with IL-1R1."
26185894
sparser
"IL-1R1 can also bind to IL-1Ra, which does not produce a signal due to its lack of an IL-1 receptor accessory protein interaction domain, thereby acting as a competitive binding factor to inhibit proinflammatory signaling [ xref ]."
34602858
sparser
"When IL-1Ra binds to the corresponding IL-1R, the interaction of IL-1 and IL-1R is blocked."
37273484
sparser
"IL-1ra binds to IL-1R1 with an affinity that is 100–500 times higher than for IL-1R2 and competitively inhibits IL-1α/β binding to the receptor."
19307598
sparser
"Moreover, the soluble form of IL-1R1 and IL-1RA have the highest capacity to prevent IL-1α while IL-1R2 and IL-1R1 and IL-1RA have a similar capacity to prevent IL-1β signaling."
31830463
sparser
"In contrast to IL-1β, IL-1RA binds to IL-1R1 to inhibit IL-1 signaling xref , xref ."
30815893
sparser
"IL-1Ra binds the receptor IL-1R1 with affinity higher than that of IL-1α or IL-1β, but it does not trigger the association of IL-1 receptor accessory protein, thus there is no activation of the IL-1 signaling [ xref ]."
36680273
sparser
"IL-1 signaling can be blocked by IL-1ra which binds to the IL-1R and blocks signal transduction [ xref ]."
30898979
sparser
"IL-1RA binds to IL-1R1 with equal or greater affinity than IL-1α and IL-1β but does not activate downstream signaling ( xref , xref , xref )."
36938490
sparser
"IL-1Ra can competitively bind with IL-1R1 against IL-1β or IL-1α."
33362770
sparser
"For example, in two separate datasets pertaining to breast cancer, IL1RN–IL1R1 was responsible for 3,779 and 1,445 new cases, respectively."
38054018
sparser
"Binding of IL-1RA to IL-1R1 leaves IL-1R1 unable to recruit IL-1R accessory protein for the transduction of IL-1-mediated actions [ xref ]."
26401121
sparser
"When IL-1Ra binds to IL-1R1 ( xref ), the conformational change (shown in xref ) does not result IL-1R3 binding."
32324502
sparser
"IL-1RA can also bind IL-1R1 and prevent the recruitment of the co-receptor, acting as an antagonist."
29366546
sparser
"IL-1Ra binds non-productively IL-1R preventing cell signaling effects of IL‐1α and IL-1β and antagonizes the pro-inflammatory response [52] ."
34147295
sparser
"Conversely, in the interaction model of IL-1R3 with the IL-1Ra–IL-1R1 complex, only domain 2 of IL-1R3 establishes contact, resulting in an unstable interaction ( xref )."
38974214
sparser
"Furthermore, the formation of the IL-1Ra-IL-1R1 complex induces a distinct conformational change compared to that which occurs upon IL-1α/β binding."
38974214
sparser
"IL-1Ra binds IL-1R1, competitively inhibiting the binding and activities of IL-1β and IL-1α."
26692253
sparser
"We further characterized the sizes and binding of IL-1raBF and sIL-1RI to IL-1ra by polyacrylamide gel electrophoresis in the presence of sodium dodecylsulfate, ligand binding interference analyses, N-glycosidase treatment, concanavalin A affinity chromatography, and with the use of monoclonal antibodies (mAb) to human recombinant IL-1ra."
7589081
sparser
"The antagonist IL-1Ra also binds IL-1R1, competing with agonist IL-1 ligands and preventing the formation of the signalling complex ( xref )."
32754155
biogrid
No evidence text available
9062194
sparser
"The low affinity for IL-1ra is consistent with the idea that both of these molecules serve to regulate the activity of IL-1?; if IL-1ra bound well to the type II IL-1R, they would negate each other's [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11790541
sparser
"Both cytokines signal through IL-1R1 and its accessory protein IL-1R3, which can be efficiently inhibited by IL-1Ra that competitively binds IL-1R1 but does not recruit the accessory protein [ xref ]."
39234208
sparser
"39 Mutating the Lys131 to glutamine destabilized the interaction of IL-1R1 and IL-1Ra with a ΔΔG of 0.6308 kcal/mol, as predicted by Fold-X ( Figure S3 B)."
