IndraLab

Statements

KCNQ1 binds KCN. 8 / 9
| 8
sparser
"MinK is a potassium channel subunit which co-assembles with KvLQT1 to form the slowly activated, delayed rectifier K current that plays an important role in cardiac depolarization( xref ; xref )."
25442735
sparser
"The I Ks channel is constituted by four KCNQ1 proteins, which can form functional homomeric potassium channels, plus an uncertain (probably two) number of KCNE1 β -subunits ( 4,5 )."
19413992
sparser
"CALM1 is responsible for the mediation of L-type calcium channel depending on voltage [ xref ], regulation of CACNA1C inactivation depending on calcium [ xref ], positive regulation of KCNN2's potassium channel activity activated by calcium [ xref ], formation of the KCNQ1-based potassium channel complex, and regulation of channel electrophysiological activities by binding to calcium [ xref ]."
34899951
sparser
"The AKAP9 Yotiao domain [53] forms macromolecular complexes with the slowly activating cardiac potassium channel (I Ks ) formed by KCNQ1 [54] and mutation of AKAP9 has been reported in one individual [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20594883
sparser
"In a heterozygote, wild type and defective monomers can co-assemble to form an impaired KCNQ1 potassium channel complex, which can result in a prolonged QT interval ( xref ; xref )."
30461122
sparser
"Potassium channels formed by the KCNQ1 proteins are mainly located in the inner ear and in the cardiac muscles."
30500500
sparser
"We also observed drastic reductions in Kcne1 and Kcne2 expression, which is not surprising because KCNE1 and KCNE2 subunits form potassium channel complexes with KCNQ1 that are important for K + secretion and production of inner ear endolymph."
31550482
sparser
"KCNE1 encodes a regulatory subunit of the KCNQ1 potassium channel-complex."
35903368