IndraLab

Statements

USP7 activates TRIP12. 4 / 5
| 4
reach
"Cycloheximide chase assays in TP53 mutant HN5 and TP53 wild-type HN30 cells both showed a reduced half-life of TRIP12 after USP7 knockdown (Fig. 2D & E), which, although not a comprehensive evaluation of p53 in this setting, supports a potentially p53-independent mechanism of TRIP12 stabilization by USP7."
34965932
reach
"Thus, USP7 increases the stability of TRIP12, whereas the TRIP12 does the opposite for USP7."
29858610
reach
"The regulation of TRIP12 by USP7 was confirmed in HPV(+) cells, where forced expression of USP7 led to significant upregulation of TRIP12 (Fig. 2C), despite the presence of p16, suggesting that p16 regulates TRIP12 through USP7."
34965932
reach
"Similarly TRIP12 was consistently decreased by USP7 silencing, although in most cases there was little to no rescue of the levels with MG132 treatment."
30367141