37315560
sparser
"Both co-immunoprecipitation ( Figure 3 A) and pull-down assay ( Figure S3 C) demonstrated that the K131E substitution impaired the interaction between IL-1R1 and IL-1Ra, but not between IL-1R1 and IL-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37315560
sparser
"The KD values of wild-type (WT) and K131E mutant IL-1R1 binding to IL-1Ra were 3.690 × 10 −11 and 1.415 × 10 −9 M, respectively, confirming the reduced binding affinity of the mutant IL-1R1 to its ant[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37315560
hprd
No evidence text available
9062194
reach
"Anakinra as IL-1RA binds to the IL-1R and consequently prevents the binding of IL-1α as well as IL-1β to IL-1R1 and blocks their activity [110,111]."
34063964
sparser
"These biologic agents target the blockade of pro-inflammatory cytokines such as IL-1 (anakinra-IL-1R antagonist), (canakinumab, rilonacept- anti-IL-1β monoclonal antibody), IL-6 (tocilizumab) and TNF (etanercept, infliximab)."
37033555
hprd
No evidence text available
11641511
sparser
"According to the Fold-X prediction, Lys131 substitutions to negatively charged amino acids Glu (E) or Asp (D) requires excessive energy compared with positively charged amino acids His (H) or Arg (R),[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37315560
sparser
"In summary, IL-1 molecules (IL-1α and IL-1β) are prototypic proinflammatory cytokines that play a role in inflammatory processes by combining to the IL-1 receptor (IL-1R), whereas their antagonist, IL-1Ra, binds to IL-1R1, inhibiting the integration of IL-1R1 with IL-1α and IL-1β ( xref )."
39935474
sparser
"The disrupted interaction between IL-1R1 K131E or K131D and IL-1Ra was demonstrated by co-immunoprecipitation ( Figure 4 C)."
37315560
reach
"Anakinra, a recombinant form of IL-1Ra, directly binds to and blocks IL1R1."
38127662
sparser
"The patient is able to rope skipping after treatment with canakinumab for 3 months, related to Figure 6 The effect of this IL-1R1 mutation demonstrates the importance of the interaction between IL-1R[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37315560
sparser
"The substitution of a basic, polar amino acid at residue 131 with an acidic amino acid disrupted the interaction of IL-1R1 with IL-1Ra."
37315560
sparser
"Our results demonstrated that K131E substitution on IL-1R1 leads to the constitutive inflammation by impairing the interaction between IL-1R1 and IL-1Ra."
37315560
sparser
"52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 However, all the associated SNPs are either located in the noncoding region (intergenic/intronic/UTR) of IL1RN gene or are synonymous variants, which do not affec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37315560
sparser
"IL-1Ra binds to IL-1R1 with comparable affinity to IL-1α and IL-1β but fails to induce the conformational change in the receptor that is required for the recruitment of the IL-1RAcP co-receptor and signal transduction [ xref , xref ]."
27001429
sparser
"51 Our data suggested that the charge stability of lysine 131 in IL-1R1 is critical for the interaction of IL-1R1 with IL-1Ra."
37315560
sparser
"IL-1Ra (MW ~ 17.6 kDa), a receptor antagonist of IL-1, can competitively bind with IL-1R1 thereby blocking cell activation by the cytokine [ xref ]."
31722745
sparser
"IL-1R1 is the signalling receptor, which binds IL-1 and recruits the accessory chain IL-1R3 for initiating signalling, while the IL-1-like soluble antagonist IL-1Ra binds to IL-1R1, thereby preventing binding of agonist IL-1 molecules, and does not allow association of IL-1R3, thus inhibiting signal transduction."
29422069
reach
"The receptor IL1R1 binds IL-1α, IL-1β, and IL1RN."
37460545
sparser
"IL-1Ra binds to IL-1R1 but does not recruit the accessory chain IL-1R3 and does not initiate signal transduction [28] ."
24246227
sparser
"The crystal structure of the IL-1R1–IL-1Ra complex showed that IL-1Ra binds at the large groove area between D1 and D2, but it fails to interact with the small area on D3 [31] ."
24246227
sparser
"IL-1Ra binds IL-1R1 with an affinity higher than that of IL-1 but fails to recruit the IL-1RAcP."
24332029
reach
"Notably, the opposite (protective) allele IL1RN * 2 has been previously associated with higher IL-1Ra and lower IL-1beta release XREF_BIBR."
26972847
sparser
"In the case of the IL-1Ra–IL-1R1 complex, the accessory chain IL-1R3 fails to be recruited, and therefore signalling does not occur [28] ."
