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ERK phosphorylates STAT3 on serine. 26 / 26
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"Furthermore, our study reveals that PDGF-BB- and bFGF induced proliferation does not affect the osteogenic differentiation potential of hBMMSCs.All of the three GFs activated the hBMMSC ERK1/2 pathway[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results strongly suggest that STAT3 serine phosphorylation upon BMP2 and BMP4 stimulation is distinctively mediated by mTOR and ERK1/2, respectively, in human MSCs.Next, we sought to corroborate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, we show that STAT3 serine phosphorylation is induced by ERK and JNK as a downstream effect of FGFR signaling and it does not require over-expression of FGFRs."
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"Notably, inhibition of the ERK1/2 pathway greatly decreased STAT3 serine phosphorylation in response to PDGF-BB, indicating that ERK1/2 mediate PDGF-BB-induced STAT3 serine phosphorylation."
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"STAT1 serine phosphorylation was perturbed by inhibition of ERK and p38 pathways, whereas only inhibition of ERK activation blocked STAT3 serine phosphorylation in response to EPO."
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"Furthermore, stimulation with SCF and PMA, previously shown to induce phosphorylation of ERK and subsequent serine phosphorylation of STAT3, also resulted in the activation of MSK1 (data not shown)."
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rlimsp
"We also found that WKYMVm stimulated extracellular signal regulated kinase (ERK), and that ERK activity is required for STAT3 serine phosphorylation."
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"To determine whether ERK1/2 also mediate PDGF-BB-induced STAT3 serine phosphorylation, PD98059, a specific inhibitor of MEK and, therefore, its downstream targets, ERK1/2, was employed (Dudley et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, the exact opposite were observed using BMP4; ERK1/2 inhibition prevented STAT3 serine phosphorylation, whereas mTOR obstruction did not."
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"STAT3 serine phosphorylation by ERK dependent and -independent pathways negatively modulates its tyrosine phosphorylation."
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"It is possible, therefore, that IL-2-induced STAT3 serine phosphorylation mediated by PI3K and ERK activation is necessary for optimal transactivation of cell cycle related genes, thereby promoting ce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Tyr phosphorylation of Erk and Ser phosphorylation of STAT-3 were inhibited by PD98059, while Tyr phosphorylation of STAT-3 was not inhibited by PD98059."
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"However, Erk independent serine phosphorylation of Stat3 has also been reported [18,19]."
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rlimsp
"Taken together, we found that WKYMVm stimulated FPRL1, and that this resulted in STAT3 serine phosphorylation via PLD-mediated ERK activation, and that the serine phosphorylation of STAT3 blocked hydrogen peroxide-induced STAT3 activity."
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"Finally, we determined that the inhibition of ERK prevented injury induced serine phosphorylation of STAT3 in an ex-vivo explants culture of the sciatic nerves."
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"To strengthen the finding that the serine phosphorylation of STAT3 was mediated by an ERK dependent pathway, two unrelated ERK inducing agents were tested for their ability to induce serine phosphoryl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, serine phosphorylation of STAT3 by ERK has been reported to negatively modulate STAT3 tyrosine phosphorylation and activity [XREF_BIBR, XREF_BIBR], while other studies implicate the MEK and ERK cascade in positively mediating STAT3 activity [XREF_BIBR - XREF_BIBR]."
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"These results suggest that JAK2 and ERK may mediate tyrosine and serine phosphorylation of STAT3 induced by histamine, respectively, and that both phosphorylations may be required for the activation o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, PDGF-BB-induced STAT3 tyrosine and serine phosphorylation in hBMMSCs are directly mediated by JAK2 and ERK1/2, respectively."
18583177
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"Erk is reportedly activated downstream of LMP1 and induces the serine phosphorylation of STAT3 [32]."
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"It is now obvious that serine phosphorylation of STAT-3 by ERKs, p38, or Jun-N-terminal kinase [36] is required for maximal transcriptional activation of STAT-3 [37,38], a situation which has also bee[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Serine phosphorylation of STAT-3 is mediated by ERK1/2, while tyrosine phosphorylation is mediated by Src."
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"Also, ROS from NADPH oxidase favors ERK1/2 activation that phosphorylates Stat3 in serine, resulting in a compensatory or adaptive survival response such as production of metallothionein-II in short Cd exposure times."
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"STAT3 serine phosphorylation is often mediated by ERK1/2 (Decker and Kovarik, 2000), although mTOR dependent phosphorylation has also been reported (Rajan et al., 2003)."
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"Inhibition of ERK1/2 by PD98059 prevented serine phosphorylation of STAT-3, whereas inhibition of Src by PP1 prevented STAT-3 tyrosine phosphorylation."
15833272
rlimsp
"Interestingly, serine phosphorylation of STAT3 by ERK has been reported to negatively modulate STAT3 tyrosine phosphorylation and activity [250, 251], while other studies implicate the MEK/ERK cascade in positively mediating STAT3 activity [252–254]."
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