IndraLab
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"Cycloheximide chase assays in TP53 mutant HN5 and TP53 wild-type HN30 cells both showed a reduced half-life of TRIP12 after USP7 knockdown (Fig. 2D & E), which, although not a comprehensive evaluation of p53 in this setting, supports a potentially p53-independent mechanism of TRIP12 stabilization by USP7."
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"Thus, USP7 increases the stability of TRIP12, whereas the TRIP12 does the opposite for USP7."
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"The regulation of TRIP12 by USP7 was confirmed in HPV(+) cells, where forced expression of USP7 led to significant upregulation of TRIP12 (Fig. 2C), despite the presence of p16, suggesting that p16 regulates TRIP12 through USP7."
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"Similarly TRIP12 was consistently decreased by USP7 silencing, although in most cases there was little to no rescue of the levels with MG132 treatment."