24246227
sparser
"As a control, the same attempt was made on the crystal structure of IL-1R bound to IL-1ra and, as expected, no interaction could be calculated (data not shown)."
11418113
sparser
"The same studies shows that in the model of IL-1R3 interacting with the IL-1Ra–IL-1R1 complex, only domain 2 of IL-1R3 can take contact, resulting in unstable interaction."
24246227
sparser
"In vivo, IL-1ra binds to IL-1R1 without protein dimerization, thus inhibiting downstream activities [ xref ]."
37610701
reach
"For instance, anakinra binds to IL-1R1 and inhibits its interaction with IL-1β."
37079558
sparser
"For example, ANXA1-FPR1 system is potent effective mediators in anti-inflammatory processes xref , and their interaction was lost between CECs and ImCs in KC samples; IL1RN-IL1R1 are natural anti-inflammatory cytokines xref , and their interaction were eliminated between CECs and CSCs in KC samples."
35821117
sparser
"Modeling IL-1RA interactions with IL-1R1"
38988763
sparser
"IL-1Ra binds to the same IL-1R1 as IL-1α and IL-1β, thus limiting the pro-inflammatory signaling that these cytokines induce ( xref ; xref )."
35832789
sparser
"The results also showed that ligand–receptor binding associated with protease inhibition (e.g., TIMP1-EGFR) and anti-inflammatory processes (e.g., ANXA1-FPR1 and IL1RN-IL1R1) was notably absent in various cells in keratoconus, providing deeper insights for diagnosis and treatment."
40426861
sparser
"IL-1RA binds to IL-1R1 with similar affinity to its biologically active counterparts, though binding fails to initiate downstream, intracellular signaling [ xref ]."
26930558
sparser
"IL-1Ra binds the receptor IL-1R1 with a higher affinity than IL-1α or IL-1β, although without activation of the IL-1 signaling [ xref ]."
37446274
sparser
"We spotted that ANXA1-FPR1, and IL1RN-IL1R1, whose anti-inflammatory roles have been reported, were erased in KC samples, implying their impact on the increased inflammation in keratoconus."
35821117
sparser
"IL-1R1 can also bind the antagonist IL-1Ra, which blocks the formation of the signalling complex thereby inhibiting IL-1-induced receptor-mediated inflammatory activation."
30541566
sparser
"In this disease, the mutation characteristically disrupts the interaction of IL-1R1 with IL-1Ra."
38646532
sparser
"While IL-1R1 binds with IL-1Ra involving small conformational changes of the D3 domain [ xref ], significant changes were found when IL-1R1 binds with a peptide antagonist (AF10847)[ xref ]."
25706624
sparser
"IL-1Ra binds to the IL-1R1 but fails to induce recruitment of the co-receptor IL-1R3 (aka IL-1RAcP), thus preventing signal transduction via the IL-1R. This is how it works as a competitive antagonist for both IL-1α and IL-1β."
35003136
sparser
"Thus, in our study the binding of IL-1ra by sIL-1RI may be allowing the IL-1β-mediated effects."
21595923
sparser
"The stable complex of IL-1Ra-ABD with IL-1R established the absence of steric hindrance due to the addition of ABD to IL-1Ra."
39035819
reach
"Anakinra exerts its anti-inflammatory effects by binding to the IL-1R, which inhibits the interaction of both IL-1α and IL-1β with the receptor."
36839968
sparser
"Despite of the isoform, IL-1RA binds to IL-1R1 with high affinity but does not initiate the signaling cascade, thus acting as a competitive inhibitor of IL-1α and IL-1β xref , xref ."
41535359
signor
"Homozygous truncating mutations result in lack of secreted interleukin-1–receptor antagonist protein, which inhibits the proinflammatory cytokines interleukin-1α and interleukin-1β"
2876877
sparser
"Studies have reported that the loss of IL1RN-IL1R1 ligand–receptor binding may significantly impact the progression of keratoconus [ xref ]."
40426861
sparser
"IL-1Ra binds to IL-1R1 with a high affinity and inhibits IL-1α or IL-1β function ( xref )."
35137920
sparser
"Since IL-1Ra binds to IL-1R1 (common receptor for both IL-1β and IL-1α) ( xref ), it may inhibit the function of IL-1β and IL-1α cytokines."
