IndraLab

Statements

USP7 activates TRIP12. 5 / 6
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"Thus, USP7 increases the stability of TRIP12, whereas the TRIP12 does the opposite for USP7."
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"The regulation of TRIP12 by USP7 was confirmed in HPV(+) cells, where forced expression of USP7 led to significant upregulation of TRIP12 (Fig. 2C), despite the presence of p16, suggesting that p16 regulates TRIP12 through USP7.Although inhibition of USP7 reduced TRIP12 protein expression, it did not reduce TRIP12 mRNA (Supplementary Fig. S2B), providing evidence that TRIP12 regulation occurs post-translationally."
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"Cycloheximide chase assays in TP53 mutant HN5 and TP53 wild-type HN30 cells both showed a reduced half-life of TRIP12 after USP7 knockdown (Fig. 2D and E), which, although not a comprehensive evaluation of p53 in this setting, supports a potentially p53-independent mechanism of TRIP12 stabilization by USP7."
34965932
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"Similarly TRIP12 was consistently decreased by USP7 silencing, although in most cases there was little to no rescue of the levels with MG132 treatment."
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"Whereas, USP7 accelerates p14ARF degradation by stabilizing its E3 ligase TRIP 12 and promotes the progression of hepatocellular carcinoma [48] ."
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