35137920
sparser
"IL-1RA mainly binds IL-1R1, having little effect on IL-1R2, which is in agreement with their action as IL-1 inhibitor molecules [ xref ]."
35048046
reach
"Patients suffering from AID caused by increased IL-1β signaling showed good response with anakinra, rilonacept (recombinant IL-1 receptor IL-1R that binds to IL-1α, IL-1β, and IL-1RA), and canakinumab (human monoclonal antibody that binds to IL-1β) (Georgin-Lavialle et al., 2019; Blackstone et al., 2023)."
39624485
sparser
"IL-1Ra competitively binds to IL-1R1, thereby blocking binding of IL1α and IL1β [ 82 ]."
30181021
sparser
"Additionally, the immune cells in the corneal stroma of KTCN exhibited a reduced expression of the anti-inflammatory gene IL1RN , along with the loss of ligand–receptor binding associated with IL1RN-IL1R1."
40426861
sparser
"Conversely, LTP amplitude decreased with IL-1Ra treatment, possibly by blocking IL-1R1, although the interaction between IL-1Ra and IL-1R1 was not determined [ xref ]."
40966229
sparser
"IL-1Ra binds to IL-1R1 without signaling and blocks binding of IL-1α/β xref ( xref )."
31611644
sparser
"Anakinra as IL-1RA binds to the IL-1R and consequently prevents the binding of IL-1α as well as IL-1β to IL-1R1 and blocks their activity [ xref , xref ]."
34063964
sparser
"Since IL-1RA interacts with IL-1R1, IL-1RAP, and the IL- 1R1+IL-1RAP complex (Fig. 1), three-dimensional structures of the corresponding proteins were required for modeling and analysis."
38988763
reach
"IL-1RN inhibits the activities of IL-1alpha and IL-1beta by binding to receptor IL1R1."
28068414
sparser
"The availability of anakinra, a nonglycosylated recombinant human IL-1Ra that binds to IL-1R1 competitively inhibiting IL-1 signaling, provides an interesting and safe tool for therapeutic intervention."
26273700
sparser
"IL-1Ra bound IL-1R1 cannot productively signal through IL-1R3."
35832789
sparser
"Modeling interaction of standard IL-1RA with IL-1R1."
38988763
sparser
"According to the contact list of template residues, serine at position 130 of the IL-1RA molecule binds to leucine at position 237 of IL-1R1 (see Table 4)."
38988763
sparser
"Modeling interaction of IL-1RA with the rs315952 polymorphism with IL-1R1."
38988763
sparser
"Thus, based on the interactions of IL-1RA with the rs315952 polymorphism with IL-1R1, we cannot draw a definitive conclusion regarding the polymorphism’s impact on its involvement in initiating the IL-1 signaling pathway."
38988763
sparser
"In addition, five amino acids are crucial for the interaction of IL-1RA with IL-1R [ xref ]."
32455586
sparser
"IL-1Ra binds IL-1R, making the receptor unavailable for binding IL-1α, without activating the IL-1α pathway, whereas the anti-IL-1α antibody sequesters unbound IL-1α and prevents it from binding to the receptor."
29449647
sparser
"Meanwhile, IL-1Ra competitively binds to IL-1R1, effectively blocking the interaction and subsequent signaling of IL-1α and IL-1β [ xref , xref ]."
39408843
sparser
"However, it was postulated that TLR4 activation in M1-like macrophages could suppress the production of an endogenous inhibitor of IL-1β, IL1Ra, which competitively binds to IL1R against IL-1β ( xref ), while in our study, we observed that SBP2 had the minimal effect of IL1Ra production in MMe."
31453320
sparser
"When the antagonistic IL-1RA binds to IL-1R1, it competes with IL-1α and IL-1β and induces conformational changes that prevent IL-1RAP recruitment [ xref ]."
41413691
sparser
"However, against this hypothesis is our observation that IL-1Ra was able to antagonize LPS-driven inflammation, which itself requires the binding of IL-1Ra to type I IL-1R."
28957335
sparser
"This is exemplified for IL-1RA [ 33 , 34 ], which binds to IL-1R1 with the same affinity than IL-1 [ 35 ]."
32898612
sparser
"IL-1Ra binds to IL-1R1, and this cytokine work as the inhibitor of IL-1α and IL-1β ( xref , xref ) ( xref )."
37881433
sparser
"IL1RA binds to the interleukin 1 receptor type 1 (IL1R1) and blocks its activation."
29408900
sparser
"IL-1Ra binds IL-1R1 without recruitment of IL-1RAcP, resulting in the inhibition of IL-1α and IL-1β binding in a competitive manner."
29366788
sparser
"A similar effect was observed in IL1-R1 KO mice, suggesting that at high concentrations of IL-1Ra typically observed in obesity, IL-1Ra can contribute to the development of insulin resistance in a mechanism independent of IL-1Ra binding to IL-1R1."
25244011
reach
"On the mRNA level of MSC, we found IL1RN, which binds to IL1R on the cell surface with subsequent inhibition of the IL1beta signaling pathway, to be upregulated from a low basal level of expression upon stimulation with the PTC (318-fold) or IL1beta (107-fold) and to remain unchanged after stimulation with IL6, IL8, C3a and C5a in concentrations used in the " cocktail " (XREF_FIG)."
25562599
sparser
"IL-1Ra binds with IL-1R [ xref , xref ], and IL-1R signaling is critical for neutrophil function [ xref , xref , xref ]."
39536069
sparser
"Moreover, IL-1RA can also bind IL-1R1 without inducing an activator signal, taking the place of IL-1β [ xref , xref ]."
32635472
sparser
"As an antagonist, binding of IL-1Ra to IL-1R1 prevents its coupling with IL-1RAcP and further signaling."
30987081
sparser
"This may be because IL-1RA directly binds IL-1R, but not IL-1β, to block the biological effects of IL-1β."
28283331
sparser
"IL-1Ra competitively binds to IL-1R1 but does not have the capacity to activate IL-1 signaling."
26549942
sparser
"IL-1Ra binds to IL-1R on ECs and prevents proinflammatory events initiated by an IL-1 β  : IL-1R interaction, including enhanced influx of neutrophils, macrophages, and lymphocytes in inflamed lungs [ xref ]."
32257769
sparser
"In addition, the receptor antagonist IL-1Ra can bind to IL-1R1, and thereby prevents the formation of the IL-1R complex [ xref ]."
30042333
sparser
"IL-1RA binds to IL-1R with a high affinity and competitively interferes with the binding of IL-1 to IL-1R as an inhibitory protein for IL-1 activity."
36589291
reach
"Anakinra binds IL-1R1 blocking both IL-1α and IL-1β actions."
34599390
sparser
"The results showed that the competitive binding of IL-1Ra to the IL-1R reduced the recruitment of macrophages and the phagocytosis of copper ions triggers intracellular ROS production, leading to macr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36690300
sparser
"IL-1Ra is able to bind to the IL-1R with similar affinity as IL-1α and IL-1β and inhibit IL-1 activity."
23936523
sparser
"Currently, several commercially available drugs target the IL-1 pathway, such as anakinra (IL-1RA that binds to IL-1R1), canakinumab (a human monoclonal IgG1 antibody for blocking IL-1β), rilonacept (a soluble decoy fusion protein that competitively binds to IL-1R) and gevokizumab (a humanized monoclonal anti-IL-1β) ( xref )."
37304814
sparser
"IL-1Ra binds to IL-1R1, but is unable to activate the IL-1 intracellular signaling pathways [ xref ]."
36145533
sparser
"While IL-1 binding induces receptor signaling through additional binding to the IL-1 receptor accessory protein, IL-1Ra solely binds the IL-1R1 and, thus, acts as a competitive inhibitor."
29444430
reach
"Both IL-1RA and anakinra bind to the IL-1R in the same manner and interfere with the binding of IL-1α and IL-1β, thereby blocking their activity.Anakinra is administered subcutaneously (SC) in a daily injection containing 100 mg/0.67 mL solution."
35409316
reach
"Thus, the availability of IL1R2 transcripts for analyses in this study may have been diluted by mRNA transcripts produced by the other cell types.Functional IL-1RN binds to IL-1R and inhibits interact[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25108787
sparser
"IL-1Ra binds to IL-1R1 but unlike IL-1α or IL-1β, the binding of IL-1Ra to IL-1R1 does not result in signaling."
37866732
sparser
"Functional IL-1RN binds to IL-1R and inhibits interaction of IL-1 α and IL-1 β signaling ligands with the receptor ( Seckinger et al., 1987 )."
25108787
sparser
"Firstly, we examined the expression levels of IL1A, its receptor IL1R1, and the antagonist IL1R1-IL1RN in four cell types ( xref a)."
37371115
sparser
"Recombinant human IL-1Ra (rhIL-1Ra) as a genetically engineered drug has been found to have the same biological function as natural IL-1Ra both of which can bind specifically to IL-1R to inhibit various inflammatory diseases, like encephalomyelitis [ xref ], intestinal mucositis [ xref ], arthritis [ xref ], and even cancer [ xref , xref ]."
38835041
reach
"However, anakinra can inhibit the activity of IL-1α and IL-1β by binding to IL-1R [41], thereby reducing the inflammatory response and tissue damage caused by IL-1 (Fig. 1, created with biorender.com)."
36462104
sparser
"With high affinity, IL-1Ra binds to IL-1R1 and, thus, inhibits IL-1α or IL-1β activity [ xref ]."
38139443
sparser
"IL-1ra binds to the IL-1R but exerts no biological activity and therefore functions as a competitive inhibitor of IL-1 signaling."
24680647
sparser
"IL-1Ra binds to IL-1R1 and competitively blocks IL-α and IL-1β [ xref ]."
39682161
sparser
"IL-1 signaling can be inhibited by the endogenous ligand IL-1Ra, which can bind to IL-1R1 without inducing the dimerization with IL-1RAcP resulting in prevention of IL-1 signaling [60] ."
32088265
sparser
"It has been established that IL-1Ra binds to IL-1R1 and thus antagonizes biological effects of IL-1 [ xref ]."
22610882
sparser
"IL-1Ra binds IL-1R, blocks IL-1R association with the accessory protein IL-1RAcP, and thereby interferes with IL-1 binding to the receptor."
18718859
sparser
"IL-1Ra competitively binds to IL-1R1, thereby impeding the ability of IL-1β and IL-1α to bind to and signal through the receptor."
32038189
sparser
"PE increases the expression of IL-1Ra in the CNS, which leads to the binding of IL-1Ra to IL-1R expressed on microglia, which inhibits the activity of IL-1α or IL-1β and thereby reduces microglial activation ( xref )."
34245811
sparser
"IL-1Ra binds with IL-1R [ xref , xref ], and IL-1R signaling is critical for neutrophil function [ xref , xref , xref ]."
39463935
sparser
"IL-1Ra, which binds to IL-1Rs without transmitting an activation signal, represents a physiological inhibitor of pre-formed IL-1."
12147202
sparser
"It is possible that IL-1RA may bind to IL-1R, modulating NFκB pathway members xref , altering the phosphorylation status of AR, and ultimately leading to AR stabilization."
39455902
sparser
"Firstly, IL-1RA competitively binds to the IL-1R1 with a high affinity to prevent its binding with agonistic ligands."
35523814
sparser
"In contrast, anti-inflammatory IL-1RA binds to the IL-1R1 and blocks signaling events due to its lack of an essential IL-1R accessory protein (Tack et al., xref )."
23675368
sparser
"IL-1Ra binds to IL-1R with an avidity equal to that of IL-1 but fails to stimulate the cells, thus functioning as an inhibitor of IL-1 binding."
11357165
sparser
"There are a limited number of anti-inflammatory therapies that target IL-1 signaling; this includes anakinra (commercially known as Kineret), a recombinant form of IL-1Ra that binds competitively to IL-1R and non-selectively blocks downstream signaling [ xref ]."
33246504
sparser
"IL-1RA is structurally related to IL-1α and IL-1β (described above) and binds the shared IL-1R1 with similar high affinity as IL-1β."
38059210
sparser
"However, subtle structural differences between IL-1β and IL-1RA result in the inability of the co-receptor IL-1RacP to be recruited to the complex following binding of IL-1RA to IL-1R1 [ xref ]."
38059210
sparser
"Polymorphisms in the IL-1β, IL-1RA, or IL-1R genes (as well as IL-6) have been reported in children with FS xref and could result in the following pro-convulsant circumstances: excessive 1L-1β release with saturation of IL-1Rs, defective IL-1RA production, inadequate IL-1RA release, defective IL-1RA binding to IL-1R. These genetic variations could provide yet another explanation for some of the extreme variability in the absolute cytokine levels in seen in our subjects."
28448686
sparser
"IL-1Ra competitively binds to the IL-1R1, receptor of IL-1beta, and blocks its activation ( Palomo et al., 2015 ) However, elevated levels of IL-1Ra were shown to be associated with increased risk of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27492721